The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC *W EXP 12/24/201 00289Y115 15,846 1,259,636 SH   SOLE   1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 1,993 116,900 SH   SOLE   116,900 0 0
ABIOMED INC COM 003654100 8,722 51,729 SH   SOLE   51,729 0 0
ACASTI PHARMA INC CL A NEW 00430K402 267 186,559 SH   SOLE   186,559 0 0
ACCELERON PHARMA INC COM 00434H108 60,319 1,616,259 SH   SOLE   1,616,259 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 5,725 1,244,608 SH   SOLE   1,244,608 0 0
ACHAOGEN INC COM 004449104 439 27,551 SH   SOLE   27,551 0 0
ADMA BIOLOGICS INC COM 000899104 2,221 721,102 SH   SOLE   721,102 0 0
AFFIMED N V COM N01045108 1,503 668,214 SH   SOLE   668,214 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 32,062 1,630,000 SH   SOLE   1,630,000 0 0
ALBIREO PHARMA INC COM 01345P106 17,703 845,000 SH   SOLE   845,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 22,215 3,085,458 SH   SOLE   3,085,458 0 0
ALIGN TECHNOLOGY INC COM 016255101 642 3,448 SH   SOLE   3,448 0 0
ALLIQUA BIOMEDICAL INC COM NEW 019621200 15,458 4,233,951 SH   SOLE   4,233,951 0 0
ALNYLAM PHARMACEUTICALS COM 02043Q107 210,167 1,788,802 SH   SOLE   1,788,802 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 2,315 100,000 SH Call SOLE   100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 45 420,000 SH Put SOLE   420,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 269,760 17,888,597 SH   SOLE   17,888,597 0 0
ANAPTYSBIO INC COM 032724106 34,330 982,269 SH   SOLE   982,269 0 0
ANI PHARMACEUTICALS NOTE 3.00% 12/0 00182CAA1 8,119 7,500,000 PRN   SOLE   7,500,000 0 0
ANTARES PHARMA INC COM 036642106 14,107 4,353,897 SH   SOLE   4,353,897 0 0
ARDELYX INC COM 039697107 7,573 1,352,391 SH   SOLE   1,352,391 0 0
ARGENX SE SPONSORED ADR 04016X101 10,098 450,000 SH   SOLE   450,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 15,429 441,833 SH   SOLE   441,833 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 581 35,106 SH   SOLE   35,106 0 0
ATHENAHEALTH SHARES COM 04685W103 8,705 70,000 SH   SOLE   70,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 21,885 781,309 SH   SOLE   781,309 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 16,265 1,549,005 SH   SOLE   1,549,005 0 0
AVEO PHARMACEUTICALS INC COM 053588109 12,555 3,415,116 SH   SOLE   3,415,116 0 0
AVEXIS INC COM 05366U100 64,923 671,181 SH   SOLE   671,181 0 0
AZURRX BIOPHARMA INC COM 05502L105 907 227,272 SH   SOLE   227,272 0 0
BEIGENE LTD SPONSORED ADR 07725L102 590 5,700 SH   SOLE   5,700 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 11,443 306,134 SH   SOLE   306,134 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 29,586 424,661 SH   SOLE   424,661 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,648 400,000 SH   SOLE   400,000 0 0
CAPITAL SR LIVING CORP COM 140475104 7,031 560,173 SH   SOLE   560,173 0 0
CENTENE CORP DEL COM 15135B101 748 7,726 SH   SOLE   7,726 0 0
CHAMPIONS ONCOLOGY INC COM 15870P307 1,418 386,540 SH   SOLE   386,540 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 5,147 620,181 SH   SOLE   620,181 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 6,291 352,250 SH   SOLE   352,250 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 2,964 414,684 SH   SOLE   414,684 0 0
CORIUM INTL INC COM 21887L107 64,786 5,847,133 SH   SOLE   5,847,133 0 0
CURIS INC COM 231269101 1,417 951,201 SH   SOLE   951,201 0 0
