The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58 COM INC SPON ADR REP A 31680Q104 12,628 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
AC IMMUNE SA SHS H00263105 5,585 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 4,490 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ACCELERON PHARMA INC COM 00434H108 26,124 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
ACHAOGEN INC COM 004449104 3,988 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 4,490 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONSORED ADR 00653A107 4,095 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ADURO BIOTECH INC COM 00739L101 2,130 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AGENUS INC COM NEW 00847G705 11,025 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 30,038 450,000 SH   DFND 1,2,3,4,5 450,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 6,125 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ALLERGAN PLC SHS G0177J108 40,990 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 29,373 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 23,745 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AMGEN INC COM 031162100 18,645 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 10,556 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 15,080 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
ANAPTYSBIO INC COM 032724106 5,243 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ARGENX SE SPONSORED ADR 04016X101 1,229 54,337 SH   DFND 1,2,3,4,5 54,337 0 0
ARRAY BIOPHARMA INC COM 04269X105 18,450 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 12,300 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 9,930 600,000 SH   DFND 1,2,3,4,5 600,000 0 0
ATYR PHARMA INC COM 002120103 1,263 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 5,602 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AVEXIS INC COM 05366U100 11,608 120,000 SH   DFND 1,2,3,4,5 120,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 3,440 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
BANK AMER CORP COM 060505104 249,599 9,850,000 SH Call DFND 1,2,3,4,5 9,850,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 23,279 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 2,310 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 3,406 650,000 SH   DFND 1,2,3,4,5 650,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,869 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,614 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 9,307 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BIOTIME INC COM 09066L105 3,641 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLACKROCK INC COM 09247X101 22,355 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUEBIRD BIO INC COM 09609G100 18,542 135,000 SH   DFND 1,2,3,4,5 135,000 0 0
BLUEBIRD BIO INC COM 09609G100 6,868 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 2,479,516 87,460,875 SH   DFND 1,2,3,4 87,460,875 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 41,431 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 2,756 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 1,931 675,000 SH   DFND 1,2,3,4,5 675,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 2,845 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CHEMOCENTRYX INC COM 16383L106 3,710 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CHIMERIX INC COM 16934W106 2,625 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CITIGROUP INC COM NEW 172967424 21,822 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 9,476 115,000 SH   DFND 1,2,3,4,5 115,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,073 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 1,407 234,493 SH   DFND 1,2,3,4,5 234,493 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,225 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
E L F BEAUTY INC COM 26856L103 4,510 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
FIBROGEN INC COM 31572Q808 2,690 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,046 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
GILEAD SCIENCES INC COM 375558103 20,255 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 9,315 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 7,763 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
GLYCOMIMETICS INC COM 38000Q102 2,833 202,500 SH   DFND 1,2,3,4,5 202,500 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 47,438 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
HORIZON PHARMA PLC SHS G4617B105 6,340 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
HORIZON PHARMA PLC SHS G4617B105 6,340 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
IGNYTA INC COM 451731103 11,115 900,000 SH   DFND 1,2,3,4,5 900,000 0 0
INCYTE CORP COM 45337C102 46,696 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
INCYTE CORP COM 45337C102 17,511 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
INTEL CORP COM 458140100 19,040 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 4,349 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 29,016 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 9,462 600,000 SH   DFND 1,2,3,4,5 600,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,420 216,879 SH   DFND 1,2,3,4 216,879 0 0
JOUNCE THERAPEUTICS INC COM 481116101 3,116 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 6,729 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 8,972 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
KRYSTAL BIOTECH INC COM 501147102 997 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,495 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 9,750 793,327 SH   DFND 1,2,3,4,5 793,327 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 697,146 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MACROGENICS INC COM 556099109 3,696 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MEDICINES CO COM 584688105 11,112 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
MEDICINES CO COM 584688105 7,408 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
METLIFE INC COM 59156R108 20,780 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,910 251,300 SH   DFND 1,2,3,4,5 251,300 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 915 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MORGAN STANLEY COM NEW 617446448 14,451 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
NANTKWEST INC COM 63016Q102 1,233 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
NEKTAR THERAPEUTICS COM 640268108 30,000 1,250,000 SH   DFND 1,2,3,4,5 1,250,000 0 0
NEKTAR THERAPEUTICS COM 640268108 14,400 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 24,512 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
NEWLINK GENETICS CORP COM 651511107 1,527 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
NEWLINK GENETICS CORP COM 651511107 2,036 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
NOVAVAX INC COM 670002104 570 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 1,802 256,400 SH   DFND 1,2,3,4,5 256,400 0 0
ONCOCYTE CORPORATION COM 68235C107 1,133 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 7,275 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 9,638 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
RADIUS HEALTH INC COM NEW 750469207 13,493 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
REGENXBIO INC COM 75901B107 5,272 160,000 SH   DFND 1,2,3,4,5 160,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,345 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 9,072 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SEATTLE GENETICS INC COM 812578102 5,441 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SERES THERAPEUTICS INC COM 81750R102 8,822 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,775 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,789 152,920 SH   DFND 1,2,3,4,5 152,920 0 0
TERADYNE INC COM 880770102 13,052 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
TESARO INC COM 881569107 9,683 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
TESARO INC COM 881569107 3,228 25,000 SH Call DFND 1,2,3,4,5 25,000 0 0
TG THERAPEUTICS INC COM 88322Q108 4,740 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,663 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
VERASTEM INC COM 92337C104 3,525 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
VERSARTIS INC COM 92529L102 980 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
VITAL THERAPIES INC COM 92847R104 4,419 875,000 SH   DFND 1,2,3,4,5 875,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 1,282,256 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
WELLS FARGO CO NEW COM 949746101 35,848 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
XENCOR INC COM 98401F105 2,292 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 443 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ZAFGEN INC COM 98885E103 3,520 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0