The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC COM 00484M106 37,455 1,095,170 SH   DFND 1,2,3,4,5 1,095,170 0 0
AFFYMETRIX INC COM 00826T108 7,434 1,200,000 SH   DFND 1,2,3,4,5 1,200,000 0 0
AGENUS INC COM NEW 00847G705 1,136 410,130 SH   DFND 1,2,3,4,5 410,130 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 6,320 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,957 70,000 SH   DFND 1,2,3,4,5 70,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 4,863 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
AMGEN INC COM 031162100 16,789 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
AMGEN INC COM 031162100 22,384 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
APPLE INC COM 037833100 83,431 175,000 SH Call DFND 1,2,3,4,5 175,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 18,660 3,000,000 SH   DFND 1,2,3,4,5 3,000,000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 47,997 2,637,200 SH   DFND 1,2,3,4,5 2,637,200 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 13,113 3,100,000 SH   DFND 1,2,3,4,5 3,100,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 1,269 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
BANK OF AMERICA CORPORATION COM 060505104 24,150 1,750,000 SH Call DFND 1,2,3,4,5 1,750,000 0 0
BIODEL INC COM NEW 09064M204 916 290,740 SH   DFND 1,2,3,4,5 290,740 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,043 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 14,434 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BLUEBIRD BIO INC COM 09609G100 4,044 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
CHEMOCENTRYX INC COM 16383L106 1,529 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
CEMENTOS PACASMAYO S A A SPON ADR REP 5 15126Q109 4,441 379,609 SH   DFND 1,2,3,4,5 379,609 0 0
CERES INC COM 156773103 6,246 4,192,167 SH   DFND 1,2,3,4 4,192,167 0 0
CIT GROUP INC COM NEW 125581801 4,877 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CITIGROUP INC COM NEW 172967424 19,404 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
DOLLAR GEN CORP NEW COM 256677105 5,646 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
ENSCO PLC SHS CLASS A G3157S106 10,750 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 12,360 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FLUIDIGM CORP DEL COM 34385P108 3,701 168,706 SH   DFND 1,2,3,4,6 168,706 0 0
FORD MTR CO DEL COM PAR $0.01 345370860 10,122 600,000 SH   DFND 1,2,3,4,5 600,000 0 0
FORD MTR CO DEL COM PAR $0.01 345370860 18,557 1,100,000 SH Call DFND 1,2,3,4,5 1,100,000 0 0
FREEPORT-MCMORAN COPPER & GO COM 35671D857 6,616 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FURIEX PHARMACEUTICALS INC COM 36106P101 42,717 971,051 SH   DFND 1,2,3,4,5 971,051 0 0
GENERAL ELECTRIC CO COM 369604103 90,782 3,800,000 SH Call DFND 1,2,3,4,5 3,800,000 0 0
GENERAL MTRS CO COM 37045V100 10,791 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 6,328 40,000 SH   DFND 1,2,3,4,5 40,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 11,866 75,000 SH Call DFND 1,2,3,4,5 75,000 0 0
HARTFORD FINL SVCS GROUP INC COM 416515104 15,560 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
IMMUNOGEN INC COM 45253H101 28,083 1,650,000 SH   DFND 1,2,3,4,5 1,650,000 0 0
IMMUNOGEN INC COM 45253H101 5,106 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,568 216,879 SH   DFND 1,2,3,4,6 216,879 0 0
ISHARES INC MSCI MEXICO CAP ETF 464286822 9,584 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
ISHARES INC US HOME CONS ETF 464288752 11,170 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
JPMORGAN CHASE & CO COM 46625H100 35,917 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
LEGGETT & PLATT INC COM 524660107 3,015 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
LENNAR CORP CL A 526057104 1,770 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 13,217 5,553,292 SH   DFND 1,2,3,4,5 5,553,292 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 589,809 247,818,843 SH   DFND 1,2,3,4,6 247,818,843 0 0
LILLY ELI & CO COM 532457108 30,198 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
MACYS INC COM 55616P104 23,799 550,000 SH Call DFND 1,2,3,4,5 550,000 0 0
MARKET VECTORS ETF TR GOLD MINER ETF 57060U100 5,004 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MASCO CORP COM 574599106 5,320 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
MEAD JOHNSON NUTRITION CO COM 582839106 18,565 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
MERCK & CO INC NEW COM 58933Y105 23,805 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
MERITOR INC COM 59001K100 5,896 750,100 SH   DFND 1,2,3,4,5 750,100 0 0
MERITOR INC COM 59001K100 1,965 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
MGIC INVT CORP WIS COM 552848103 5,460 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
MICHAEL KORS HLDGS LTD SHS G60754101 7,452 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MONDELEZ INTL INC CL A 609207105 6,284 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MORGAN STANLEY COM NEW 617446448 2,695 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
NEKTAR THERAPEUTICS COM 640268108 24,024 2,300,000 SH   DFND 1,2,3,4,5 2,300,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,320 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,784 1,200,000 SH Call DFND 1,2,3,4,5 1,200,000 0 0
OCWEN FINL CORP COM NEW 675746309 25,097 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
PEPSICO INC COM 713448108 23,850 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
PLY GEM HLDGS INC COM 72941W100 3,554 254,226 SH   DFND 1,2,3,4,5 254,226 0 0
PULTE GROUP INC COM 745867101 4,125 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
QUALCOMM INC COM 747525103 3,366 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
QUALCOMM INC COM 747525103 47,124 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
REALOGY HLDGS CORP COM 75605Y106 8,604 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
REALOGY HLDGS CORP COM 75605Y106 15,057 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
SMART TECHNOLOGIES INC CL A SUB VTG S 83172R108 1,546 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 4,680 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 252,015 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
SUNEDISON INC COM 86732Y109 1,993 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
TEREX CORP NEW COM 880779103 9,240 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 26,446 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
UNITED CONTL HLDGS INC COM 910047109 7,678 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 1,074,353 28,749,089 SH   DFND 1,2,3,4 28,749,089 0 0
WELLS FARGO & CO NEW COM 949746101 41,320 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
XOMA CORP DEL COM 98419J107 11,225 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
YUM BRANDS INC COM 988498101 28,556 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
ZOETIS INC CL A 98978V103 9,336 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0