CUTERA INC COM 232109108 495 11,981 SH   SOLE   11,981 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 18,948 2,350,882 SH   SOLE   2,350,882 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 25,263 1,390,381 SH   SOLE   1,390,381 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 24,463 576,419 SH   SOLE   576,419 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 2,808 550,000 SH Put SOLE   550,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1,946 102,500 SH   SOLE   102,500 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 42,587 1,754,015 SH   SOLE   1,754,015 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,734 157,679 SH   SOLE   157,679 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 540 10,769 SH   SOLE   10,769 0 0
EVOLENT HEALTH INC CL A 30050B101 15,130 850,000 SH   SOLE   850,000 0 0
EXACT SCIENCES CORP COM 30063P105 6,382 135,444 SH   SOLE   135,444 0 0
EXELIXIS INC COM 30161Q104 1,123 46,361 SH   SOLE   46,361 0 0
FERRARI N V COM N3167Y103 685 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHRS N31738102 1,110 62,000 SH   SOLE   62,000 0 0
FIBROGEN INC COM 31572Q808 462 8,593 SH   SOLE   8,593 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 6,201 1,117,324 SH   SOLE   1,117,324 0 0
GALAPAGOS N V SPON ADR 36315X101 21,002 206,405 SH   SOLE   206,405 0 0
GILEAD SCIENCES INC COM 375558103 3,241 40,000 SH   SOLE   40,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 132,399 4,264,066 SH   SOLE   4,264,066 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 3,731 36,763 SH   SOLE   36,763 0 0
HERON THERAPEUTICS INC COM 427746102 5,329 330,000 SH   SOLE   330,000 0 0
HESKA CORP COM RESTRC NEW 42805E306 643 7,300 SH   SOLE   7,300 0 0
HISTOGENICS CORP COM 43358V109 3,519 1,777,777 SH   SOLE   1,777,777 0 0
HUMANA INC COM 444859102 24,363 100,000 SH   SOLE   100,000 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 273 10,000 SH   SOLE   10,000 0 0
IMMUNOGEN INC COM 45253H101 536 70,126 SH   SOLE   70,126 0 0
INCYTE CORP COM 45337C102 35 100,000 SH Call SOLE   100,000 0 0
INCYTE CORP COM 45337C102 656 5,619 SH   SOLE   5,619 0 0
INOVALON HLDGS INC COM CL A 45781D101 511 30,000 SH   SOLE   30,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 5,224 90,000 SH   SOLE   90,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 283 250,000 SH Call SOLE   250,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 14,667 929,460 SH   SOLE   929,460 0 0
INVACARE CORP COM 461203101 3,950 200,000 SH   SOLE   200,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 26,351 25,195 SH   SOLE   25,195 0 0
INVITAE CORP COM 46185L103 17,657 1,884,500 SH   SOLE   1,884,500 0 0
IONIS PHARMACEUTICALS INC COM 462222100 24 60,000 SH Call SOLE   60,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 36,627 4,726,114 SH   SOLE   4,726,114 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 19,335 372,671 SH   SOLE   372,671 0 0
KADMON HLDGS INC COM 48283N106 17,372 5,185,847 SH   SOLE   5,185,847 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 592 83,386 SH   SOLE   83,386 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR.0001 2 503459604 75,021 2,157,011 SH   SOLE   2,157,011 0 0
LANTHEUS HLDGS INC COM 516544103 957 53,763 SH   SOLE   53,763 0 0
MARINUS PHARMACEUTICALS COM 56854Q101 8,527 1,452,700 SH   SOLE   1,452,700 0 0
MERIT MEDICAL SYS INC COM 589889104 4,235 100,000 SH   SOLE   100,000 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,261 252,327 SH   SOLE   252,327 0 0
MOLECULAR TEMPLATES INC COM 608550109 4,231 724,133 SH   SOLE   724,133 0 0
MOLINA HEALTHCARE INC COM 60855R100 345 50,000 SH Call SOLE   50,000 0 0
MYOKARDIA INC COM 62857M105 23,598 550,717 SH   SOLE   550,717 0 0
