The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4,004 37,848 SH   SOLE   37,848 0 0
COSTAR GROUP INC COM 22160N109 54,227 250,437 SH   SOLE   250,437 0 0
CURRENCYSHS JAPANESE YEN TR JAPANESE YEN 23130A102 3,018 31,699 SH   DFND   31,699 0 0
EDITAS MEDICINE INC COM 28106W103 631 46,775 SH   SOLE   46,775 0 0
ISHARES TR 20 YR TR BD ETF 464287432 662 4,832 SH   SOLE   4,832 0 0
ISHARES TR IBOXX HI YD ETF 464288513 2,836 32,796 SH   DFND   32,796 0 0
ISHARES TR JP MOR EM MK ETF 464288281 2,565 22,066 SH   DFND   22,066 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 2,696 9,315 SH   DFND   9,315 0 0
ISHARES TR 20 YR TR BD ETF 464287432 3,496 25,515 SH   DFND   25,515 0 0
ISHARES TR CALL 464287900 5,671 50,830 SH Call DFND   50,830 0 0
ISHARES TR PUT 464287954 1,479 39,505 SH Put DFND   39,505 0 0
ISHARES TR CALL 464287904 1,000 26,710 SH Call DFND   26,710 0 0
ISHARES TR PUT 464287950 5,121 45,900 SH Put DFND   45,900 0 0
ISHARES TR PUT 464287904 986 25,950 SH Put DFND   25,950 0 0
ISHARES TR PUT 464287955 4,641 78,480 SH Put DFND   78,480 0 0
KITE PHARMA INC COM 49803L109 131,723 2,358,084 SH   SOLE   2,358,084 0 0
LPL FINL HLDGS INC COM 50212V100 6,139 206,647 SH   SOLE   206,647 0 0
MIMEDX GROUP INC COM 602496101 9,270 1,080,365 SH   SOLE   1,080,365 0 0
NANTHEALTH INC COM 630104107 1,547 117,623 SH   SOLE   117,623 0 0
NANTHEALTH INC COM 630104107 1,553 118,129 SH   DFND   118,129 0 0
NANTKWEST INC COM 63016Q102 34,897 4,485,495 SH   SOLE   4,485,495 0 0
POWERSHARES DB CMDTY IDX TRA UNIT BEN INT 73935S105 919 61,220 SH   DFND   61,220 0 0
POWERSHARES QQQ TRUST UNIT SER 1 73935A104 1,916 16,137 SH   DFND   16,137 0 0
POWERSHARES QQQ TRUST CALL 73935A904 17,915 150,905 SH Call DFND   150,905 0 0
RYANAIR HLDGS PLC SPONSORED ADR NE 783513203 86,415 5,654,679 SH   SOLE   5,654,679 0 0
SPDR S&P 500 ETF TR PUT 78462F953 6,781 31,350 SH Put DFND   31,350 0 0
SPDR S&P 500 ETF TR CALL 78462F903 2,563 11,850 SH Call DFND   11,850 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 20,714 2,676,193 SH   SOLE   2,676,193 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 957 123,597 SH   DFND   123,597 0 0
UNITED STATES NATL GAS FUND UNIT PAR $0.001 912318201 1,010 120,821 SH   DFND   120,821 0 0
WISDOMTREE TR JAPN HEDGE EQT 97717W851 858 20,000 SH   SOLE   20,000 0 0