The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 59,171 10,778,004 SH   DFND 5,18 10,778,004 0 0
AC IMMUNE SA SHS H00263105 13,857 1,337,500 SH   DFND 8,17,20 1,337,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 148,717 1,226,630 SH   DFND 2,8,11 1,226,630 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,827,457 35,495,289 SH   DFND 1,4,14,15,16 35,495,289 0 0
AMAZON COM INC COM 023135106 116,788 131,735 SH   DFND 1,14,16 131,735 0 0
AMYRIS INC COM 03236M101 27,469 51,828,214 SH   DFND 2,8,11 51,828,214 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 6,800 10,000,000 PRN   DFND 2,8,11 10,000,000 0 0
ANTERO RES CORP COM 03674X106 222,526 9,755,618 SH   DFND 6,16 9,755,618 0 0
ATHENE HLDG LTD CL A G0684D107 115,612 2,312,694 SH   DFND 4,12,14,16 2,312,694 0 0
BEIGENE LTD SPONSORED ADR 07725L102 13,912 380,000 SH   DFND 8,17,20 380,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 304,835 3,472,712 SH   DFND 2,8,11,17,20 3,472,712 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 649 10,900 SH   DFND 1,14,16 10,900 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 260,358 5,297,205 SH   DFND 4,6,14,16 5,297,205 0 0
DELL TECHNOLOGIES INC COM CL V 24703L103 77,291 1,206,167 SH   DFND 4,13,14,16 1,206,167 0 0
EROS INTL PLC SHS NEW G3788M114 28,380 2,755,310 SH   DFND 4,13,14,16 2,755,310 0 0
GILEAD SCIENCES INC COM 375558103 981,051 14,444,216 SH   DFND 1,8,14,16,17,20 14,444,216 0 0
ICICI BK LTD ADR 45104G104 21,961 2,553,625 SH   DFND 2,8 2,553,625 0 0
IHS MARKIT LTD SHS G47567105 888,220 21,173,310 SH   DFND 5,18 21,173,310 0 0
ILLUMINA INC COM 452327109 47,312 277,261 SH   DFND 1,14,16 277,261 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 11,139 790,527 SH   DFND 6,8,16,17 790,527 0 0
JD COM INC SPON ADR CL A 47215P106 227,307 7,306,572 SH   DFND 6,16 7,306,572 0 0
JUNO THERAPEUTICS INC COM 48205A109 20,320 915,750 SH   DFND 8,17,20 915,750 0 0
LEVEL 3 COMMUNICATIONS INC COM NEW 52729N308 3,721,112 65,031,667 SH   DFND   65,031,667 0 0
MARIN SOFTWARE INC COM 56804T106 4,551 2,528,205 SH   DFND 4,14,15,16 2,528,205 0 0
MASTERCARD INCORPORATED CL A 57636Q104 30,030 267,006 SH   DFND 1,14,16 267,006 0 0
NQ MOBILE INC ADR REPSTG CL A 64118U108 1,015 243,458 SH   DFND 4,14,16 243,458 0 0
PAYPAL HLDGS INC COM 70450Y103 231,790 5,387,963 SH   DFND 4,8,10,14,16 5,387,963 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 258,010 6,583,568 SH   DFND 2,8,11,17,20 6,583,568 0 0
PPG INDS INC COM 693506107 181,541 1,727,645 SH   DFND 1,14,16 1,727,645 0 0
REGENERON PHARMACEUTICALS COM 75886F107 48,962 126,351 SH   DFND 8,17,20 126,351 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 22,809 408,543 SH   DFND 6,16 408,543 0 0
SENSEONICS HLDGS INC COM 81727U105 506 282,582 SH   DFND 7 282,582 0 0
SNAP INC CL A 83304A106 6,759 300,000 SH   DFND 1,14,16 300,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 248,016 1,614,687 SH   DFND 2,8,11 1,614,687 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 71,783 8,194,444 SH   DFND 5,18 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 224,767 73,213,884 SH   DFND 3,18,19 73,213,884 0 0
UNIVAR INC COM 91336L107 434,317 14,165,603 SH   DFND 3,18,19 14,165,603 0 0
VIRTU FINL INC CL A 928254101 209,401 12,317,682 SH   DFND 7,9 12,317,682 0 0
VISA INC COM CL A 92826C839 135,286 1,522,287 SH   DFND 1,14,16 1,522,287 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 159,394 12,176,750 SH   DFND 1,14,16 12,176,750 0 0