The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 3,774 100,000 SH Put DFND 1,2,3 0 100,000 0
ALCOBRA LTD SHS M2239P109 980 396,800 SH   DFND 1,2,3 0 396,800 0
ALLERGAN PLC PFD CONV SER A G0177J116 10,269 12,500 PRN   DFND 1,2,3 0 12,500 0
ALPHABET INC CAP STK CL A 02079K305 38,227 47,543 SH   DFND 1,2,3 0 47,543 0
AMAG PHARMACEUTICALS INC COM 00163U106 6,680 272,526 SH   DFND 1,2,3 0 272,526 0
AMAZON COM INC COM 023135106 78,839 94,157 SH   DFND 1,2,3 0 94,157 0
AMERICAN AIRLS GROUP INC COM 02376R102 14,641 838,238 SH   DFND 1,2,3 0 838,238 0
ANTARES PHARMA INC COM 036642106 2,733 1,626,738 SH   DFND 1,2,3 0 1,626,738 0
APACHE CORP COM 037411105 48,625 761,308 SH   DFND 1,2,3 0 761,308 0
ARIAD PHARMACEUTICALS INC COM 04033A100 1,369 100,000 SH Put DFND 1,2,3 0 100,000 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,699 51,700 SH Call DFND 1,2,3 0 51,700 0
AXOVANT SCIENCES LTD COM G0750W104 1,739 124,188 SH   DFND 1,2,3 0 124,188 0
BLACKSTONE MTG TR INC COM CL A 09257W100 9,542 324,000 SH   DFND 1,2,3 0 324,000 0
CALLON PETE CO DEL COM 13123X102 20,099 1,280,198 SH   DFND 1,2,3 0 1,280,198 0
CDK GLOBAL INC COM 12508E101 41,364 721,134 SH   DFND 1,2,3 0 721,134 0
CHUBB LIMITED COM H1467J104 24,339 193,705 SH   DFND 1,2,3 0 193,705 0
CITIGROUP INC COM NEW 172967424 32,812 694,733 SH   DFND 1,2,3 0 694,733 0
CITIGROUP INC COM NEW 172967424 23,667 501,100 SH Call DFND 1,2,3 0 501,100 0
COCA COLA EUROPEAN PARTNERS SHS G25839104 7,134 178,808 SH   DFND 1,2,3 0 178,808 0
COLUCID PHARMACEUTICALS INC COM 19716T101 5,912 154,963 SH   DFND 1,2,3 0 154,963 0
COMERICA INC COM 200340107 19,904 420,623 SH   DFND 1,2,3 0 420,623 0
CONSTELLATION BRANDS INC CL A 21036P108 5,126 30,790 SH   DFND 1,2,3 0 30,790 0
CSX CORP COM 126408103 10,166 333,320 SH   DFND 1,2,3 0 333,320 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,860 958,822 SH   DFND 1,2,3 0 958,822 0
DANAHER CORP DEL COM 235851102 20,450 260,871 SH   DFND 1,2,3 0 260,871 0
DELL TECHNOLOGIES INC COM CL V 24703L103 22,640 473,643 SH   DFND 1,2,3 0 473,643 0
DEPOMED INC COM 249908104 2,497 100,000 SH Put DFND 1,2,3 0 100,000 0
DEVON ENERGY CORP NEW COM 25179M103 21,950 497,625 SH   DFND 1,2,3 0 497,625 0
DIPEXIUM PHARMACEUTICALS INC COM 25456J104 13,720 946,223 SH   DFND 1,2,3 0 946,223 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 5,996 571,555 SH   DFND 1,2,3 0 571,555 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 12,644 1,205,300 SH Call DFND 1,2,3 0 1,205,300 0
EAGLE MATERIALS INC COM 26969P108 14,942 193,305 SH   DFND 1,2,3 0 193,305 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 3,260 103,400 SH Call DFND 1,2,3 0 103,400 0
ENDURANCE SPECIALTY HLDGS LT SHS G30397106 10,583 161,700 SH   DFND 1,2,3 0 161,700 0
ENTELLUS MED INC COM 29363K105 5,071 228,647 SH   DFND 1,2,3 0 228,647 0
EXELIXIS INC COM 30161Q104 1,685 131,757 SH   DFND 1,2,3 0 131,757 0
EXELIXIS INC COM 30161Q104 14,078 1,100,700 SH Call DFND 1,2,3 0 1,100,700 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 14,134 200,400 SH Put DFND 1,2,3 0 200,400 0
