The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 36,255 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AC IMMUNE SA SHS H00263105 4,400 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 5,470 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ACCELERON PHARMA INC COM 00434H108 21,273 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
ACHAOGEN INC COM 004449104 4,346 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONSORED ADR 00653A107 1,347 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ADURO BIOTECH INC COM 00739L101 1,140 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
AGENUS INC COM NEW 00847G705 7,820 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 36,015 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 5,145 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 2,056 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 3,435 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 12,167 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 2,543 20,900 SH Call DFND 1,2,3,4,5 20,900 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 21,934 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 14,098 1,400,000 SH   DFND 1,2,3,4,5 1,400,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 5,035 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ANAPTYSBIO INC COM 032724106 5,983 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 7,952 950,000 SH   DFND 1,2,3,4,5 950,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 4,185 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 7,000 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ATHENE HLDG LTD CL A G0684D107 9,922 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AVEXIS INC COM 05366U100 11,502 140,000 SH   DFND 1,2,3,4,5 140,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 4,058 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
BANK AMER CORP COM 060505104 204,997 8,450,000 SH Call DFND 1,2,3,4,5 8,450,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 18,000 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 4,726 850,000 SH   DFND 1,2,3,4,5 850,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 22,705 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,623 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
BIOTIME INC COM 09066L105 4,038 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLUEBIRD BIO INC COM 09609G100 26,263 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
BLUEBIRD BIO INC COM 09609G100 5,253 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 1,994,983 87,460,875 SH   DFND 1,2,3,4 87,460,875 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 55,720 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 2,970 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 1,667 675,000 SH   DFND 1,2,3,4,5 675,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 2,582 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CHEMOCENTRYX INC COM 16383L106 4,680 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CHIMERIX INC COM 16934W106 2,725 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CITIGROUP INC COM NEW 172967424 33,440 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,341 25,000 SH   DFND 1,2,3,4,5 25,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,575 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 340 234,493 SH   DFND 1,2,3,4,5 234,493 0 0
E L F BEAUTY INC COM 26856L103 6,803 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 4,517 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 3,003 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
GILEAD SCIENCES INC COM 375558103 88,475 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 2,735 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 6,838 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
GLYCOMIMETICS INC COM 38000Q102 2,260 202,500 SH   DFND 1,2,3,4,5 202,500 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 22,190 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 321,755 1,450,000 SH Call DFND 1,2,3,4,5 1,450,000 0 0
HORIZON PHARMA PLC SHS G4617B105 9,021 760,000 SH   DFND 1,2,3,4,5 760,000 0 0
HORIZON PHARMA PLC SHS G4617B105 5,935 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
IGNYTA INC COM 451731103 9,315 900,000 SH   DFND 1,2,3,4,5 900,000 0 0
INCYTE CORP COM 45337C102 50,364 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
INCYTE CORP COM 45337C102 25,182 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 4,000 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 30,766 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 6,867 135,000 SH   DFND 1,2,3,4,5 135,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 7,552 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,095 216,879 SH   DFND 1,2,3,4 216,879 0 0
JOUNCE THERAPEUTICS INC COM 481116101 3,508 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 5,978 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 1,495 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
KITE PHARMA INC COM 49803L109 10,367 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 13,050 793,327 SH   DFND 1,2,3,4,5 793,327 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 933,120 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MACROGENICS INC COM 556099109 5,253 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
MEDICINES CO COM 584688105 13,304 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
MEDICINES CO COM 584688105 7,602 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
METLIFE INC COM 59156R108 5,494 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
METLIFE INC COM 59156R108 137,350 2,500,000 SH Call DFND 1,2,3,4,5 2,500,000 0 0
MICROSOFT CORP COM 594918104 68,930 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,224 251,300 SH   DFND 1,2,3,4,5 251,300 0 0
MORGAN STANLEY COM NEW 617446448 22,280 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
NANTKWEST INC COM 63016Q102 1,708 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
NEKTAR THERAPEUTICS COM 640268108 27,370 1,400,000 SH   DFND 1,2,3,4,5 1,400,000 0 0
NEKTAR THERAPEUTICS COM 640268108 19,550 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 25,300 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
NEURODERM LTD ORD SHS M74231107 748 25,000 SH   DFND 1,2,3,4,5 25,000 0 0
NOVAVAX INC COM 670002104 575 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 2,367 256,400 SH   DFND 1,2,3,4,5 256,400 0 0
ONCOCYTE CORPORATION COM 68235C107 780 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 2,600 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 6,785 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
RADIUS HEALTH INC COM NEW 750469207 9,046 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
REGENXBIO INC COM 75901B107 3,160 160,000 SH   DFND 1,2,3,4,5 160,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,168 90,000 SH   DFND 1,2,3,4,5 90,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 5,057 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 3,371 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SEATTLE GENETICS INC. COM 812578102 3,881 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
SEATTLE GENETICS INC. COM 812578102 5,174 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SERES THERAPEUTICS INC COM 81750R102 6,780 600,000 SH   DFND 1,2,3,4,5 600,000 0 0
SPARK THERAPEUTICS INC COM 84652J103 2,987 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,300 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 4,191 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
TERADYNE INC COM 880770102 15,015 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
TESARO INC COM 881569107 6,993 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
TESARO INC COM 881569107 32,867 235,000 SH Call DFND 1,2,3,4,5 235,000 0 0
TG THERAPEUTICS INC COM 88322Q108 5,025 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,106 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
VERASTEM INC COM 92337C104 1,090 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
VERSARTIS INC COM 92529L102 6,108 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
VITAL THERAPIES INC COM 92847R104 2,538 875,000 SH   DFND 1,2,3,4,5 875,000 0 0
WELLS FARGO & CO NEW COM 949746101 36,017 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 983,995 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
XENON PHARMACEUTICALS INC COM 98420N105 473 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ZAFGEN INC COM 98885E103 3,510 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 6,980 500,000 SH   DFND 1,2,3,4,5 500,000 0 0