The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 96,100 1,800,968 SH   DFND   0 1,800,968 0
ACCURAY INC COM 004397105 16,674 4,168,513 SH   DFND   0 4,168,513 0
ACORDA THERAPEUTICS INC COM 00484M106 95,837 4,052,289 SH   DFND   0 4,052,289 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 19,386 21,362,000 PRN   DFND   0 21,362,000 0
ACTIVISION BLIZZARD INC COM 00507V109 71,471 1,107,904 SH   DFND   0 1,107,904 0
AERIE PHARMACEUTICALS INC COM 00771V108 117,294 2,413,461 SH   DFND   0 2,413,461 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 62,925 364,341 SH   DFND   0 364,341 0
ALLERGAN PLC PFD CONV SER A G0177J116 79,249 107,410 SH   DFND   0 107,410 0
ALLERGAN PLC SHS G0177J108 88 428 SH   DFND   0 428 0
ALPHABET INC CAP STK CL A 02079K305 84,503 86,784 SH   DFND   0 86,784 0
AMAZON COM INC COM 023135106 90,686 94,332 SH   DFND   0 94,332 0
ANTHEM INC COM 036752103 120,065 632,321 SH   DFND   0 632,321 0
BAXTER INTL INC COM 071813109 103,077 1,642,668 SH   DFND   0 1,642,668 0
BLACKROCK INC COM 09247X101 20,267 45,330 SH   DFND   0 45,330 0
BLUEPRINT MEDICINES CORP COM 09627Y109 113,498 1,629,086 SH   DFND   0 1,629,086 0
BOX INC CL A 10316T104 55,955 2,896,214 SH   DFND   0 2,896,214 0
CARDIOVASCULAR SYS INC DEL COM 141619106 12,552 445,891 SH   DFND   0 445,891 0
CENTENE CORP DEL COM 15135B101 69,316 716,300 SH Call DFND   0 716,300 0
CENTENE CORP DEL COM 15135B101 85,576 884,325 SH   DFND   0 884,325 0
CIGNA CORPORATION COM 125509109 79,893 427,374 SH   DFND   0 427,374 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 5,695 337,201 SH   DFND   0 337,201 0
CLOVIS ONCOLOGY INC COM 189464100 18,168 220,487 SH   DFND   0 220,487 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 53,670 34,710,000 PRN   DFND   0 34,710,000 0
COUPA SOFTWARE INC COM 22266L106 60 1,937 SH   DFND   0 1,937 0
CUTERA INC COM 232109108 17,663 427,163 SH   DFND   0 427,163 0
DXC TECHNOLOGY CO COM 23355L106 40,223 468,360 SH   DFND   0 468,360 0
EDWARDS LIFESCIENCES CORP COM 28176E108 113,401 1,037,424 SH   DFND   0 1,037,424 0
ENDOLOGIX INC COM 29266S106 29,699 6,658,983 SH   DFND   0 6,658,983 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 35,156 40,409,000 PRN   DFND   0 40,409,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 27,500 548,682 SH   DFND   0 548,682 0
EVOLENT HEALTH INC CL A 30050B101 36,722 2,063,033 SH   DFND   0 2,063,033 0
FACEBOOK INC CL A 30303M102 38,394 224,700 SH Call DFND   0 224,700 0
FACEBOOK INC CL A 30303M102 100,520 588,286 SH   DFND   0 588,286 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 18,566 25,122,500 PRN   DFND   0 25,122,500 0
GODADDY INC CL A 380237107 108,022 2,482,695 SH   DFND   0 2,482,695 0
HILL ROM HLDGS INC COM 431475102 22,551 304,738 SH   DFND   0 304,738 0
HUMANA INC COM 444859102 49,016 201,190 SH   DFND   0 201,190 0
ICON PLC SHS G4705A100 32,250 283,195 SH   DFND   0 283,195 0
INCYTE CORP COM 45337C102 47,747 409,000 SH Put DFND   0 409,000 0
INOGEN INC COM 45780L104 22,925 241,057 SH   DFND   0 241,057 0
INTERSECT ENT INC COM 46071F103 23,935 768,366 SH   DFND   0 768,366 0
INVUITY INC COM NEW 46187J205 8,271 929,293 SH   DFND   0 929,293 0
ISHARES TR RUSSELL 2000 464287655 23,961 161,700 SH   DFND   0 161,700 0
JD COM INC SPON ADR CL A 47215P106 78,638 2,058,588 SH   DFND   0 2,058,588 0
JOUNCE THERAPEUTICS INC COM 481116101 26,922 1,727,997 SH   DFND   0 1,727,997 0