FATE THERAPEUTICS INC COM 31189P102 8,823 2,827,889 SH   DFND 1,2,3 0 2,827,889 0
FLEXION THERAPEUTICS INC COM 33938J106 20,861 1,067,621 SH   DFND 1,2,3 0 1,067,621 0
FLOWSERVE CORP COM 34354P105 12,026 249,300 SH   DFND 1,2,3 0 249,300 0
FORTIVE CORP COM 34959J108 26,027 511,333 SH   DFND 1,2,3 0 511,333 0
GAMING & LEISURE PPTYS INC COM 36467J108 8,126 242,925 SH   DFND 1,2,3 0 242,925 0
GENERAL MLS INC COM 370334104 19,164 300,000 SH Call DFND 1,2,3 0 300,000 0
GILEAD SCIENCES INC COM 375558103 4,642 58,668 SH   DFND 1,2,3 0 58,668 0
GREAT ELM CAP GROUP INC COM 39036P100 2,556 545,020 SH   DFND 1,2,3 0 545,020 0
GW PHARMACEUTICALS PLC ADS 36197T103 13,286 100,100 SH Put DFND 1,2,3 0 100,100 0
HARTFORD FINL SVCS GROUP INC COM 416515104 1,261 29,444 SH   DFND 1,2,3 0 29,444 0
HCA HOLDINGS INC COM 40412C101 3,063 40,496 SH   DFND 1,2,3 0 40,496 0
HERBALIFE LTD COM USD SHS G4412G101 39,515 637,449 SH   DFND 1,2,3 0 637,449 0
HERON THERAPEUTICS INC COM 427746102 46,452 2,695,997 SH   DFND 1,2,3 0 2,695,997 0
HOPE BANCORP INC COM 43940T109 5,495 316,339 SH   DFND 1,2,3 0 316,339 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 40,850 42,250,000 PRN   DFND 1,2,3 0 42,250,000 0
HORIZON PHARMA PLC SHS G4617B105 123,590 6,816,903 SH   DFND 1,2,3 0 6,816,903 0
HORIZON PHARMA PLC SHS G4617B105 66,187 3,650,700 SH Call DFND 1,2,3 0 3,650,700 0
INFOSYS LTD SPONSORED ADR 456788108 2,179 138,100 SH Put DFND 1,2,3 0 138,100 0
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 7,670 5,700,000 PRN   DFND 1,2,3 0 5,700,000 0
INTL PAPER CO COM 460146103 46,724 973,831 SH   DFND 1,2,3 0 973,831 0
INVUITY INC COM NEW 46187J205 6,368 464,150 SH   DFND 1,2,3 0 464,150 0
JAGUAR ANIMAL HEALTH INC COM 47008L106 1,291 1,008,642 SH   DFND 1,2,3 0 1,008,642 0
KADMON HLDGS INC COM 48283N106 379 54,333 SH   DFND 1,2,3 0 54,333 0
KELLOGG CO COM 487836108 7,747 100,000 SH Call DFND 1,2,3 0 100,000 0
KEMPHARM INC COM 488445107 1,167 259,967 SH   DFND 1,2,3 0 259,967 0
KINSALE CAP GROUP INC COM 49714P108 1,650 75,000 SH   DFND 1,2,3 0 75,000 0
KLX INC COM 482539103 5,323 151,208 SH   DFND 1,2,3 0 151,208 0
KROGER CO COM 501044101 2,944 99,200 SH   DFND 1,2,3 0 99,200 0
LENNAR CORP CL A 526057104 21,997 519,532 SH   DFND 1,2,3 0 519,532 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 14,631 809,666 SH   DFND 1,2,3 0 809,666 0
LIBERTY MEDIA CORP DEB 4.000%11/1 530715AG6 8,645 14,000,000 PRN   DFND 1,2,3 0 14,000,000 0
LILLY ELI & CO COM 532457108 8,090 100,800 SH Call DFND 1,2,3 0 100,800 0
LOCKHEED MARTIN CORP COM 539830109 11,522 48,066 SH   DFND 1,2,3 0 48,066 0
LOWES COS INC COM 548661107 16,581 229,616 SH   DFND 1,2,3 0 229,616 0
LUMENTUM HLDGS INC COM 55024U109 15,415 369,052 SH   DFND 1,2,3 0 369,052 0
MEDIWOUND LTD ORD SHS M68830104 651 84,590 SH   DFND 1,2,3 0 84,590 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 10,809 249,913 SH   DFND 1,2,3 0 249,913 0
MOLSON COORS BREWING CO CL A 60871R100 9,824 89,473 SH   DFND 1,2,3 0 89,473 0
MONDELEZ INTL INC CL A 609207105 8,780 200,000 SH Call DFND 1,2,3 0 200,000 0
