The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 21VIANET GROUP INC | SPONSORED ADR | 90138A103 | 85,685 | 10,778,004 | SH | DFND | 6,20 | 10,778,004 | 0 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 22,029 | 1,337,500 | SH | DFND | 9,19,22 | 1,337,500 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 150,311 | 1,226,630 | SH | DFND | 3,9,13 | 1,226,630 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 4,185,324 | 39,562,566 | SH | DFND | 1,5,15,16,18 | 39,562,566 | 0 | 0 | |
| AMYRIS INC | COM | 03236M101 | 40,363 | 69,592,216 | SH | DFND | 3,9,13 | 69,592,216 | 0 | 0 | |
| AMYRIS INC | NOTE 6.500% 5/1 | 03236MAC5 | 6,800 | 10,000,000 | PRN | DFND | 3,9,13 | 10,000,000 | 0 | 0 | |
| B/E AEROSPACE INC | COM | 073302101 | 109,856 | 2,126,523 | SH | DFND | 1,15,18 | 2,126,523 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 11,708 | 380,000 | SH | DFND | 9,19,22 | 380,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 321,295 | 3,472,712 | SH | DFND | 3,9,13,19,22 | 3,472,712 | 0 | 0 | |
| CTRIP COM INTL LTD | AMERICAN DEP SHS | 22943F100 | 16,307 | 350,159 | SH | DFND | 5,15,18 | 350,159 | 0 | 0 | |
| DELL TECHNOLOGIES INC | COM CL V | 24703L103 | 75,341 | 1,576,167 | SH | DFND | 5,14,15,18 | 1,576,167 | 0 | 0 | |
| EROS INTL PLC | SHS NEW | G3788M114 | 42,211 | 2,755,310 | SH | DFND | 5,14,15,18 | 2,775,310 | 0 | 0 | |
| GILEAD SCIENCES INC | COM | 375558103 | 1,094,270 | 13,830,516 | SH | DFND | 9,19,22 | 13,830,516 | 0 | 0 | |
| ICICI BK LTD | ADR | 45104G104 | 19,076 | 2,553,625 | SH | DFND | 3,9 | 2,553,625 | 0 | 0 | |
| IHS MARKIT LTD | SHS | G47567105 | 795,058 | 21,173,310 | SH | DFND | 6,20 | 21,173,310 | 0 | 0 | |
| ILLUMINA INC | COM | 452327109 | 50,367 | 277,261 | SH | DFND | 1,15,18 | 277,261 | 0 | 0 | |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | 13,455 | 790,527 | SH | DFND | 7,9,18,19 | 790,527 | 0 | 0 | |
| JD COM INC | SPON ADR CL A | 47215P106 | 190,628 | 7,306,572 | SH | DFND | 7,18 | 7,306,572 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 27,482 | 915,750 | SH | DFND | 9,19,22 | 915,750 | 0 | 0 | |
| LEVEL 3 COMMUNICATIONS INC | COM NEW | 52729N308 | 3,016,169 | 65,031,667 | SH | DFND | 65,031,667 | 0 | 0 | ||
| MARIN SOFTWARE INC | COM | 56804T106 | 6,371 | 2,528,205 | SH | DFND | 5,15,16,18 | 2,528,205 | 0 | 0 | |
| PAYPAL HLDGS INC | COM | 70450Y103 | 220,745 | 5,387,963 | SH | DFND | 5,9,11,15,17,18 | 5,387,963 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 149,513 | 6,583,568 | SH | DFND | 3,9,13,19,22 | 6,583,568 | 0 | 0 | |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 50,796 | 126,351 | SH | DFND | 9,19,22 | 126,351 | 0 | 0 | |
| ROYAL DUTCH SHELL PLC | SPON ADR B | 780259107 | 21,583 | 408,543 | SH | DFND | 7,18 | 408,543 | 0 | 0 | |
| SYNCHRONY FINL | COM | 87165B103 | 183,717 | 6,561,333 | SH | DFND | 1,15,18 | 6,561,333 | 0 | 0 | |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 461,165 | 2,899,315 | SH | DFND | 3,9,13 | 2,899,315 | 0 | 0 | |
| TUNIU CORP | SPONSORED ADS CL | 89977P106 | 82,928 | 8,194,444 | SH | DFND | 6,20 | 8,194,444 | 0 | 0 | |
| TURQUOISE HILL RES LTD | COM | 900435108 | 217,445 | 73,213,884 | SH | DFND | 4,20,21 | 73,213,884 | 0 | 0 | |
| UNIVAR INC | COM | 91336L107 | 494,711 | 22,641,230 | SH | DFND | 4,20,21 | 22,641,230 | 0 | 0 | |
| VIRTU FINL INC | CL A | 928254101 | 184,396 | 12,317,682 | SH | DFND | 8,10 | 12,317,682 | 0 | 0 | |