The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 2,647 100,000 SH   DFND 1,2 100,000 0 0
ACHAOGEN INC COM 004449104 5,046 200,000 SH   DFND 1,2 200,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 3,421 195,500 SH   DFND 1,2 195,500 0 0
ADVANCE AUTO PARTS INC CALL 00751Y906 2,843 200 SH Call DFND   0 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 1,666 11,237 SH   DFND   11,237 0 0
AEVI GENOMIC MEDICINE INC COM 00835P105 753 405,000 SH   DFND 1,2 405,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 3,343 668,500 SH   DFND 1,2 668,500 0 0
ALPHABET INC CAP STK CL A 02079K305 3,685 4,346 SH   DFND   4,346 0 0
AMICUS THERAPEUTICS INC COM 03152W109 3,565 500,000 SH   DFND 1,2 500,000 0 0
ANAPTYSBIO INC COM 032724106 708 25,500 SH   DFND 1,2 25,500 0 0
ARDELYX INC COM 039697107 4,364 345,000 SH   DFND 1,2 345,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 6,258 700,000 SH   DFND 1,2 700,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 7,153 255,455 SH   DFND 1,2 255,455 0 0
ATHERSYS INC COM 04744L106 1 773 SH   DFND 1,2 773 0 0
AVEO PHARMACEUTICALS INC COM 053588109 1,711 2,900,000 SH   DFND 1,2 2,900,000 0 0
AVEXIS INC COM 05366U100 3,421 45,000 SH   DFND 1,2 45,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 1,564 401,000 SH   DFND 1,2 401,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 2,468 200,000 SH   DFND 1,2 200,000 0 0
BIOGEN INC COM 09062X103 20,507 75,000 SH   DFND 1,2 75,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 8,157 150,000 SH   DFND 1,2 150,000 0 0
CAESARSTONE LTD ORD SHS M20598104 3,262 89,974 SH   DFND   89,974 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 2,406 581,210 SH   DFND 1,2 581,210 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 621 388,030 SH   DFND 1,2 388,030 0 0
CELGENE CORP CALL 151020904 14,886 1,200 SH Call DFND 1,2 0 0 0
CELGENE CORP COM 151020104 31,108 250,000 SH   DFND 1,2 250,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 3,832 159,664 SH   DFND 1,2 159,664 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 3,915 11,960 SH   DFND   11,960 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 178 400 SH   DFND   400 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 2,382 300,000 SH   DFND 1,2 300,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 5,798 279,166 SH   DFND 1,2 279,166 0 0
CYTOKINETICS INC COM NEW 23282W605 1,956 152,200 SH   DFND 1,2 152,200 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 2,591 150,000 SH   DFND 1,2 150,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 3,176 90,167 SH   DFND 1,2 90,167 0 0
EDGE THERAPEUTICS INC COM 279870109 1,367 150,000 SH   DFND 1,2 150,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,412 385,301 SH   DFND 1,2 385,301 0 0
EVOKE PHARMA INC COM 30049G104 1,550 500,000 SH   DFND 1,2 500,000 0 0
FACEBOOK INC CL A 30303M102 2,570 18,092 SH   DFND   18,092 0 0
FIBROGEN INC COM 31572Q808 4,085 165,700 SH   DFND 1,2 165,700 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,446 40,000 SH   DFND 1,2 40,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,198 242,000 SH   DFND 1,2 242,000 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 2,328 108,023 SH   DFND 1,2 108,023 0 0
GENOCEA BIOSCIENCES INC COM 372427104 3,936 646,273 SH   DFND 1,2 646,273 0 0
GLYCOMIMETICS INC COM 38000Q102 4,213 775,796 SH   DFND 1,2 775,796 0 0
HERON THERAPEUTICS INC COM 427746102 3,750 250,000 SH   DFND 1,2 250,000 0 0
HORIZON PHARMA PLC SHS G4617B105 7,094 480,000 SH   DFND 1,2 480,000 0 0
IMMUNOMEDICS INC COM 452907108 6,147 950,000 SH   DFND 1,2 950,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 804 401,764 SH   DFND 1,2 401,764 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,697 15,000 SH   DFND 1,2 15,000 0 0
ISHARES TR PUT 464287955 6,953 500 SH Put DFND   500 0 0
ISHARES TR CALL 464287905 1,391 100 SH Call DFND   0 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 8,680 281,356 SH   DFND   281,356 0 0
KITE PHARMA INC COM 49803L109 2,747 35,000 SH   DFND 1,2 35,000 0 0
KORNIT DIGITAL LTD SHS M6372Q113 17 900 SH   DFND   900 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3,284 110,000 SH   DFND 1,2 110,000 0 0
LOWES COS INC COM 548661107 214 2,600 SH   DFND   2,600 0 0