MONSTER BEVERAGE CORP NEW COM 61174X109 6,410 43,659 SH   DFND 1,2,3 0 43,659 0
NEWELL BRANDS INC COM 651229106 127,602 2,423,128 SH   DFND 1,2,3 0 2,423,128 0
NEXSTAR BROADCASTING GROUP I CL A 65336K103 47,032 814,973 SH   DFND 1,2,3 0 814,973 0
NIVALIS THERAPEUTICS INC COM 65481J109 4,404 541,700 SH   DFND 1,2,3 0 541,700 0
NOBLE ENERGY INC COM 655044105 42,988 1,202,805 SH   DFND 1,2,3 0 1,202,805 0
NOMAD HLDGS LTD USD ORD SHS G6564A105 15,115 1,278,750 SH   DFND 1,2,3 0 1,278,750 0
NOVAN INC COM 66988N106 3,994 197,940 SH   DFND 1,2,3 0 197,940 0
OPHTHOTECH CORP COM 683745103 1,527 33,100 SH Call DFND 1,2,3 0 33,100 0
OTONOMY INC COM 68906L105 9,005 495,074 SH   DFND 1,2,3 0 495,074 0
PBF ENERGY INC CL A 69318G106 12,038 531,700 SH   DFND 1,2,3 0 531,700 0
PEPSICO INC COM 713448108 6,517 59,920 SH   DFND 1,2,3 0 59,920 0
PINNACLE FOODS INC DEL COM 72348P104 30,766 613,226 SH   DFND 1,2,3 0 613,226 0
PROCTER AND GAMBLE CO COM 742718109 8,076 89,985 SH   DFND 1,2,3 0 89,985 0
RECRO PHARMA INC COM 75629F109 1,017 115,000 SH   DFND 1,2,3 0 115,000 0
RETROPHIN INC COM 761299106 8,506 380,075 SH   DFND 1,2,3 0 380,075 0
SAGE THERAPEUTICS INC COM 78667J108 23,347 506,990 SH   DFND 1,2,3 0 506,990 0
SAREPTA THERAPEUTICS INC COM 803607100 3,071 50,000 SH Put DFND 1,2,3 0 50,000 0
SHERWIN WILLIAMS CO COM 824348106 13,800 49,880 SH   DFND 1,2,3 0 49,880 0
SINCLAIR BROADCAST GROUP INC CL A 829226109 9,322 322,779 SH   DFND 1,2,3 0 322,779 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 381,402 1,763,300 SH Put DFND 1,2,3 0 1,763,300 0
SPDR SERIES TRUST S&P BK ETF 78464A797 33,453 1,002,200 SH Call DFND 1,2,3 0 1,002,200 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 13,278 200,300 SH Put DFND 1,2,3 0 200,300 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 9,028 1,638,410 SH   DFND 1,2,3 0 1,638,410 0
T MOBILE US INC COM 872590104 14,600 312,500 SH   DFND 1,2,3 0 312,500 0
TARGA RES CORP COM 87612G101 2,966 60,400 SH   DFND 1,2,3 0 60,400 0
TEMPUR SEALY INTL INC COM 88023U101 14,452 254,700 SH   DFND 1,2,3 0 254,700 0
TESARO INC COM 881569107 6,877 68,608 SH   DFND 1,2,3 0 68,608 0
TESARO INC COM 881569107 5,022 50,100 SH Call DFND 1,2,3 0 50,100 0
TONIX PHARMACEUTICALS HLDG C COM NEW 890260201 856 1,227,832 SH   DFND 1,2,3 0 1,227,832 0
TRINA SOLAR LIMITED DBCV 3.500% 6/1 89628EAC8 4,869 5,000,000 PRN   DFND 1,2,3 0 5,000,000 0
TYSON FOODS INC CL A 902494103 16,674 223,309 SH   DFND 1,2,3 0 223,309 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 7,382 300,700 SH Call DFND 1,2,3 0 300,700 0
VANDA PHARMACEUTICALS INC COM 921659108 6,697 402,456 SH   DFND 1,2,3 0 402,456 0
VANDA PHARMACEUTICALS INC COM 921659108 7,525 452,200 SH Call DFND 1,2,3 0 452,200 0
VERSARTIS INC COM 92529L102 5,893 481,056 SH   DFND 1,2,3 0 481,056 0
VIRTU FINL INC CL A 928254101 4,317 288,408 SH   DFND 1,2,3 0 288,408 0
WESTROCK CO COM 96145D105 8,831 182,155 SH   DFND 1,2,3 0 182,155 0
WPX ENERGY INC COM 98212B103 31,125 2,359,722 SH   DFND 1,2,3 0 2,359,722 0
ZELTIQ AESTHETICS INC COM 98933Q108 3,922 100,000 SH Put DFND 1,2,3 0 100,000 0