The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58 COM INC SPON ADR REP A 31680Q104 195,285 4,427,241 SH   SOLE 4,202,741 0 224,500
ACADIA PHARMACEUTICALS INC COM 004225108 900 32,300 SH   SOLE 32,300 0 0
ACCELERON PHARMA INC COM 00434H108 2,096 69,000 SH   SOLE 69,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,233 42,500 SH   SOLE 42,500 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,841 35,800 SH   SOLE 35,800 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 285,405 2,025,592 SH   SOLE 1,876,392 0 149,200
ALPHABET INC CAP STK CL A 02079K305 169,017 181,802 SH   SOLE 164,912 0 16,890
ALPHABET INC CAP STK CL C 02079K107 198,512 218,451 SH   SOLE 196,465 0 21,986
AMEC FOSTER WHEELER PLC SPONSORED ADR 00167X205 180 29,908 SH   SOLE 29,908 0 0
APPLE INC COM 037833100 3,413 23,700 SH   SOLE 23,700 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 317 7,000 SH   SOLE 7,000 0 0
BAIDU INC SPON ADR REP A 056752108 282,437 1,579,100 SH   SOLE 1,423,345 0 155,755
BARRICK GOLD CORP COM 067901108 9,332 586,595 SH   SOLE 586,595 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,255 13,820 SH   SOLE 13,820 0 0
BITAUTO HLDGS LTD SPONSORED ADS 091727107 68,411 2,379,526 SH   SOLE 2,379,526 0 0
CALLAWAY GOLF CO COM 131193104 26,289 2,057,100 SH   SOLE 2,057,100 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 38,871 592,831 SH   SOLE 442,011 0 150,820
CISCO SYS INC COM 17275R102 48,945 1,563,750 SH   SOLE 1,155,942 0 407,808
COCA COLA CO COM 191216100 118,526 2,642,733 SH   SOLE 2,484,733 0 158,000
CONFORMIS INC COM 20717E101 1,437 335,156 SH   SOLE 335,156 0 0
DERMIRA INC COM 24983L104 1,681 57,700 SH   SOLE 57,700 0 0
EBAY INC COM 278642103 52,608 1,506,535 SH   SOLE 1,065,344 0 441,191
FACEBOOK INC CL A 30303M102 292 1,940 SH   SOLE 1,940 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 17,229 175,200 SH   SOLE 175,200 0 0
FOUNDATION MEDICINE INC COM 350465100 3,605 90,700 SH   SOLE 90,700 0 0
GILDAN ACTIVEWEAR INC COM 375916103 14,529 472,800 SH   SOLE 472,800 0 0
GILEAD SCIENCES INC COM 375558103 204,520 2,889,530 SH   SOLE 2,517,430 0 372,100
GROUPON INC COM 399473107 1,562 407,000 SH   SOLE 407,000 0 0
HANESBRANDS INC COM 410345102 43,184 1,864,600 SH   SOLE 1,575,300 0 289,300
HOLLYFRONTIER CORP COM 436106108 27,294 993,600 SH   SOLE 776,200 0 217,400
ICON PLC SHS G4705A100 2,298 23,500 SH   SOLE 23,500 0 0
IHS MARKIT LTD SHS G47567105 22,262 505,500 SH   SOLE 505,500 0 0
INCYTE CORP COM 45337C102 1,695 13,464 SH   SOLE 13,464 0 0
INFINERA CORPORATION COM 45667G103 3,518 329,800 SH   SOLE 329,800 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,272 810,232 SH   SOLE 810,232 0 0
INTEL CORP COM 458140100 110,078 3,262,551 SH   SOLE 2,920,351 0 342,200
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,972 104,500 SH   SOLE 104,500 0 0
JD COM INC SPON ADR CL A 47215P106 50,939 1,298,822 SH   SOLE 1,298,822 0 0
JOHNSON & JOHNSON COM 478160104 47,138 356,327 SH   SOLE 356,327 0 0
JONES LANG LASALLE INC COM 48020Q107 79,326 634,613 SH   SOLE 582,013 0 52,600
LAM RESEARCH CORP COM 512807108 311 2,200 SH   SOLE 2,200 0 0
LEVEL 3 COMMUNICATIONS INC COM NEW 52729N308 17,108 288,500 SH   SOLE 288,500 0 0
LIVANOVA PLC SHS G5509L101 2,067 33,782 SH   SOLE 33,782 0 0
MERCK & CO INC COM 58933Y105 1,204 18,800 SH   SOLE 18,800 0 0
MERUS N V COM N5749R100 1,620 102,219 SH   SOLE 102,219 0 0
MICRON TECHNOLOGY INC COM 595112103 716 24,000 SH   SOLE 24,000 0 0
MICROSOFT CORP COM 594918104 1,599 23,200 SH   SOLE 23,200 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 1,521 92,000 SH   SOLE 92,000 0 0
NEWMONT MINING CORP COM 651639106 3,271 101,000 SH   SOLE 101,000 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 98,004 2,535,040 SH   SOLE 2,186,525 0 348,515
NXP SEMICONDUCTORS N V COM N6596X109 1,039 9,500 SH   SOLE 9,500 0 0
ORACLE CORP COM 68389X105 287,297 5,729,900 SH   SOLE 5,105,872 0 624,028
PAYPAL HLDGS INC COM 70450Y103 163,605 3,048,368 SH   SOLE 2,655,368 0 393,000
PERKINELMER INC COM 714046109 2,930 43,000 SH   SOLE 43,000 0 0
PFIZER INC COM 717081103 1,599 47,610 SH   SOLE 47,610 0 0
PROTHENA CORP PLC SHS G72800108 3,598 66,500 SH   SOLE 66,500 0 0
QIAGEN NV SHS NEW N72482123 37,973 1,132,511 SH   SOLE 1,132,511 0 0
QIWI PLC SPON ADR REP B 74735M108 35,616 1,443,139 SH   SOLE 1,107,599 0 335,540
QUALCOMM INC COM 747525103 331 6,000 SH   SOLE 6,000 0 0
SCHLUMBERGER LTD COM 806857108 65,227 990,700 SH   SOLE 790,400 0 200,300
SEATTLE GENETICS INC COM 812578102 1,655 32,000 SH   SOLE 32,000 0 0
SINA CORP ORD G81477104 284,488 3,348,101 SH   SOLE 3,221,614 0 126,487
SKYWORKS SOLUTIONS INC COM 83088M102 106,078 1,105,560 SH   SOLE 981,260 0 124,300
TECHNIPFMC PLC COM G87110105 190,837 7,016,100 SH   SOLE 6,229,900 0 786,200
TIFFANY & CO NEW COM 886547108 13,282 141,500 SH   SOLE 141,500 0 0
TIME WARNER INC COM NEW 887317303 745 7,421 SH   SOLE 7,421 0 0
TWITTER INC PUT 90184l952 30 2,900 SH Put SOLE 2,900 0 0
UNITED TECHNOLOGIES CORP COM 913017109 976 8,000 SH   SOLE 8,000 0 0
VERISIGN INC COM 92343E102 520 5,600 SH   SOLE 5,600 0 0
WEIBO CORP SPONSORED ADR 948596101 27,010 406,353 SH   SOLE 393,705 0 12,648
WYNN RESORTS LTD COM 983134107 183,050 1,364,830 SH   SOLE 1,232,411 0 132,419
XILINX INC COM 983919101 720 11,200 SH   SOLE 11,200 0 0
YANDEX N V SHS CLASS A N97284108 4,237 161,500 SH   SOLE 161,500 0 0