The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADURO BIOTECH INC | COM | 00739L101 | 1,968 | 184,764 | SH | DFND | 1 | 0 | 184,764 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 7,839 | 675,759 | SH | DFND | 1 | 0 | 675,759 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 48,201 | 1,379,134 | SH | DFND | 1 | 0 | 1,379,134 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U300 | 1,449 | 1,006,507 | SH | DFND | 1 | 0 | 1,006,507 | 0 | |
| ARQULE INC | COM | 04269E107 | 8,214 | 7,400,128 | SH | DFND | 1 | 0 | 7,400,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 78,751 | 6,402,525 | SH | DFND | 1 | 0 | 6,402,525 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 29,115 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 70,182 | 1,007,354 | SH | DFND | 1 | 0 | 1,007,354 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM NEW | 14740B606 | 12,815 | 3,133,224 | SH | DFND | 1 | 0 | 3,133,224 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 56,299 | 7,587,416 | SH | DFND | 1 | 0 | 7,587,416 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 46,246 | 3,135,289 | SH | DFND | 1 | 0 | 3,135,289 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 3,885 | 3,500,000 | SH | DFND | 1 | 0 | 3,500,000 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 7,323 | 459,396 | SH | DFND | 1 | 0 | 459,396 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 27,422 | 8,596,357 | SH | DFND | 1 | 0 | 8,596,357 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 17,995 | 1,241,021 | SH | DFND | 1 | 0 | 1,241,021 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 40,535 | 2,230,898 | SH | DFND | 1 | 0 | 2,230,898 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 8,571 | 1,455,117 | SH | DFND | 1 | 0 | 1,455,117 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 45,186 | 3,229,856 | SH | DFND | 1 | 0 | 3,229,856 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 9,111 | 1,108,433 | SH | DFND | 1 | 0 | 1,108,433 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 10,462 | 7,866,108 | SH | DFND | 1 | 0 | 7,866,108 | 0 | |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 14,991 | 950,000 | SH | DFND | 1 | 0 | 950,000 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 44,471 | 2,820,000 | SH | DFND | 1 | 0 | 2,820,000 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 20,240 | 1,353,846 | SH | DFND | 1 | 0 | 1,353,846 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 21,960 | 238,386 | SH | DFND | 1 | 0 | 238,386 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 5,047 | 724,132 | SH | DFND | 1 | 0 | 724,132 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 19,889 | 4,400,289 | PRN | DFND | 1 | 0 | 4,400,289 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 1,558 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 4,769 | 10,000,000 | SH | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM NEW | 69562K506 | 1,325 | 325,508 | SH | DFND | 1 | 0 | 325,508 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 17,203 | 2,986,562 | SH | DFND | 1 | 0 | 2,986,562 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 16,187 | 12,949,229 | SH | DFND | 1 | 0 | 12,949,229 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 10,991 | 652,676 | SH | DFND | 1 | 0 | 652,676 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 3,964 | 2,043,196 | SH | DFND | 1 | 0 | 2,043,196 | 0 | |
| TOCAGEN INC | COM | 888846102 | 13,245 | 1,063,028 | SH | DFND | 1 | 0 | 1,063,028 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 10,587 | 3,588,830 | SH | DFND | 1 | 0 | 3,588,830 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 29,530 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |
| ZEALAND PHARMA A S | SPONSORED ADR | 98920Y304 | 19,200 | 1,000,000 | SH | DFND | 1 | 0 | 1,000,000 | 0 | |