JUNO THERAPEUTICS INC COM 48205A109 65,074 1,450,607 SH   DFND   0 1,450,607 0
KITE PHARMA INC COM 49803L109 529 2,944 SH   DFND   0 2,944 0
KURA ONCOLOGY INC COM 50127T109 36,053 2,411,552 SH   DFND   0 2,411,552 0
LENDINGCLUB CORP COM 52603A109 9,939 1,631,945 SH   DFND   0 1,631,945 0
LENDINGTREE INC NEW COM 52603B107 21,263 86,982 SH   DFND   0 86,982 0
MEDICINES CO COM 584688105 55,597 1,501,003 SH   DFND   0 1,501,003 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 31,098 29,442,000 PRN   DFND   0 29,442,000 0
MERIT MED SYS INC COM 589889104 29,960 707,440 SH   DFND   0 707,440 0
MICROSOFT CORP COM 594918104 77,981 1,046,867 SH   DFND   0 1,046,867 0
MIMEDX GROUP INC COM 602496101 11,659 981,400 SH Put DFND   0 981,400 0
MOLINA HEALTHCARE INC COM 60855R100 33,713 490,300 SH Call DFND   0 490,300 0
MOLINA HEALTHCARE INC COM 60855R100 49,239 716,094 SH   DFND   0 716,094 0
MYOKARDIA INC COM 62857M105 69,286 1,616,954 SH   DFND   0 1,616,954 0
NETEASE INC SPONSORED ADR 64110W102 34,292 129,987 SH   DFND   0 129,987 0
NETFLIX INC COM 64110L106 49,133 270,929 SH   DFND   0 270,929 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 9,877 514,427 SH   DFND   0 514,427 0
NVIDIA CORP COM 67066G104 22,245 124,434 SH   DFND   0 124,434 0
PALO ALTO NETWORKS INC COM 697435105 38,547 267,499 SH   DFND   0 267,499 0
PAYPAL HLDGS INC COM 70450Y103 48,091 751,075 SH   DFND   0 751,075 0
PENUMBRA INC COM 70975L107 53,338 590,673 SH   DFND   0 590,673 0
PERKINELMER INC COM 714046109 46,504 674,267 SH   DFND   0 674,267 0
PFIZER INC COM 717081103 200,534 5,617,200 SH Call DFND   0 5,617,200 0
PFIZER INC COM 717081103 54,637 1,530,437 SH   DFND   0 1,530,437 0
PORTOLA PHARMACEUTICALS INC COM 737010108 274,372 5,078,146 SH   DFND   0 5,078,146 0
POWERSHARES QQQ TRUST COM 73935A104 229,520 1,578,000 SH Put DFND   0 1,578,000 0
POWERSHARES QQQ TRUST COM 73935A104 163,180 1,121,900 SH Put DFND   0 1,121,900 0
PRA HEALTH SCIENCES INC COM 69354M108 8,629 113,283 SH   DFND   0 113,283 0
PUMA BIOTECHNOLOGY INC COM 74587V107 164,007 1,369,579 SH   DFND   0 1,369,579 0
S&P GLOBAL INC COM 78409V104 34,931 223,475 SH   DFND   0 223,475 0
SALESFORCE COM INC COM 79466L302 89,269 955,567 SH   DFND   0 955,567 0
SERVICENOW INC COM 81762P102 61,961 527,190 SH   DFND   0 527,190 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 35,164 1,580,410 SH   DFND   0 1,580,410 0
SKYWORKS SOLUTIONS INC COM 83088M102 20,526 201,435 SH   DFND   0 201,435 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 58,147 231,451 SH   DFND   0 231,451 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 184,126 2,126,900 SH Call DFND   0 2,126,900 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 39,920 461,125 SH   DFND   0 461,125 0
SQUARE INC CL A 852234103 20,401 708,119 SH   DFND   0 708,119 0
UNITEDHEALTH GROUP INC COM 91324P102 59,748 305,072 SH   DFND   0 305,072 0
VANECK VECTORS ETF TR GOLD MINERS 92189F106 82,056 879,300 SH Put DFND   0 879,300 0
VISA INC COM CL A 92826C839 20,011 190,147 SH   DFND   0 190,147 0
VOYAGER THERAPEUTICS INC COM 92915B106 8,193 397,923 SH   DFND   0 397,923 0
VULCAN MATLS CO COM 929160109 14,202 118,745 SH   DFND   0 118,745 0
ZAYO GROUP HLDGS INC COM 98919V105 69,453 2,017,797 SH   DFND   0 2,017,797 0
ZENDESK INC COM 98936J101 28,581 981,832 SH   DFND   0 981,832 0