The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COMMON 003654100 32,764 261,691 SH   SOLE   151,492 0 110,199
ACADIA HEALTHCARE COMMON 00404A109 30,128 691,010 SH   SOLE   445,510 0 245,500
ACADIA PHARMACEUTICALS COMMON 004225108 23,073 671,113 SH   SOLE   359,277 0 311,836
ACCELERON PHARMA COMMON 00434H108 3,346 126,400 SH   SOLE   0 0 126,400
ACCURAY INC COMMON 004397105 11,792 2,482,621 SH   SOLE   1,069,793 0 1,412,828
ADVAXIS INC COMMON 007624208 6,861 839,774 SH   SOLE   190,251 0 649,523
AERIE PHARMACEUTICALS COMMON 00771V108 17,660 389,423 SH   SOLE   209,223 0 180,200
AGIOS PHARMACEUTICALS COMMON 00847X104 2,990 51,200 SH   SOLE   51,200 0 0
ALBIREO PHARMA INC COMMON 01345P106 485 20,224 SH   SOLE   20,224 0 0
ALDER BIOPHARMACEUTICALS COMMON 014339105 14,833 713,119 SH   SOLE   378,619 0 334,500
ALNYLAM PHARMACEUTICALS COMMON 02043Q107 1,276 24,899 SH   SOLE   24,899 0 0
AMICUS THERAPEUTICS COMMON 03152W109 30,742 4,311,696 SH   SOLE   2,355,171 0 1,956,525
AVEXIS INC COMMON 05366U100 1,137 14,950 SH   SOLE   14,950 0 0
BIOGEN INC COMMON 09062X103 3,202 11,711 SH   SOLE   11,711 0 0
BIOMARIN PHARMAC INC COMMON 09061G101 27,671 315,233 SH   SOLE   315,233 0 0
CELGENE CORP COMMON 151020104 33,853 272,066 SH   SOLE   272,066 0 0
CELLDEX THERAPEUTICS COMMON 15117B103 914 253,178 SH   SOLE   253,178 0 0
COLLEGIUM PHARMACEUTICAL COMMON 19459J104 12,869 1,279,247 SH   SOLE   865,356 0 413,891
CORVUS PHARMACEUTICALS COMMON 221015100 1,396 67,200 SH   SOLE   67,200 0 0
DBV TECHNOLOGIES SP ADR 23306J101 4,702 133,499 SH   SOLE   45,700 0 87,799
DEXCOM INC COMMON 252131107 30,278 357,341 SH   SOLE   230,530 0 126,811
DR REDDYS LABS LTD ADR 256135203 1,291 32,155 SH   SOLE   32,155 0 0
EDWARDS LIFESCIENCE COMMON 28176E108 18,859 200,479 SH   SOLE   200,479 0 0
ENDO INTL PLC SHS G30401106 8,148 730,150 SH   SOLE   730,150 0 0
ENVISION HEALTHCARE COMMON 29414D100 7,668 125,050 SH   SOLE   150 0 124,900
GLOBAL BLOOD THERAPEUTICS COMMON 37890U108 12,735 345,582 SH   SOLE   213,382 0 132,200
ILLUMINA INC COMMON 452327109 1,937 11,350 SH   SOLE   11,350 0 0
INCYTE CORPORATION COMMON 45337C102 2,292 17,145 SH   SOLE   17,145 0 0
INSMED INC COMMON 457669307 1,937 110,599 SH   SOLE   110,599 0 0
INTEGRA LIFESCIENCE COMMON 457985208 8,531 202,499 SH   SOLE   0 0 202,499
INTERSECT ENT INC COMMON 46071F103 2,457 143,240 SH   SOLE   0 0 143,240
INTUITIVE SURGIC INC COMMON 46120E602 21,976 28,672 SH   SOLE   28,672 0 0
JOHNSON & JOHNSON COMMON 478160104 42,640 342,350 SH   SOLE   342,350 0 0
K2M GROUP HOLDINGS COMMON 48273J107 17,157 836,520 SH   SOLE   417,820 0 418,700
KITE PHARMA INC COMMON 49803L109 4,986 63,520 SH   SOLE   0 0 63,520
LA JOLLA PHARMACEUTICAL COMMON 503459604 2,349 78,700 SH   SOLE   78,700 0 0
LOXO ONCOLOGY INC COMMON 548862101 3,804 90,390 SH   SOLE   24,390 0 66,000
MASIMO CORP COMMON 574795100 4,971 53,300 SH   SOLE   0 0 53,300
MERCK & CO INC COMMON 58933Y105 45,811 720,982 SH   SOLE   720,982 0 0
MOLINA HEALTHCARE COMMON 60855R100 3,720 81,575 SH   SOLE   175 0 81,400
MOMENTA PHARMACEUTICALS COMMON 60877T100 6,145 460,300 SH   SOLE   800 0 459,500
MYLAN N V SHS EURO N59465109 23,813 610,743 SH   SOLE   610,743 0 0
NEUROCRINE BIOSCIENCES COMMON 64125C109 36,849 851,019 SH   SOLE   531,619 0 319,400
NEURODERM LTD ORD SHS M74231107 12,990 489,267 SH   SOLE   351,467 0 137,800
NOVARTIS AG SP ADR 66987V109 35,077 472,296 SH   SOLE   472,296 0 0
NOVO-NORDISK AS ADR 670100205 7,455 217,480 SH   SOLE   217,480 0 0
NUVASIVE INC COMMON 670704105 29,274 391,989 SH   SOLE   224,489 0 167,500
NXSTAGE MEDICAL COMMON 67072V103 13,538 504,568 SH   SOLE   223,324 0 281,244
OBSEVA SA COMMON H5861P103 786 75,500 SH   SOLE   75,500 0 0
PFIZER INC COMMON 717081103 39,320 1,149,372 SH   SOLE   1,149,372 0 0
PORTOLA PHARMACEUTICALS COMMON 737010108 23,672 604,041 SH   SOLE   316,599 0 287,442
PROFOUND MEDICAL COMMON 74319B106 387 495,900 SH   SOLE   495,900 0 0
PROTHENA CORP PLC SHS G72800108 7,869 141,046 SH   SOLE   23,646 0 117,400
PTC THERAPEUTICS I COMMON 69366J200 3,455 351,135 SH   SOLE   103,735 0 247,400
RA PHARMACEUTICALS COMMON 74933V108 4,797 225,340 SH   SOLE   77,900 0 147,440
REGENERON PHARMACEUTICALS COMMON 75886F107 2,207 5,695 SH   SOLE   5,695 0 0
SAGE THERAPEUTICS COMMON 78667J108 867 12,199 SH   SOLE   12,199 0 0
SAREPTA THERAPEUTICS COMMON 803607100 852 28,799 SH   SOLE   28,799 0 0
SHIRE PLC SP ADR 82481R106 30,260 173,679 SH   SOLE   173,679 0 0
SIERRA ONCOLOGY INC COMMON 82640U107 309 201,660 SH   SOLE   201,660 0 0
TELADOC INC COMMON 87918A105 26,464 1,058,553 SH   SOLE   604,275 0 454,278
TEVA PHARMACEUTICAL SP ADR 881624209 24,190 753,821 SH   SOLE   753,821 0 0
TG THERAPEUTICS COMMON 88322Q108 1,602 137,500 SH   SOLE   137,500 0 0
TRILLIUM THERAPEUTICS COMMON 89620X506 789 128,272 SH   SOLE   128,272 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 18,088 581,222 SH   SOLE   181,950 0 399,272