The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC COM 00484M106 49,485 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
AFFYMETRIX INC COM 00826T108 12,876 2,900,000 SH   DFND 1,2,3,4,5 2,900,000 0 0
AGENUS INC COM NEW 00847G705 1,554 410,130 SH   DFND 1,2,3,4,5 410,130 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 2,900 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 2,900 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 8,940 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AMGEN INC COM 031162100 17,266 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
AMGEN INC COM 031162100 4,933 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
APPLE INC COM 037833100 19,827 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
APPLE INC COM 037833100 43,618 110,000 SH Call DFND 1,2,3,4,5 110,000 0 0
APPLE INC COM 037833100 11,896 30,000 SH Call DFND 1,2,3,4,5 30,000 0 0
ARCOS DORADOS HOLDINGS INC SHS CLASS -A G0457F107 9,344 800,000 SH   DFND 1,2,3,4,5 800,000 0 0
ARCOS DORADOS HOLDINGS INC SHS CLASS -A G0457F107 4,672 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 13,620 3,000,000 SH   DFND 1,2,3,4,5 3,000,000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 43,859 2,637,200 SH   DFND 1,2,3,4,5 2,637,200 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 12,650 2,750,000 SH   DFND 1,2,3,4,5 2,750,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 1,380 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 2,300 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
BANK OF AMERICA CORPORATION COM 060505104 6,430 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
BANK OF AMERICA CORPORATION COM 060505104 12,860 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
BIODEL INC COM NEW 09064M204 1,215 290,740 SH   DFND 1,2,3,4,5 290,740 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 19,509 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 11,148 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BRF S A SPONSORED ADR 10552T107 10,855 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CHEMOCENTRYX INC COM 16383L106 3,889 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
CAPITAL ONE FINL CORP COM 14040H105 12,562 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
CEMENTOS PACASMAYO S A A SPON ADR REP 5 15126Q109 5,092 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
CERES INC COM 156773103 13,121 4,192,167 SH   DFND 1,2,3,4 4,192,167 0 0
CIT GROUP INC COM NEW 125581801 4,663 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CITIGROUP INC COM NEW 172967424 4,797 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CITIGROUP INC COM NEW 172967424 4,797 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CITIGROUP INC COM NEW 172967424 4,797 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
DOLLAR GEN CORP NEW COM 256677105 5,043 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
EMERSON ELEC CO COM 291011104 10,908 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 12,348 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FACEBOOK INC CL A 30303M102 6,220 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
FACEBOOK INC CL A 30303M102 4,976 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FIRST SOLAR INC COM 336433107 4,481 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
FLUIDIGM CORP DEL COM 34385P108 5,463 312,899 SH   DFND 1,2,3,4,6 312,899 0 0
FORD MTR CO DEL COM PAR $0.01 345370860 4,641 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
FORD MTR CO DEL COM PAR $0.01 345370860 4,641 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
FOREST LABS INC COM 345838106 12,300 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
FREEPORT-MCMORAN COPPER & GO COM 35671D857 5,522 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FURIEX PHARMACEUTICALS INC COM 36106P101 31,155 914,442 SH   DFND 1,2,3,4,5 914,442 0 0
GENERAL ELECTRIC CO COM 369604103 11,595 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
GENERAL ELECTRIC CO COM 369604103 20,871 900,000 SH Call DFND 1,2,3,4,5 900,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 22,688 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
HARTFORD FINL SVCS GROUP INC COM 416515104 10,822 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
HARTFORD FINL SVCS GROUP INC COM 416515104 4,638 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
IMMUNOGEN INC COM 45253H101 28,203 1,700,000 SH   DFND 1,2,3,4,5 1,700,000 0 0
IMMUNOGEN INC COM 45253H101 4,977 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,154 216,879 SH   DFND 1,2,3,4,6 216,879 0 0
