The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105 3,245 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ACCELERON PHARMA INC COM 00434H108 3,828 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ACHAOGEN INC COM 004449104 781 60,000 SH   DFND 1,2,3,4,5 60,000 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 1,215 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ADURO BIOTECH INC COM 00739L101 1,140 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
AGENUS INC COM NEW 00847G705 8,240 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
AGENUS INC COM NEW 00847G705 2,060 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 31,298 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 25,038 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 1,669 81,600 SH   DFND 1,2,3,4,5 81,600 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 24,470 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 42,823 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 21,953 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 18,720 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 7,488 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 8,698 1,750,000 SH   DFND 1,2,3,4,5 1,750,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 3,231 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 10,988 1,250,000 SH   DFND 1,2,3,4,5 1,250,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 7,100 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ATHENE HLDG LTD CL A G0684D107 19,196 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
AVEXIS INC COM 05366U100 7,160 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 3,726 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
BANK AMER CORP COM 060505104 35,360 1,600,000 SH Call DFND 1,2,3,4,5 1,600,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 9,108 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
BIOGEN INC COM 09062X103 42,537 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 28,994 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 12,426 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
BIOTIME INC COM 09066L105 4,628 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLUEBIRD BIO INC COM 09609G100 26,070 422,536 SH   DFND 1,2,3,4,5 422,536 0 0
BLUEBIRD BIO INC COM 09609G100 6,170 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 2,102,559 87,460,875 SH   DFND 1,2,3,4 87,460,875 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 46,752 800,000 SH Call DFND 1,2,3,4,5 800,000 0 0
CELGENE CORP COM 151020104 11,575 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CELGENE CORP COM 151020104 81,025 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 2,390 675,000 SH   DFND 1,2,3,4,5 675,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 2,543 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
CEMPRA INC COM 15130J109 560 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
CHEMOCENTRYX INC COM 16383L106 4,042 546,278 SH   DFND 1,2,3,4,5 546,278 0 0
CHIMERIX INC COM 16934W106 2,300 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 43,392 115,000 SH Call DFND 1,2,3,4,5 115,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,221 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 203 5,575 SH   DFND 1,2,3,4 5,575 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 1,020 234,493 SH   DFND 1,2,3,4,5 234,493 0 0
E L F BEAUTY INC COM 26856L103 4,341 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
LILLY ELI & CO COM 532457108 14,710 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 3,555 246,054 SH   DFND 1,2,3,4,5 246,054 0 0
HORIZON PHARMA PLC SHS G4617B105 8,090 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
IGNYTA INC COM 451731103 4,505 850,000 SH   DFND 1,2,3,4,5 850,000 0 0
INCYTE CORP COM 45337C102 65,176 650,000 SH   DFND 1,2,3,4,5 650,000 0 0
INCYTE CORP COM 45337C102 10,027 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,278 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 16,599 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 9,566 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,587 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,316 216,879 SH   DFND 1,2,3,4 216,879 0 0
ISHARES TR CHINA LG-CAP ETF 464287184 34,710 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
JD COM INC SPON ADR CL A 47215P106 6,360 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
JPMORGAN CHASE & CO COM 46625H100 51,774 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 3,770 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 1,885 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
KITE PHARMA INC COM 49803L109 11,210 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 10,972 793,327 SH   DFND 1,2,3,4,5 793,327 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 784,502 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
LOXO ONCOLOGY INC COM 548862101 3,212 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MACROGENICS INC COM 556099109 4,088 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MEDICINES CO COM 584688105 1,697 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
METLIFE INC COM 59156R108 94,308 1,750,000 SH Call DFND 1,2,3,4,5 1,750,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,953 251,300 SH   DFND 1,2,3,4,5 251,300 0 0
MORGAN STANLEY COM NEW 617446448 6,338 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
NANTKWEST INC COM 63016Q102 1,287 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
NEKTAR THERAPEUTICS COM 640268108 12,270 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
NEKTAR THERAPEUTICS COM 640268108 6,135 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,805 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,870 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
NOVAVAX INC COM 670002104 630 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 2,159 256,400 SH   DFND 1,2,3,4,5 256,400 0 0
ONCOCYTE CORPORATION COM 68235C107 452 64,102 SH   DFND 1,2,3,4,5 64,102 0 0
PFIZER INC COM 717081103 16,240 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 3,803 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 66,076 180,000 SH Call DFND 1,2,3,4,5 180,000 0 0
REGENXBIO INC COM 75901B107 2,968 160,000 SH   DFND 1,2,3,4,5 160,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,659 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 5,486 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 16,458 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
SERES THERAPEUTICS INC COM 81750R102 6,930 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
SPARK THERAPEUTICS INC COM 84652J103 2,495 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,516 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 14,734 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
WAL-MART STORES INC COM 931142103 34,560 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 337,126 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
WELLS FARGO & CO NEW COM 949746101 55,110 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
ZAFGEN INC COM 98885E103 1,590 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 12,070 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0