The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 16,019 | 3,490,077 | SH | DFND | 1 | 0 | 3,490,077 | 0 | |
| ADURO BIOTECH INC | COM | 00739L101 | 3,420 | 300,000 | SH | DFND | 1 | 0 | 300,000 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 39,705 | 1,659,200 | SH | DFND | 1 | 0 | 1,659,200 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U300 | 1,631 | 1,006,507 | SH | DFND | 1 | 0 | 1,006,507 | 0 | |
| ARQULE INC | COM | 04269E107 | 9,176 | 7,400,128 | SH | DFND | 1 | 0 | 7,400,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 50,719 | 6,059,625 | SH | DFND | 1 | 0 | 6,059,625 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 14,875 | 17,500,000 | SH | DFND | 1 | 0 | 17,500,000 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 80,649 | 1,591,646 | SH | DFND | 1 | 0 | 1,591,646 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM NEW | 14740B606 | 11,640 | 3,133,224 | SH | DFND | 1 | 0 | 3,133,224 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 77,205 | 8,248,416 | SH | DFND | 1 | 0 | 8,248,416 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 25,904 | 1,856,895 | SH | DFND | 1 | 0 | 1,856,895 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 3,318 | 274,196 | SH | DFND | 1 | 0 | 274,196 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 28,454 | 8,596,357 | SH | DFND | 1 | 0 | 8,596,357 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 24,083 | 1,990,321 | SH | DFND | 1 | 0 | 1,990,321 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 31,418 | 2,026,998 | SH | DFND | 1 | 0 | 2,026,998 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 1,268 | 391,386 | SH | DFND | 1 | 0 | 391,386 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 28,215 | 1,387,853 | SH | DFND | 1 | 0 | 1,387,853 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 33,147 | 2,970,182 | SH | DFND | 1 | 0 | 2,970,182 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 5,864 | 1,108,433 | SH | DFND | 1 | 0 | 1,108,433 | 0 | |
| IGNYTA INC | COM | 451731103 | 7,245 | 700,000 | SH | DFND | 1 | 0 | 700,000 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 12,350 | 7,866,108 | SH | DFND | 1 | 0 | 7,866,108 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 37,159 | 463,386 | SH | DFND | 1 | 0 | 463,386 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 6,374 | 2,644,806 | SH | DFND | 1 | 0 | 2,644,806 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 14,653 | 4,400,289 | SH | DFND | 1 | 0 | 4,400,289 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 2,131 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750% | 686164AB0 | 5,025 | 10,000,000 | PRN | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM NEW | 69562K506 | 1,341 | 325,508 | SH | DFND | 1 | 0 | 325,508 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 17,669 | 3,491,933 | SH | DFND | 1 | 0 | 3,491,933 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 3,232 | 3,278,900 | SH | DFND | 1 | 0 | 3,278,900 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 8,332 | 615,384 | SH | DFND | 1 | 0 | 615,384 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 4,781 | 1,770,692 | SH | DFND | 1 | 0 | 1,770,692 | 0 | |
| TOCAGEN INC | COM | 888846102 | 15,387 | 1,279,078 | SH | DFND | 1 | 0 | 1,279,078 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 11,084 | 3,518,830 | SH | DFND | 1 | 0 | 3,518,830 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 10,505 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |