The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHILLION PHARMACEUTICALS INC COM | COM | 00448Q201 | 13,832 | 3,285,400 | SH | DFND | 1 | 0 | 3,285,400 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 48,246 | 1,738,600 | SH | DFND | 1 | 0 | 1,738,600 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 3,426 | 8,052,073 | SH | DFND | 1 | 0 | 8,052,073 | 0 | |
| ARQULE INC | COM | 04269E107 | 7,844 | 7,400,128 | SH | DFND | 1 | 0 | 7,400,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 24,702 | 2,763,086 | SH | DFND | 1 | 0 | 2,763,086 | 0 | |
| BIOLINERX LTD SPONSORED | SPONSORED ADR | 09071M106 | 16,809 | 17,500,000 | SH | DFND | 1 | 0 | 17,500,000 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 84,070 | 2,102,280 | SH | DFND | 1 | 0 | 2,102,280 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM NEW | 14740B606 | 12,972 | 3,133,224 | SH | DFND | 1 | 0 | 3,133,224 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 58,171 | 7,990,572 | SH | DFND | 1 | 0 | 7,990,572 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 39,863 | 2,336,609 | SH | DFND | 1 | 0 | 2,336,609 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 18,815 | 4,479,691 | SH | DFND | 1 | 0 | 4,479,691 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 54,752 | 4,260,836 | SH | DFND | 1 | 0 | 4,260,836 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 31,167 | 1,804,675 | SH | DFND | 1 | 0 | 1,804,675 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 8,851 | 1,945,245 | SH | DFND | 1 | 0 | 1,945,245 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 29,908 | 1,387,853 | SH | DFND | 1 | 0 | 1,387,853 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 15,347 | 2,826,282 | SH | DFND | 1 | 0 | 2,826,282 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 5,387 | 1,108,433 | SH | DFND | 1 | 0 | 1,108,433 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 8,391 | 1,233,976 | SH | DFND | 1 | 0 | 1,233,976 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 25,408 | 7,866,108 | SH | DFND | 1 | 0 | 7,866,108 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 13,466 | 320,000 | SH | DFND | 1 | 0 | 320,000 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 5,444 | 1,864,474 | SH | DFND | 1 | 0 | 1,864,474 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 16,214 | 1,760,489 | SH | DFND | 1 | 0 | 1,760,489 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 2,528 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750% | 686164AB0 | 5,475 | 10,000,000 | PRN | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 2,035 | 2,278,552 | SH | DFND | 1 | 0 | 2,278,552 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 4,984 | 1,917,033 | SH | DFND | 1 | 0 | 1,917,033 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 1,028 | 623,000 | SH | DFND | 1 | 0 | 623,000 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 6,315 | 1,540,323 | SH | DFND | 1 | 0 | 1,540,323 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 11,799 | 2,949,794 | SH | DFND | 1 | 0 | 2,949,794 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 10,685 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |