The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 2,000 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 1,985 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 23,856 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| ADVANCED ACCELERATOR APPLIC | SPONSORED ADS | 00790T100 | 2,990 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 4,524 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 4,006 | 1,250,000 | SH | DFND | 1 | 1,250,000 | 0 | 0 | |
| ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 22,843 | 1,098,205 | SH | DFND | 1 | 1,098,205 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 24,854 | 895,626 | SH | DFND | 1 | 895,626 | 0 | 0 | |
| APTOSE BIOSCIENCES INC | COM NEW | 03835T200 | 1,010 | 990,579 | SH | DFND | 1 | 990,579 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 24,323 | 1,922,738 | SH | DFND | 1 | 1,922,738 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 8,046 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 2,800 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 7,236 | 424,660 | SH | DFND | 1 | 424,660 | 0 | 0 | |
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 413 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 2,281 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 23,994 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | COM | 15117F302 | 122 | 53,649 | SH | DFND | 1 | 53,649 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | *W EXP 08/20/201 | 15117F120 | 20 | 52,999 | SH | DFND | 1 | 52,999 | 0 | 0 | |
| CHINA BIOLOGIC PRODUCTS INC | COM | 16938C106 | 10,013 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 15,411 | 1,940,880 | SH | DFND | 1 | 1,940,880 | 0 | 0 | |
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 13,119 | 620,300 | SH | DFND | 1 | 620,300 | 0 | 0 | |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 3,018 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 6,390 | 3,550,000 | SH | DFND | 1 | 3,550,000 | 0 | 0 | |
| CORBUS PHARMACEUTICALS HLDGS | COM | 21833P103 | 13,910 | 1,686,100 | SH | DFND | 1 | 1,686,100 | 0 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 1,682 | 81,000 | SH | DFND | 1 | 81,000 | 0 | 0 | |
| CURIS INC | COM | 231269101 | 5,560 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 3,972 | 230,000 | SH | DFND | 1 | 230,000 | 0 | 0 | |
| DERMIRA INC | COM | 24983L104 | 5,799 | 170,000 | SH | DFND | 1 | 170,000 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 5,931 | 70,000 | SH | DFND | 1 | 70,000 | 0 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 16,588 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| EPIZYME INC | COM | 29428V104 | 2,401 | 140,000 | SH | DFND | 1 | 140,000 | 0 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 12,697 | 589,175 | SH | DFND | 1 | 589,175 | 0 | 0 | |
| FULGENT GENETICS INC | COM | 359664109 | 8,190 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 26,070 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| GEMPHIRE THERAPEUTICS INC | COM | 36870A108 | 10,004 | 952,798 | SH | DFND | 1 | 952,798 | 0 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 1,559 | 287,031 | SH | DFND | 1 | 287,031 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 18,000 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| HTG MOLECULAR DIAGNOSTICS IN | COM | 40434H104 | 1,408 | 203,464 | SH | DFND | 1 | 203,464 | 0 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 2,292 | 337,000 | SH | DFND | 1 | 337,000 | 0 | 0 | |
| INC RESH HLDGS INC | CL A | 45329R109 | 9,170 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| INTEC PHARMA LTD JERUSALEM | SHS | M53644106 | 4,140 | 809,804 | SH | DFND | 1 | 809,804 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 6,014 | 756,470 | SH | DFND | 1 | 756,470 | 0 | 0 | |
| JOUNCE THERAPEUTICS INC | COM | 481116101 | 9,565 | 434,976 | SH | DFND | 1 | 434,976 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 14,424 | 650,000 | SH | DFND | 1 | 650,000 | 0 | 0 | |
| LIPOCINE INC | COM | 53630X104 | 2,892 | 741,496 | SH | DFND | 1 | 741,496 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 18,694 | 2,307,903 | SH | DFND | 1 | 2,307,903 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 14,860 | 1,130,000 | SH | DFND | 1 | 1,130,000 | 0 | 0 | |
| MYOVANT SCIENCES LTD | COM | G637AM102 | 1,174 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 364 | 50,613 | SH | DFND | 1 | 50,613 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 12,990 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 32,795 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 11,340 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| ONCOBIOLOGICS INC | COM | 68235M105 | 2,687 | 1,002,516 | SH | DFND | 1 | 1,002,516 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 02/18/201 | 68235M113 | 333 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 05/18/201 | 68235M121 | 208 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PFENEX INC | COM | 717071104 | 3,341 | 574,966 | SH | DFND | 1 | 574,966 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 23,514 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 8,757 | 683,600 | SH | DFND | 1 | 683,600 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 29,747 | 3,804,027 | SH | DFND | 1 | 3,804,027 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 20,264 | 2,899,000 | SH | DFND | 1 | 2,899,000 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 5,157 | 590,000 | SH | DFND | 1 | 590,000 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 2,316 | 120,000 | SH | DFND | 1 | 120,000 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 6,620 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 3,120 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 6,679 | 1,690,800 | SH | DFND | 1 | 1,690,800 | 0 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 2,133 | 520,183 | SH | DFND | 1 | 520,183 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 3,298 | 240,403 | SH | DFND | 1 | 240,403 | 0 | 0 | |
| SYNERGY PHARMACEUTICALS INC | COM NEW | 871639308 | 5,592 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 52,469 | 1,425,000 | SH | DFND | 1 | 1,425,000 | 0 | 0 | |
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 513 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| TIGENIX | SPONSORED ADS | 88675R109 | 2,013 | 129,032 | SH | DFND | 1 | 129,032 | 0 | 0 | |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 5,084 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 13,257 | 482,079 | SH | DFND | 1 | 482,079 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 1,794 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| ZYNERBA PHARMACEUTICALS INC | COM | 98986X109 | 10,050 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |