The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 53,606 1,102,781 SH   DFND   0 1,102,781 0
ACCURAY INC COM 004397105 22,878 4,816,334 SH   DFND   0 4,816,334 0
ACORDA THERAPEUTICS INC COM 00484M106 50,987 2,588,157 SH   DFND   0 2,588,157 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 10,685 12,380,000 PRN   DFND   0 12,380,000 0
ACTIVISION BLIZZARD INC COM 00507V109 28,427 493,776 SH   DFND   0 493,776 0
AERIE PHARMACEUTICALS INC COM 00771V108 91,860 1,748,040 SH   DFND   0 1,748,040 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 9,551 834,191 SH   DFND   0 834,191 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 99,059 703,046 SH   DFND   0 703,046 0
ALPHABET INC CAP STK CL A 02079K305 38,468 41,378 SH   DFND   0 41,378 0
AMAZON COM INC COM 023135106 58,479 60,412 SH   DFND   0 60,412 0
AMERICAN TOWER CORP NEW COM 03027X100 30,215 228,350 SH   DFND   0 228,350 0
ANTHEM INC COM 036752103 104,472 555,316 SH   DFND   0 555,316 0
APPLE INC COM 037833100 19,271 133,808 SH   DFND   0 133,808 0
BAXTER INTL INC COM 071813109 71,472 1,180,582 SH   DFND   0 1,180,582 0
BIOGEN INC COM 09062X103 1,098 4,046 SH   DFND   0 4,046 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,897 153,018 SH   DFND   0 153,018 0
BLACKROCK INC COM 09247X101 19,406 45,942 SH   DFND   0 45,942 0
BLUEPRINT MEDICINES CORP COM 09627Y109 65,184 1,286,450 SH   DFND   0 1,286,450 0
BOX INC CL A 10316T104 22,871 1,253,879 SH   DFND   0 1,253,879 0
CARDIOVASCULAR SYS INC DEL COM 141619106 10,997 341,216 SH   DFND   0 341,216 0
CIGNA CORPORATION COM 125509109 60,971 364,245 SH   DFND   0 364,245 0
CLOVIS ONCOLOGY INC COM 189464100 34,656 370,141 SH   DFND   0 370,141 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 79,428 46,790,999 PRN   DFND   0 46,790,999 0
COHERUS BIOSCIENCES INC COM 19249H103 895 62,400 SH Call DFND   0 62,400 0
COHERUS BIOSCIENCES INC COM 19249H103 25,867 1,802,611 SH   DFND   0 1,802,611 0
CORNERSTONE ONDEMAND INC COM 21925Y103 3,739 104,588 SH   DFND   0 104,588 0
CORNERSTONE ONDEMAND INC NOTE 1.500% 7/0 21925YAB9 22,836 22,666,000 PRN   DFND   0 22,666,000 0
DXC TECHNOLOGY CO COM 23355L106 59,986 781,879 SH   DFND   0 781,879 0
EDWARDS LIFESCIENCES CORP COM 28176E108 72,695 614,811 SH   DFND   0 614,811 0
ENDOLOGIX INC COM 29266S106 27,213 5,599,466 SH   DFND   0 5,599,466 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 16,473 19,141,000 PRN   DFND   0 19,141,000 0
ENVISION HEALTHCARE CORP COM 29414D100 6,729 107,370 SH   DFND   0 107,370 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9,903 213,980 SH   DFND   0 213,980 0
EVOLENT HEALTH INC CL A 30050B101 11,361 448,178 SH   DFND   0 448,178 0
FACEBOOK INC CL A 30303M102 46,230 306,199 SH   DFND   0 306,199 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 9,875 15,675,000 PRN   DFND   0 15,675,000 0
GODADDY INC CL A 380237107 89,406 2,107,643 SH   DFND   0 2,107,643 0
HERON THERAPEUTICS INC COM 427746102 46,322 3,344,517 SH   DFND   0 3,344,517 0
HILL ROM HLDGS INC COM 431475102 11,727 147,304 SH   DFND   0 147,304 0
HUMANA INC COM 444859102 80,922 336,307 SH   DFND   0 336,307 0
ICON PLC SHS G4705A100 21,532 220,190 SH   DFND   0 220,190 0
IGNYTA INC COM 451731103 18,842 1,820,496 SH   DFND   0 1,820,496 0
INTERSECT ENT INC COM 46071F103 11,022 394,338 SH   DFND   0 394,338 0
INVUITY INC COM NEW 46187J205 3,275 451,761 SH   DFND   0 451,761 0
ISHARES TR RUSSELL 2000 464287655 5,327 37,800 SH Put DFND   0 37,800 0