NABRIVA THERAPEUTICS PLC SHS G63637105 431 52,570 SH   SOLE   52,570 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 4,113 6,519,634 SH   SOLE   6,519,634 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 293,629 4,791,589 SH   SOLE   4,791,589 0 0
NEWLINK GENETICS CORP COM 651511107 4,581 450,000 SH   SOLE   450,000 0 0
NUCANA PLS SPONSORED ADR 67022C106 3,674 200,000 SH   SOLE   200,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 34,901 1,264,523 SH   SOLE   1,264,523 0 0
OCERA THERAPEUTICS INC COM 67552A108 2,324 2,038,880 SH   SOLE   2,038,880 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 4,693 1,038,289 SH   SOLE   1,038,289 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 1,231 54,729 SH   SOLE   54,729 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 7,818 465,356 SH   SOLE   465,356 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 532 21,186 SH   SOLE   21,186 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 420 1,000,000 PRN   SOLE   1,000,000 0 0
PFENEX INC COM 717071104 2,555 845,973 SH   SOLE   845,973 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 425 7,870 SH   SOLE   7,870 0 0
PRA HEALTH SCIENCES INC COM 69354M108 566 7,427 SH   SOLE   7,427 0 0
PROTEON THERAPEUTICS INC COM 74371L109 668 334,116 SH   SOLE   334,116 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 110,627 923,820 SH   SOLE   923,820 0 0
QUOTIENT TECHNOLOGY INC COM G73268107 18,374 3,726,986 SH   SOLE   3,726,986 0 0
REGENXBIO INC COM 75901B107 47,487 1,441,186 SH   SOLE   1,441,186 0 0
REPLIGEN INC COM 759916109 3,349 87,400 SH   SOLE   87,400 0 0
RETROPHIN INC COM 761299106 66,859 2,686,204 SH   SOLE   2,686,204 0 0
SAGE THERAPEUTICS INC COM 78667J108 178 215,000 SH Call SOLE   215,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 21,212 1,162,325 SH   SOLE   1,162,325 0 0
SENSEONICS HOLDINGS INC COM 81727U105 160 50,000 SH   SOLE   50,000 0 0
SERES THERAPEUTICS INC COM 81750R102 2,165 135,000 SH   SOLE   135,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 5,666 3,655,186 SH   SOLE   3,655,186 0 0
SPARK THERAPEUTICS INC COM 84652J103 16,049 180,000 SH   SOLE   180,000 0 0
SYNLOGIC INC COM 87166L100 13,050 686,352 SH   SOLE   686,352 0 0
TELADOC INC COM 87918A105 485 14,641 SH   SOLE   14,641 0 0
TELEFLEX INC COM 879369106 13,357 55,200 SH   SOLE   55,200 0 0
TESARO INC COM 881569107 50,175 388,651 SH   SOLE   388,651 0 0
UNIQURE NV SHS N90064101 9,985 1,040,119 SH   SOLE   1,040,119 0 0
UROGEN PHARMA LTD COM M96088105 8,479 269,014 SH   SOLE   269,014 0 0
VANDA PHARMACEUTICALS INC COM 921659108 649 36,232 SH   SOLE   36,232 0 0
VBI VACCINES INC COM NEW 91822J103 25,278 6,565,843 SH   SOLE   6,565,843 0 0
VERONA PHARMA PLC SPONSORED ADR 925050106 3,070 200,000 SH   SOLE   200,000 0 0
VERSARTIS INC COM 92529L102 4,625 1,888,160 SH   SOLE   1,888,160 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 21,077 138,626 SH   SOLE   138,626 0 0
VIVEVE MEDICAL INC COM NEW 92852W204 2,551 486,988 SH   SOLE   486,988 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 712 34,604 SH   SOLE   34,604 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 13,980 642,798 SH   SOLE   642,798 0 0
XENCOR INC COM 98401F105 29,638 1,293,095 SH   SOLE   1,293,095 0 0
XENON PHARMACEUTICALS INC COM 9842ON105 1,486 503,853 SH   SOLE   503,853 0 0
ZAI LAB LTD ADR 98887Q104 4,725 175,000 SH   SOLE   175,000 0 0
ZOGENIX INC COM NEW 98978L204 128,646 3,670,357 SH   SOLE   3,670,357 0 0
ZOSANO PHARMA INC COM 98979H103 412 500,000 SH   SOLE   500,000 0 0
ZYMEWORKS INC COM 98985W102 5,832 730,768 SH   SOLE   730,768 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 1,320 130,700 SH   SOLE   130,700 0 0