The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHILLION PHARMACEUTICALS INC COM | COM | 00448Q201 | 10,008 | 2,423,300 | SH | DFND | 1 | 0 | 2,423,300 | 0 | |
| ADURO BIOTECH INC | COM | 00739L101 | 8,503 | 745,886 | SH | DFND | 1 | 0 | 745,886 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 40 | 62,292 | SH | DFND | 1 | 0 | 62,292 | 0 | |
| ARQULE INC | COM | 04269E107 | 9,324 | 7,400,128 | SH | DFND | 1 | 0 | 7,400,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 43,829 | 4,986,186 | SH | DFND | 1 | 0 | 4,986,186 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 91,311 | 3,255,280 | SH | DFND | 1 | 0 | 3,255,280 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM NEW | 14740B606 | 13,504 | 3,133,224 | SH | DFND | 1 | 0 | 3,133,224 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 57,709 | 7,798,572 | SH | DFND | 1 | 0 | 7,798,572 | 0 | |
| COLUCID PHARMACEUTICALS INC | COM | 19716T101 | 17,630 | 484,335 | SH | DFND | 1 | 0 | 484,335 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 26,921 | 2,616,249 | SH | DFND | 1 | 0 | 2,616,249 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L106 | 18,053 | 44,796,940 | SH | DFND | 1 | 0 | 44,796,940 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 58,948 | 4,851,691 | SH | DFND | 1 | 0 | 4,851,691 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 6,097 | 554,806 | SH | DFND | 1 | 0 | 554,806 | 0 | |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 8,924 | 712,770 | SH | DFND | 1 | 0 | 712,770 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 9,436 | 3,759,398 | SH | DFND | 1 | 0 | 3,759,398 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 20,832 | 1,387,853 | SH | DFND | 1 | 0 | 1,387,853 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 17,240 | 2,826,282 | SH | DFND | 1 | 0 | 2,826,282 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 5,853 | 1,108,433 | SH | DFND | 1 | 0 | 1,108,433 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 7,261 | 1,320,164 | SH | DFND | 1 | 0 | 1,320,164 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 10,612 | 7,860,808 | SH | DFND | 1 | 0 | 7,860,808 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 4,176 | 1,864,474 | SH | DFND | 1 | 0 | 1,864,474 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 13,573 | 1,760,489 | SH | DFND | 1 | 0 | 1,760,489 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 1,279 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750% 20 | 686164AB0 | 3,000 | 10,000,000 | PRN | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 1,299 | 2,278,552 | SH | DFND | 1 | 0 | 2,278,552 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 2,606 | 1,854,768 | SH | DFND | 1 | 0 | 1,854,768 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 5,042 | 1,392,720 | SH | DFND | 1 | 0 | 1,392,720 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 23,437 | 3,043,805 | SH | DFND | 1 | 0 | 3,043,805 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 1,278 | 302,800 | SH | DFND | 1 | 0 | 302,800 | 0 | |