The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories COM 002824100 8,271 155,000 SH   SOLE   0 0 155,000
AbbVie Inc COM 00287Y109 12,440 140,000 SH   SOLE   0 0 140,000
Abiomed Inc COM 003654100 23,644 140,238 SH   SOLE   0 0 140,238
Achillion Pharmaceuticals Inc COM 00448Q201 3,817 850,000 SH   SOLE   0 0 850,000
Adamas Pharmaceuticals Inc COM 00548A106 19,371 915,000 SH   SOLE   0 0 915,000
Adverum Biotechnologies Inc COM 00773U108 562 154,006 SH   SOLE   0 0 154,006
Aerie Pharmaceuticals Inc COM 00771V108 5,877 120,932 SH   SOLE   0 0 120,932
Aetna Inc COM 00817Y108 9,859 62,000 SH   SOLE   0 0 62,000
Agios Pharmaceuticals Inc COM 00847X104 1,001 15,000 SH   SOLE   0 0 15,000
Alexion Pharmaceuticals Inc COM 015351109 23,148 165,000 SH   SOLE   0 0 165,000
Alkermes Plc SHS G01767105 7,372 145,000 SH   SOLE   0 0 145,000
Allergan Plc COM G0177J108 20,495 100,000 SH   SOLE   0 0 100,000
Alnylam Pharmaceuticals Inc SHS 02043Q107 5,028 42,793 SH   SOLE   0 0 42,793
AmerisourceBergen Corp COM 03073E105 6,620 80,000 SH   SOLE   0 0 80,000
Anheuser-Busch InBev SA ADR spons repr 1 Share ADR 03524A108 335 2,806 SH   SOLE   0 0 4,750
Anthem Inc COM 036752103 10,443 55,000 SH   SOLE   0 0 55,000
Arena Pharmaceuticals Inc Reg COM 040047607 14,522 569,491 SH   SOLE   0 0 569,491
Array BioPharma Inc COM 04269X105 7,995 650,000 SH   SOLE   0 0 650,000
Biogen Inc COM 09062X103 6,889 22,000 SH   SOLE   0 0 22,000
BioMarin Pharmaceutical Inc COM 09061G101 16,748 179,949 SH   SOLE   0 0 179,949
Bioverativ Inc Reg S COM 09075E100 1,997 35,000 SH   SOLE   0 0 35,000
Boston Scientific Corp COM 101137107 8,181 280,468 SH   SOLE   0 0 280,468
Bristol Myers Squibb Co COM 110122108 10,230 160,502 SH   SOLE   0 0 160,502
Celgene Corp COM 151020104 22,165 152,000 SH   SOLE   0 0 152,000
Centene Corp COM 15135B101 10,645 110,000 SH   SOLE   0 0 110,000
Chimerix Inc COM 16934W106 2,100 400,000 SH   SOLE   0 0 400,000
Cigna Corp COM 125509109 10,282 55,000 SH   SOLE   0 0 55,000
Coherus BioSciences Inc COM 19249H103 2,403 180,000 SH   SOLE   0 0 180,000
CVS Health Corp COM 126650100 9,758 120,000 SH   SOLE   0 0 120,000
Dermira Inc Reg COM 24983L104 2,700 100,000 SH   SOLE   0 0 100,000
Dexcom Inc COM 252131107 5,871 120,000 SH   SOLE   0 0 120,000
Dynavax Technologies Corp COM 268158201 8,053 374,537 SH   SOLE   0 0 374,537
Edwards Lifesciences Corp COM 28176E108 8,745 80,000 SH   SOLE   0 0 80,000
Eli Lilly & Co COM 532457108 9,409 110,000 SH   SOLE   0 0 110,000
Endologix Inc COM 29266S106 6,657 1,492,600 SH   SOLE   0 0 1,492,600
Epizyme Inc COM 29428V104 4,501 236,293 SH   SOLE   0 0 236,293
Esperion Therapeutics Inc COM 29664W105 15,628 311,803 SH   SOLE   0 0 311,803
Exelixis Inc COM 30161Q104 25,442 1,050,000 SH   SOLE   0 0 1,050,000
Express Scripts Hg Co COM 30219G108 15,513 245,000 SH   SOLE   0 0 245,000
Exxon Mobil Corp COM 30231G102 467 5,696 SH   SOLE   0 0 5,696
FibroGen Inc COM 31572Q808 7,828 145,500 SH   SOLE   0 0 145,500
Ford Motor Co COM 345370860 340 28,404 SH   SOLE   0 0 28,404
Gilead Sciences Inc COM 375558103 12,603 155,551 SH   SOLE   0 0 155,551
Glaukos Corp COM 377322102 21,377 647,796 SH   SOLE   0 0 647,796
Halliburton Co (Hg Co) COM 406216101 513 11,144 SH   SOLE   0 0 11,144
HCA Healthcare Inc COM 40412C101 3,980 50,000 SH   SOLE   0 0 50,000
Horizon Pharma Plc SHS G4617B105 38,127 3,006,862 SH   SOLE   0 0 3,006,862