MACROGENICS INC COM 556099109 1,510 81,200 SH   DFND 1,2 81,200 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 2,357 1,331,421 SH   DFND 1,2 1,331,421 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,296 11,525 SH   DFND   11,525 0 0
MERCK & CO INC COM 58933Y105 18,744 295,000 SH   DFND 1,2 295,000 0 0
MOHAWK INDS INC COM 608190104 252 1,100 SH   DFND   1,100 0 0
NEUROCRINE BIOSCIENCES INC PUT 64125C959 8,010 1,500 SH Put DFND 1,2 1,500 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 6,495 150,000 SH   DFND 1,2 150,000 0 0
NICE LTD SPONSORED ADR 653656108 4,318 63,520 SH   DFND   63,520 0 0
NOVARTIS A G SPONSORED ADR 66987V109 18,959 255,000 SH   DFND 1,2 255,000 0 0
OBSEVA SA COM H5861P103 2,197 211,086 SH   DFND 1,2 211,086 0 0
ORBOTECH LTD ORD M75253100 5,066 157,096 SH   DFND   157,096 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 952 2,906,037 SH   DFND 1,2 2,906,037 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 2,695 140,000 SH   DFND 1,2 140,000 0 0
PFIZER INC COM 717081103 13,342 390,000 SH   DFND 1,2 390,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 2,600 1,000,000 SH   DFND 1,2 1,000,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,650 330,000 SH   DFND 1,2 330,000 0 0
PROSHARES TR PSHS ULTSH 20YRS 74347B201 2,189 55,950 SH   DFND   55,950 0 0
RA PHARMACEUTICALS INC COM 74933V108 1,277 60,000 SH   DFND 1,2 60,000 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 935 778,800 SH   DFND 1,2 778,800 0 0
RETROPHIN INC COM 761299106 3,861 209,131 SH   DFND 1,2 209,131 0 0
SAGE THERAPEUTICS INC COM 78667J108 3,554 50,000 SH   DFND 1,2 50,000 0 0
SAPIENS INTL CORP N V SHS NEW N7716A151 1,897 147,306 SH   DFND   147,306 0 0
SAREPTA THERAPEUTICS INC COM 803607100 14,298 483,047 SH   DFND 1,2 483,047 0 0
SCHLUMBERGER LTD COM 806857108 2,727 34,911 SH   DFND   34,911 0 0
SEALED AIR CORP NEW COM 81211K100 196 4,500 SH   DFND   4,500 0 0
SEATTLE GENETICS INC COM 812578102 2,263 36,000 SH   DFND 1,2 36,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 3,273 228,534 SH   DFND 1,2 228,534 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 209 5,000 SH   DFND   5,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 15,424 214,539 SH   DFND 1,2 214,539 0 0
SNAP ON INC COM 833034101 2,664 15,797 SH   DFND   15,797 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 729 46,750 SH   DFND   46,750 0 0
SPDR S&P 500 ETF TR PUT 78462F953 23,808 1,000 SH Put DFND   1,000 0 0
SPDR SERIES TRUST PUT 78464A950 57,152 8,000 SH Put DFND 1,2 8,000 0 0
STARBUCKS CORP COM 855244109 2,723 46,631 SH   DFND   46,631 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,565 300,000 SH   DFND 1,2 300,000 0 0
SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1,967 147,450 SH   DFND 1,2 147,450 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 513 125,000 SH   DFND 1,2 125,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,282 166,310 SH   DFND 1,2 166,310 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 3,800 6,585 SH   DFND   6,585 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624909 4,737 1,500 SH Call DFND   0 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 5,519 172,000 SH   DFND 1,2 172,000 0 0
THERAPEUTICSMD INC COM 88338N107 4,176 580,000 SH   DFND 1,2 580,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,062 6,913 SH   DFND   6,913 0 0
TJX COS INC NEW COM 872540109 1,795 22,700 SH   DFND   22,700 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 1,548 67,155 SH   DFND   67,155 0 0
TREVENA INC COM 89532E109 429 116,800 SH   DFND 1,2 116,800 0 0
TRIPADVISOR INC COM 896945201 173 4,000 SH   DFND   4,000 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 156 800 SH   DFND   800 0 0
UNION PAC CORP COM 907818108 3,037 28,670 SH   DFND   28,670 0 0
UNITEDHEALTH GROUP INC COM 91324P102 328 2,000 SH   DFND   2,000 0 0
VERSARTIS INC COM 92529L102 6,405 300,000 SH   DFND 1,2 300,000 0 0
VISA INC COM CL A 92826C839 4,706 52,951 SH   DFND   52,951 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,066 544,100 SH   DFND 1,2 544,100 0 0
VTV THERAPEUTICS INC CL A 918385105 1,965 300,000 SH   DFND 1,2 300,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,312 328,029 SH   DFND 1,2 328,029 0 0
ZOGENIX INC COM NEW 98978L204 1,085 100,000 SH   DFND 1,2 100,000 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 2,010 100,000 SH   DFND 1,2 100,000 0 0