JD COM INC SPON ADR CL A 47215P106 33,051 842,701 SH   DFND   0 842,701 0
JOUNCE THERAPEUTICS INC COM 481116101 9,795 698,159 SH   DFND   0 698,159 0
JUNO THERAPEUTICS INC COM 48205A109 3,428 114,695 SH   DFND   0 114,695 0
KITE PHARMA INC COM 49803L109 180,733 1,743,351 SH   DFND   0 1,743,351 0
KURA ONCOLOGY INC COM 50127T109 18,949 2,037,493 SH   DFND   0 2,037,493 0
LENDINGTREE INC NEW COM 52603B107 12,344 71,685 SH   DFND   0 71,685 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 37,123 1,155,765 SH   DFND   0 1,155,765 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 19,920 1,205,837 SH   DFND   0 1,205,837 0
MCKESSON CORP COM 58155Q103 72,078 438,055 SH   DFND   0 438,055 0
MEDICINES CO COM 584688105 42,085 1,107,200 SH Call DFND   0 1,107,200 0
MEDICINES CO COM 584688105 68,912 1,813,002 SH   DFND   0 1,813,002 0
MEDICINES CO NOTE 2.500% 1/1 584688AE5 13,282 10,183,000 PRN   DFND   0 10,183,000 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 28,247 26,870,000 PRN   DFND   0 26,870,000 0
MERIT MED SYS INC COM 589889104 14,684 384,901 SH   DFND   0 384,901 0
MICROSOFT CORP COM 594918104 81,014 1,175,303 SH   DFND   0 1,175,303 0
MOLINA HEALTHCARE INC COM 60855R100 60,906 880,402 SH   DFND   0 880,402 0
MYOKARDIA INC COM 62857M105 21,871 1,669,524 SH   DFND   0 1,669,524 0
NETEASE INC SPONSORED ADR 64110W102 29,966 99,676 SH   DFND   0 99,676 0
NVIDIA CORP COM 67066G104 14,738 101,949 SH   DFND   0 101,949 0
PACIRA PHARMACEUTICALS INC COM 695127100 87,797 1,840,618 SH   DFND   0 1,840,618 0
PALO ALTO NETWORKS INC COM 697435105 35,794 267,499 SH   DFND   0 267,499 0
PAYPAL HLDGS INC COM 70450Y103 20,148 375,399 SH   DFND   0 375,399 0
PEABODY ENERGY CORP NEW COM 704551100 2,985 122,101 SH   DFND   0 122,101 0
PENUMBRA INC COM 70975L107 37,470 427,005 SH   DFND   0 427,005 0
PERKINELMER INC COM 714046109 40,103 588,540 SH   DFND   0 588,540 0
PORTOLA PHARMACEUTICALS INC COM 737010108 154,234 2,745,842 SH   DFND   0 2,745,842 0
POWERSHARES QQQ TRUST UNIT SERIES 1 73935A954 98,715 717,200 SH Put DFND   0 717,200 0
PRICELINE GRP INC COM NEW 741503403 14,880 7,955 SH   DFND   0 7,955 0
PUMA BIOTECHNOLOGY INC COM 74587V107 27,015 309,100 SH Call DFND   0 309,100 0
PUMA BIOTECHNOLOGY INC COM 74587V107 147,021 1,682,158 SH   DFND   0 1,682,158 0
REGENXBIO INC COM 75901B107 5,364 271,603 SH   DFND   0 271,603 0
S&P GLOBAL INC COM 78409V104 37,760 258,649 SH   DFND   0 258,649 0
SALESFORCE COM INC COM 79466L302 38,857 448,700 SH   DFND   0 448,700 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 130,556 1,647,600 SH Call DFND   0 1,647,600 0
SERVICENOW INC COM 81762P102 65,586 618,736 SH   DFND   0 618,736 0
SPECTRANETICS CORP COM 84760C107 25,935 675,383 SH   DFND   0 675,383 0
SQUARE INC CL A 852234103 19,578 834,542 SH   DFND   0 834,542 0
UNITEDHEALTH GROUP INC COM 91324P102 60,971 328,829 SH   DFND   0 328,829 0
UNIVERSAL HLTH SVCS INC CL B 913903100 91,078 746,051 SH   DFND   0 746,051 0
VISA INC COM CL A 92826C839 52,675 561,690 SH   DFND   0 561,690 0
VOYAGER THERAPEUTICS INC COM 92915B106 7,644 853,125 SH   DFND   0 853,125 0
VULCAN MATLS CO COM 929160109 15,043 118,745 SH   DFND   0 118,745 0
WEATHERFORD INTL LTD NOTE 5.875% 7/0 947075AH0 82,690 81,518,000 PRN   DFND   0 81,518,000 0
ZAYO GROUP HLDGS INC COM 98919V105 33,652 1,089,069 SH   DFND   0 1,089,069 0
ZENDESK INC COM 98936J101 15,294 550,532 SH   DFND   0 550,532 0