ISHARES TR MSCI EMERG MKT 464287234 7,700 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ISHARES INC MSCI MEXICO CAP 464286822 9,787 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ISHARES INC MSCI MEXICO CAP 464286822 9,787 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
ISHARES INC MSCI MEXICO CAP 464286822 13,050 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ISHARES INC MSCI BRAZIL CAPP 464286400 87,720 2,000,000 SH Call DFND 1,2,3,4,5 2,000,000 0 0
ISHARES INC MSCI JAPAN 464286848 5,610 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ISHARES INC MSCI JAPAN 464286848 22,440 2,000,000 SH Call DFND 1,2,3,4,5 2,000,000 0 0
ITAU UNIBANCO HLDG SA SPON ADR REP PFD 465562106 5,168 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
ITAU UNIBANCO HLDG SA SPON ADR REP PFD 465562106 7,106 550,000 SH Call DFND 1,2,3,4,5 550,000 0 0
JPMORGAN CHASE & CO COM 46625H100 5,279 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
JPMORGAN CHASE & CO COM 46625H100 21,116 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
JPMORGAN CHASE & CO COM 46625H100 10,558 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 12,051 5,553,292 SH   DFND 1,2,3,4,5 5,553,292 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 537,767 247,818,843 SH   DFND 1,2,3,4,6 99,999,999 0 0
LILLY ELI & CO COM 532457108 9,824 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
LILLY ELI & CO COM 532457108 19,648 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
MARKET VECTORS ETF TR GOLD MINER ETF 57060U100 4,898 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MEAD JOHNSON NUTRITION CO COM 582839106 15,846 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MERCK & CO INC NEW COM 58933Y105 23,225 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
MERCK & CO INC NEW COM 58933Y105 13,935 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
MERITOR INC COM 59001K100 7,050 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
METLIFE INC COM 59156R108 18,304 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
METLIFE INC COM 59156R108 6,864 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
MGIC INVT CORP WIS COM 552848103 4,856 800,000 SH   DFND 1,2,3,4,5 800,000 0 0
MICHAEL KORS HLDGS LTD SHS G60754101 6,202 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MICHAEL KORS HLDGS LTD SHS G60754101 6,202 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
MICROVISION INC DEL *W EXP 07/23/201 594960163 11 360,515 SH   DFND 1,2,3,4,5 360,515 0 0
NEKTAR THERAPEUTICS COM 640268108 28,875 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,110 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,532 1,200,000 SH Call DFND 1,2,3,4,5 1,200,000 0 0
OCWEN FINL CORP COM NEW 675746309 14,427 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
OCWEN FINL CORP COM NEW 675746309 10,305 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
OCWEN FINL CORP COM NEW 675746309 4,122 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
ONYX PHARMACEUTICALS INC COM 683399109 26,046 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ONYX PHARMACEUTICALS INC COM 683399109 17,364 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ONYX PHARMACEUTICALS INC COM 683399109 8,682 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
PLY GEM HLDGS INC COM 72941W100 3,009 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
QUALCOMM INC COM 747525103 48,872 800,000 SH Call DFND 1,2,3,4,5 800,000 0 0
QUINTILES TRANSNATIO HLDGS I COM 74876Y101 9,576 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
ROCKWOOD HLDGS INC COM 774415103 6,403 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SCHLUMBERGER LTD COM 806857108 5,375 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
SMART TECHNOLOGIES INC CL A SUB VTG S 83172R108 1,494 1,098,369 SH   DFND 1,2,3,4,5 1,098,369 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 96,252 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 27,440 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 10,760 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
VALERO ENERGY CORP NEW COM 91913Y100 6,954 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
VIVUS INC COM 928551100 2,516 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 1,322,458 28,749,089 SH   DFND 1,2,3,4 28,749,089 0 0
WELLS FARGO & CO NEW COM 949746101 8,254 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
XOMA CORP DEL COM 98419J107 9,075 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
YUM BRANDS INC COM 988498101 13,868 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ZOETIS INC CL A 98978V103 6,178 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0