Humana Inc COM 444859102 9,989 41,000 SH   SOLE   0 0 41,000
IBM Corp COM 459200101 256 1,766 SH   SOLE   0 0 1,766
Immunomedics Inc COM 452907108 6,990 500,000 SH   SOLE   0 0 500,000
Incyte Corp Ltd COM 45337C102 13,425 115,000 SH   SOLE   0 0 115,000
Intercept Pharmaceuticals Inc COM 45845P108 2,322 40,000 SH   SOLE   0 0 40,000
Intra-Cellular Therapies Inc COM 46116X101 18,619 1,179,900 SH   SOLE   0 0 1,179,900
Iovance Biotherapeutics Inc Reg COM 462260100 5,512 711,163 SH   SOLE   0 0 711,163
Janus Henderson Group Plc Reg NOTE 47102XAH8 472 13,556 SH   SOLE   0 0 13,556
Jazz Pharmaceuticals Plc SHS G50871105 12,431 85,000 SH   SOLE   0 0 85,000
JPMorgan Chase & Co COM 46625H100 539 5,641 SH   SOLE   0 0 5,641
Juno Therapeutics Inc COM 48205A109 4,486 100,000 SH   SOLE   0 0 100,000
Keryx Biopharmaceuticals Inc COM 492515101 2,840 400,000 SH   SOLE   0 0 400,000
Livanova Plc SHS G5509L101 6,656 95,000 SH   SOLE   0 0 95,000
Loxo Oncology Inc COM 548862101 6,909 75,000 SH   SOLE   0 0 75,000
Macrogenics Inc COM 556099109 4,101 221,914 SH   SOLE   0 0 221,914
Medtronic Plc SHS G5960L103 16,652 214,115 SH   SOLE   0 0 214,115
Merck & Co Inc COM 58933Y105 5,763 90,000 SH   SOLE   0 0 90,000
Microsoft Corp COM 594918104 357 4,793 SH   SOLE   0 0 4,793
MyoKardia Inc Reg COM 62857M105 6,465 150,872 SH   SOLE   0 0 150,872
Nektar Therapeutics COM 640268108 20,789 866,194 SH   SOLE   0 0 866,194
Neurocrine Biosciences Inc COM 64125C109 7,047 115,000 SH   SOLE   0 0 115,000
NewLink Genetics Corp COM 651511107 1,018 100,000 SH   SOLE   0 0 100,000
Nevro Corp COM 64157F103 11,814 130,000 SH   SOLE   0 0 130,000
Novo Nordisk AS ADR Repr 1 Share B ADR 670100205 3,852 80,000 SH   SOLE   0 0 80,000
NovoCure Ltd Reg SHS G6674U108 13,231 666,528 SH   SOLE   0 0 666,528
Omnicell Inc COM 68213N109 4,084 80,000 SH   SOLE   0 0 80,000
Pfizer Inc COM 717081103 372 10,422 SH   SOLE   0 0 10,422
Portola Pharmaceuticals Inc COM 737010108 16,069 297,400 SH   SOLE   0 0 297,400
Qualcomm Inc COM 747525103 278 5,368 SH   SOLE   0 0 5,368
Ra Pharmaceuticals Inc Reg COM 74933V108 1,748 119,697 SH   SOLE   0 0 119,697
Radius Health Inc COM 750469207 3,470 90,000 SH   SOLE   0 0 90,000
Regeneron Pharmaceuticals Inc COM 75886F107 9,837 22,000 SH   SOLE   0 0 22,000
Regulus Therapeutic Inc COM 75915K101 725 580,000 SH   SOLE   0 0 580,000
Revance Therapeutics Inc COM 761330109 6,788 246,400 SH   SOLE   0 0 246,400
Rigel Pharmaceuticals Inc COM 766559603 5,969 2,350,000 SH   SOLE   0 0 2,350,000
Rite Aid Corp COM 767754104 3,996 2,039,000 SH   SOLE   0 0 2,039,000
Sage Therapeutics Inc COM 78667J108 3,115 50,000 SH   SOLE   0 0 50,000
Sanofi spons ADR repr 0.5 Share ADR 80105N105 6,473 130,000 SH   SOLE   0 0 130,000
Staar Surgical Co COM 852312305 1,121 90,000 SH   SOLE   0 0 90,000
Symantec Corp COM 871503108 307 9,359 SH   SOLE   0 0 9,359
Ultragenyx Pharmaceutical Inc COM 90400D108 5,326 100,000 SH   SOLE   0 0 100,000
United Health Group Inc COM 91324P102 16,647 85,000 SH   SOLE   0 0 85,000
Universal Health Services Inc B CL B 913903100 5,547 50,000 SH   SOLE   0 0 5,000
Walgreens Boots Alliance Inc COM 931427108 5,405 70,000 SH   SOLE   0 0 70,000
Wells Fargo & Co COM 949746101 477 8,653 SH   SOLE   0 0 8,653
Vertex Pharmaceuticals Inc COM 92532F100 27,367 180,000 SH   SOLE   0 0 180,000
Xencor Inc COM 98401F105 5,730 250,000 SH   SOLE   0 0 250,000