The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES Common Stock 002824100 1,946 46,019 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC Common Stock 00289Y107 8,016 1,336,050 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC-CW19 WARRANTS 00289y115 4,093 1,259,636 SH   SOLE   0 0 0
ABIOMED INC Common Stock 003654100 8,138 63,290 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC Common Stock 004225108 2,075 65,240 SH   SOLE   0 0 0
ACASTI PHARMA INC Common Stock 00430K402 414 236,559 SH   SOLE   0 0 0
ACCELERON PHARMA INC Common Stock 00434H108 21,348 589,890 SH   SOLE   0 0 0
ACCRETIVE HEALTH INC Common Stock 00438V103 305 125,000 SH   SOLE   0 0 0
ACCURAY INC Common Stock 004397105 174 27,300 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS INC Common Stock 00444T100 21,040 5,408,728 SH   SOLE   0 0 0
ACETO CORP Common Stock 004446100 115 6,054 SH   SOLE   0 0 0
ACHILLION PHARMACEUTICALS Common Stock 00448Q201 7,527 929,290 SH   SOLE   0 0 0
ACLARIS THERAPEUTICS INC Common Stock 00461U105 11,012 430,000 SH   SOLE   0 0 0
ADMA BIOLOGICS INC Common Stock 000899104 5,327 734,793 SH   SOLE   0 0 0
AEGLEA BIOTHERAPEUTICS INC Common Stock 00773J103 664 103,585 SH   SOLE   0 0 0
AERIE PHARMACEUTICALS INC Common Stock 00771V108 15,352 406,771 SH   SOLE   0 0 0
AETNA INC Common Stock 00817Y108 514 4,454 SH   SOLE   0 0 0
AFFIMED NV Common Stock N01045108 2,041 734,301 SH   SOLE   0 0 0
AGENUS INC Common Stock 00847G705 6,462 900,000 SH   SOLE   0 0 0
AGILE THERAPEUTICS INC Common Stock 00847L100 7,120 1,020,011 SH   SOLE   0 0 0
AGILENT TECHNOLOGIES INC Common Stock 00846U101 496 10,540 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS INC Common Stock 00972D105 7,295 809,096 SH   SOLE   0 0 0
ALBANY MOLECULAR RESEARCH Common Stock 012423109 170 10,300 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS INC Common Stock 014339105 12,822 391,280 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS INC Common Stock 01438T106 15,174 1,940,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC Common Stock 019621200 1,537 1,921,951 SH   SOLE   0 0 0
ALLON THERAPEUTICS INC Common Stock 019774108 0 751,124 SH   SOLE   0 0 0
ALMOST FAMILY INC Common Stock 020409108 439 11,942 SH   SOLE   0 0 0
AMAG PHARMACEUTICALS INC Common Stock 00163U106 479 19,524 SH   SOLE   0 0 0
AMARIN CORP PLC-ADR Depository Receipt 023111206 5,175 1,622,280 SH   SOLE   0 0 0
AMERISOURCEBERGEN CORP Common Stock 03073E105 525 6,500 SH   SOLE   0 0 0
AMICUS THERAPEUTICS INC Common Stock 03152W109 104,463 14,116,644 SH   SOLE   0 0 0
AMN HEALTHCARE INC Common Stock 001744101 428 13,445 SH   SOLE   0 0 0
AMSURG CORP Common Stock 03232P405 444 6,618 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC Common Stock 00182C103 767 11,561 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000% 00182CAA1 9,279 7,500,000 PRN   SOLE   0 0 0
ANTARES PHARMA INC Common Stock 036642106 912 0 SH   SOLE   0 0 0
ANTHEM INC Common Stock 036752103 426 3,400 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC Common Stock 03674U201 4,598 1,459,627 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOLOGIES Common Stock 03820J100 4,167 426,048 SH   SOLE   0 0 0
APTEVO THERAPEUTICS INC Common Stock 03835L108 2,530 988,133 SH   SOLE   0 0 0
ARDELYX INC Common Stock 039697107 13,680 1,057,257 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC Common Stock 042564203 1,963 4,177,577 SH   SOLE   0 0 0
ARROWHEAD PHARMACEUTICALS INC Common Stock 04280A100 6,228 847,458 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC Common Stock 045396108 5,606 777,669 SH   SOLE   0 0 0
ATRICURE INC Common Stock 04963C209 126 7,949 SH   SOLE   0 0 0
AUDENTES THERAPEUTICS INC Common Stock 05070R104 134 7,500 SH   SOLE   0 0 0
AVEO PHARMACEUTICALS INC Common Stock 053588109 2,766 3,108,808 SH   SOLE   0 0 0
AVEXIS INC Common Stock 05366U100 7,830 190,000 SH   SOLE   0 0 0
AVINGER INC Common Stock 053734109 5 1,062 SH   SOLE   0 0 0
BEIGENE LTD Depository Receipt 07725L102 4,069 132,057 SH   SOLE   0 0 0
BIO RAD LABORATORIES CLASS A Common Stock 090572207 1,638 10,000 SH   SOLE   0 0 0
BIOGEN INC Common Stock 09062X103 601 1,921 SH   SOLE   0 0 0
BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101 23 250 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP Common Stock 09627Y109 13,662 460,024 SH   SOLE   0 0 0
BOVIE MEDICAL CORP Common Stock 10211F100 253 48,544 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS Common Stock 10501E102 964 400,000 SH   SOLE   0 0 0
CAPITAL SENIOR LIVING CORP Common Stock 140475104 6,305 375,306 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC Common Stock 14070B101 13 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC Common Stock 14149Y108 497 6,398 SH   SOLE   0 0 0
CASCADIAN THERAPEUTICS INC Common Stock 14740B101 5,599 3,414,121 SH   SOLE   0 0 0
CELLECTIS ADR Depository Receipt 15117K103 4,323 179,506 SH   SOLE   0 0 0
CEMPRA INC Common Stock 15130J109 4,247 175,503 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY INC Common Stock 15870P307 625 372,597 SH   SOLE   0 0 0
CHARLES RIVER LABORATORIES Common Stock 159864107 457 5,482 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODUCTS INC Common Stock 16938C106 1,705 13,695 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC Common Stock 171757107 8,855 773,369 SH   SOLE   0 0 0
CLEARSIDE BIOMEDICAL INC COMMON Stock 185063104 11,013 634,801 SH   SOLE   0 0 0
CLOVIS ONCOLOGY INC Common Stock 189464100 6,183 171,500 SH   SOLE   0 0 0
COGENTIX MEDICAL INC Common Stock 19243A104 180 99,008 SH   SOLE   0 0 0
COLUCID PHARMACEUTICALS INC Common Stock 19716T101 21,060 552,030 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS HOLDINGS Common Stock 21833P103 18,339 2,701,023 SH   SOLE   0 0 0
CRYOLIFE INC Common Stock 228903100 2 123 SH   SOLE   0 0 0
CYNOSURE INC CLASS A Common Stock 232577205 92 1,800 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS, INC Preferred Stock 232996751 11,634 742,021 SH   SOLE   0 0 0
DBV TECHNOLOGIES SA-SPON ADR Depository Receipt 23306J101 20,464 563,268 SH   SOLE   0 0 0
DEPOMED INC Common Stock 249908104 13,370 535,000 SH   SOLE   0 0 0
DERMA SCIENCES INC Common Stock 249827502 14 2,970 SH   SOLE   0 0 0
DERMIRA INC Common Stock 24983L104 11,215 331,610 SH   SOLE   0 0 0
DEXCOM INC Common Stock 252131107 15,678 178,849 SH   SOLE   0 0 0
DIGIRAD CORP Common Stock 253827109 127 24,988 SH   SOLE   0 0 0
DYNAVAX TECHNOLOGIES CORP SHS PUT 12 12/16/2016 US Equity Option 268158201 3,120 6,000 SH Put SOLE   0 0 0
DYNAVAX TECHNOLOGIES CORP SHS PUT 11 12/16/2016 US Equity Option 268158201 1,780 4,000 SH Put SOLE   0 0 0
DYNAVAX TECHNOLOGIES CORP SHS PUT 10 12/16/2016 US Equity Option 268158201 2,280 6,000 SH Put SOLE   0 0 0
EAGLE PHARMACEUTICALS INC Common Stock 269796108 3 544,770 SH   SOLE   0 0 0
EIGER BIOPHARMACEUTICALS INC Common Stock 28249U105 1,739 129,920 SH   SOLE   0 0 0
ELI LILLY & CO CALL 90 01/20/2017 US Equity Option 532457108 250 1,000 SH Call SOLE   0 0 0
ENZO BIOCHEM INC Common Stock 294100102 342 67,113 SH   SOLE   0 0 0
EVOLENT HEALTH INC CLASS A Common Stock 30050B101 10,544 428,284 SH   SOLE   0 0 0
FERRARI NV Common Stock N3167Y103 322 6,200 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES NV Common Stock N31738102 397 62,000 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC Common Stock 33830X104 8,740 166,509 SH   SOLE   0 0 0
FLAMEL TECHNOLOGIES -SP ADR Depository Receipt 338488109 16,910 1,363,711 SH   SOLE   0 0 0
FLEX PHARMA INC Common Stock 33938A105 3 237 SH   SOLE   0 0 0
FOAMIX PHARMACEUTICALS LTD Common Stock M46135105 12,717 1,373,284 SH   SOLE   0 0 0
FORWARD PHARMA A/S-ADR Depository Receipt 34986J105 8,494 404,472 SH   SOLE   0 0 0
GENVEC INC Common Stock 37246C307 259 561,320 SH   SOLE   0 0 0
GLAUKOS CORP Common Stock 377322102 200 5,300 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS INC Common Stock 37890U108 53,802 2,334,168 SH   SOLE   0 0 0
HANGER INC Common Stock 41043F208 128 15,038 SH   SOLE   0 0 0
HCA HOLDINGS INC Common Stock 40412C101 469 6,202 SH   SOLE   0 0 0
HEALTHWAYS INC Common Stock 422245100 572 21,608 SH   SOLE   0 0 0
HILL ROM HOLDINGS INC Common Stock 431475102 593 9,563 SH   SOLE   0 0 0
HISTOGENCIS CORP Common Stock 43358V109 5,706 1,777,777 SH   SOLE   0 0 0
HUMANA INC CALL 190 04/21/2017 US Equity Option 444859102 526 400 SH Call SOLE   0 0 0
ICON INC Common Stock G4705A100 532 6,873 SH   SOLE   0 0 0
IGNYTA INC Common Stock 451731103 2,137 339,727 SH   SOLE   0 0 0
IMMUNE DESIGN CORP Common Stock 45252L103 589 77,725 SH   SOLE   0 0 0
IMMUNOMEDICS INC Common Stock 452907108 17 5,343 SH   SOLE   0 0 0
INC RESEARCH HOLDINGS INC CLASS A Common Stock 45329R109 563 12,636 SH   SOLE   0 0 0
INCYTE CORP Common Stock 45337C102 530 5,619 SH   SOLE   0 0 0
INNOCOLL HOLDINGS PLC Common Stock G4783X105 3,221 547,792 SH   SOLE   0 0 0
INOGEN INC Common Stock 45780L104 7 125 SH   SOLE   0 0 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105 250 14,673 SH   SOLE   0 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602 145 200 SH   SOLE   0 0 0
INVACARE CORP Common Stock 461203101 147 13,200 SH   SOLE   0 0 0
KADMON INC Common Stock 48283N106 16,218 2,209,657 SH   SOLE   0 0 0
KINDRED HEATHCARE INC Common Stock 494580103 432 42,301 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL COMPANY Common Stock 503459604 31,482 1,323,324 SH   SOLE   0 0 0
LABORATORY CORPORATION OF AMERICA HOLDINGS Common Stock 50540R409 549 3,990 SH   SOLE   0 0 0
LANNETT COMPANY INC Common Stock 516012101 709 26,670 SH   SOLE   0 0 0
LANTHEUS HOLDINGS INC Common Stock 516544103 445 53,763 SH   SOLE   0 0 0
LHC GROUP INC Common Stock 50187A107 175 4,745 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC Common Stock 53619R102 29,360 3,567,553 SH   SOLE   0 0 0
MAGELLAN HEALTH INC Common Stock 559079207 471 8,772 SH   SOLE   0 0 0
MALLINCKRODT PLC Common Stock G5785G107 314 4,500 SH   SOLE   0 0 0
MCKESSON CORP Common Stock 58155Q103 497 2,979 SH   SOLE   0 0 0
MEDGENICS INC Common Stock 58436Q203 1,635 293,460 SH   SOLE   0 0 0
MEDIDATA SOLUTIONS INC Common Stock 58471A105 160 2,865 SH   SOLE   0 0 0
MEDNAX INC Common Stock 58502B106 2 29 SH   SOLE   0 0 0
MERRIMACK PHARMACEUTICALS INC Common Stock 590328100 311 48,910 SH   SOLE   0 0 0
METTLER TOLEDO INTERNATIONAL Common Stock 592688105 174 415 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP Common Stock 552768103 2,275 329,733 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES INC Common Stock 603380106 11,440 810,537 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC Common Stock 60855R100 518 8,879 SH   SOLE   0 0 0
MYLAN NV Common Stock N59465109 3,610 94,711 SH   SOLE   0 0 0
MYOKARDIA INC Common Stock 62857M105 10,374 634,894 SH   SOLE   0 0 0
NANOSTRING TECHNOLOGIES INC Common Stock 63009R109 210 10,518 SH   SOLE   0 0 0
NEOS THERAPEUTICS INC Common Stock 64052L106 2,175 330,593 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES AND BIORESOURCES Common Stock 64077P108 7,155 6,750,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC Common Stock 64125C109 125,398 2,476,272 SH   SOLE   0 0 0
NEURODERM LTD Common Stock M74231107 4,883 264,114 SH   SOLE   0 0 0
NEVRO CORP Common Stock 64157F103 1,226 11,746 SH   SOLE   0 0 0
NIVALIS THERAPEUTICS INC Common Stock 65481J109 994 122,275 SH   SOLE   0 0 0
NUVASIVE INC Common Stock 670704105 173 2,589 SH   SOLE   0 0 0
NXSTAGE MEDICAL INC Common Stock 67072V103 41,726 1,669,703 SH   SOLE   0 0 0
ONCOBIOLOGICS INC Common Stock 68235M105 5,308 1,248,990 SH   SOLE   0 0 0
ONCOBIOLOGICS INC *W EXP 2/18/2017 68235M121 787 656,382 SH   SOLE   0 0 0
ONCOBIOLOGICS INC *W EXP 2/18/2017 68235M113 313 656,382 SH   SOLE   0 0 0
OPHTHOTECH CORP CALL 80 12/16/2016 US Equity Option 683745103 2,350 500,000 SH Call SOLE   0 0 0
OPHTHOTECH CORP CALL 75 12/16/2016 US Equity Option 683745103 390 100,000 SH Call SOLE   0 0 0
PEREGRINE PHARMACEUTICALS Common Stock 713661304 10 24,332 SH   SOLE   0 0 0
PERNIX THERAPEUTICS HLDINGS INC DBCV 4.25% 4/01/2021 71426VAK4 292 1,000,000 PRN   SOLE   0 0 0
PFENEX INC Common Stock 717071104 8,412 939,930 SH   SOLE   0 0 0
PHASERX INC Common Stock 71723F103 514 200,000 SH   SOLE   0 0 0
PHIBRO ANIMAL HEALTH CLASS A Common Stock 71742Q106 660 24,300 SH   SOLE   0 0 0
PROTEON THERAPEUTICS INC Common Stock 74371L109 2,510 269,005 SH   SOLE   0 0 0
PROTEOSTASIS THERAPEUTICS INC Common Stock 74373B109 5,372 344,550 SH   SOLE   0 0 0
PSIVIDA CORP Common Stock 74440J101 7,683 2,552,431 SH   SOLE   0 0 0
PSYCHEMEDICS CORP Common Stock 744375205 250 12,626 SH   SOLE   0 0 0
PUMA BIOTECHNOLOGY INC Common Stock 74587V107 492 7,344 SH   SOLE   0 0 0
QUINTILES IMS HOLDINGS INC Common Stock 74876Y101 414 5,103 SH   SOLE   0 0 0
QUOTIENT LTD Common Stock G73268107 20,893 2,671,794 SH   SOLE   0 0 0
RADIUS HEALTH INC Common Stock 750469207 16,957 313,502 SH   SOLE   0 0 0
REGENXBIO INC Common Stock 75901B107 17,964 1,282,286 SH   SOLE   0 0 0
RETROPHIN INC Common Stock 761299106 54,752 2,446,482 SH   SOLE   0 0 0
SANGAMO BIOSCIENCES INC Common Stock 800677106 1 272 SH   SOLE   0 0 0
SAREPTA THERAPEUTICS INC Common Stock 803607100 208,506 3,395,236 SH   SOLE   0 0 0
SCYNEXIS INC Common Stock 811292101 662 171,185 SH   SOLE   0 0 0
SELECTA BIOSCIENCES INC Common Stock 816212104 4,961 348,150 SH   SOLE   0 0 0
SEVION THERAPEUTICS INC Common Stock 81834Q104 10 59,220 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC Common Stock 85858C107 116 10,702 SH   SOLE   0 0 0
SUCAMPO PHARMACEUTICALS CLASS A Common Stock 864909106 506 41,096 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC Common Stock 868459108 6,048 244,550 SH   SOLE   0 0 0
SYNERGY PHARMACEUTICALS INC Common Stock 871639308 491 89,127 SH   SOLE   0 0 0
TELADOC INC Common Stock 87918A105 275 15,000 SH   SOLE   0 0 0
TENET HEALTHCARE CORP Common Stock 88033G407 367 16,200 SH   SOLE   0 0 0
TENGION INC Common Stock 88034G208 1 1,826,399 SH   SOLE   0 0 0
TESARO INC Common Stock 881569107 68,405 682,415 SH   SOLE   0 0 0
UNIQURE NV Common Stock N90064101 10,043 1,312,836 SH   SOLE   0 0 0
UNITED THERAPEUTICS INC Common Stock 91307C102 561 4,753 SH   SOLE   0 0 0
UNITEDHEALTH GROUP INC Common Stock 91324P102 452 3,231 SH   SOLE   0 0 0
UNIVERSAL HEALTH SERVICES CLASS B Common Stock 913903100 492 3,989 SH   SOLE   0 0 0
VBI VACCINES INC Common Stock 91822J103 10,490 3,058,433 SH   SOLE   0 0 0
VCA INC Common Stock 918194101 556 7,940 SH   SOLE   0 0 0
VERICEL CORP Common Stock 92346J108 1,526 544,996 SH   SOLE   0 0 0
VERSARTIS INC Common Stock 92529L102 49,351 4,028,685 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS INC Common Stock 92532F100 9,331 107,000 SH   SOLE   0 0 0
VOCERA COMMUNICATIONS INC Common Stock 92857F107 1,593 94,236 SH   SOLE   0 0 0
VWR CORP Common Stock 91843L103 529 18,657 SH   SOLE   0 0 0
WAVE LIFE SCIENCES LTD Common Stock Y95308105 22,191 683,448 SH   SOLE   0 0 0
WELLCARE HEALTHCARE PLANS INC Common Stock 94946T106 592 5,056 SH   SOLE   0 0 0
XENCOR INC Common Stock 98401F105 36,643 1,496,229 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC Common Stock 98420N105 6,179 762,800 SH   SOLE   0 0 0
ZOGENIX INC Common Stock 98978L204 212 18,541 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC Common Stock 98986X109 11,339 868,897 SH   SOLE   0 0 0