The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC COM 00484M106 20,440 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
AGENUS INC COM NEW 00847G705 1,083 410,130 SH   DFND 1,2,3,4,5 410,130 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,635 110,000 SH   DFND 1,2,3,4,5 110,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,038 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
AMBIT BIOSCIENCES CORP COM 02318X100 2,410 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 30,630 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
AMARIN CORP PLC SPON ADR NEW 023111206 1,970 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
AMGEN INC COM 031162100 17,112 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
AMGEN INC COM 031162100 11,408 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
APPLE INC COM 037833100 56,102 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 15,030 3,000,000 SH   DFND 1,2,3,4,5 3,000,000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 31,095 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 24,876 1,200,000 SH Call DFND 1,2,3,4,5 1,200,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 6,720 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 3,696 1,100,000 SH Call DFND 1,2,3,4,5 1,100,000 0 0
BANK OF AMERICA CORPORATION COM 060505104 27,248 1,750,000 SH Call DFND 1,2,3,4,5 1,750,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 28,140 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 35,175 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
BLUEBIRD BIO INC COM 09609G100 3,147 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
BRF SA SPONSORED ADR 10552T107 10,435 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
CAPITAL ONE FINL CORP COM 14040H105 30,644 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
CEMENTOS PACASMAYO S A A SPON ADR REP 5 15126Q109 3,646 307,909 SH   DFND 1,2,3,4,5 307,909 0 0
CERES INC COM 156773103 5,785 4,192,167 SH   DFND 1,2,3,4 4,192,167 0 0
CHEMOCENTRYX INC COM 16383L106 1,592 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
CITIGROUP INC COM NEW 172967424 15,633 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
COLGATE PALMOLIVE CO COM 194162103 16,303 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
CROWN CASTLE INTL CORP COM 228227104 7,343 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 7,024 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
FORD MTR CO DEL COM PAR $0.01 345370860 20,059 1,300,000 SH Call DFND 1,2,3,4,5 1,300,000 0 0
FREEPORT-MCMORAN COPPER & GO COM 35671D857 7,548 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
FURIEX PHARMACEUTICALS INC COM 36106P101 36,584 870,842 SH   DFND 1,2,3,4,5 870,842 0 0
GENERAL ELECTRIC CO COM 369604103 56,060 2,000,000 SH Call DFND 1,2,3,4,5 2,000,000 0 0
GENERAL MTRS CO COM 37045V100 10,218 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
GENERAL MTRS CO COM 37045V100 12,261 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 8,863 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 13,295 75,000 SH Call DFND 1,2,3,4,5 75,000 0 0
GOOGLE INC CL A 38259P508 22,414 20,000 SH Call DFND 1,2,3,4,5 20,000 0 0
HARTFORD FINL SVCS GROUP INC COM 416515104 41,665 1,150,000 SH Call DFND 1,2,3,4,5 1,150,000 0 0
IMMUNOGEN INC COM 45253H101 24,206 1,650,000 SH   DFND 1,2,3,4,5 1,650,000 0 0
IMMUNOGEN INC COM 45253H101 5,135 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
INTEL CORP COM 458140100 25,955 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,518 216,879 SH   DFND 1,2,3,4 216,879 0 0
ISHARES US HOME CONS ETF 464288752 18,615 750,000 SH Call DFND 1,2,3,4,5 750,000 0 0
LEGGETT & PLATT INC COM 524660107 3,094 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 9,990 5,553,292 SH   DFND 1,2,3,4,5 5,553,292 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 446,074 247,818,843 SH   DFND 1,2,3,4 247,818,843 0 0
LILLY ELI & CO COM 532457108 30,600 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
MARKET VECTORS ETF TR GOLD MINER ETF 57060U100 4,226 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MACYS INC COM 55616P104 5,340 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
MASCO CORP COM 574599106 10,247 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
MEAD JOHNSON NUTRITION CO COM 582839106 16,752 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MERITOR INC COM 59001K100 6,780 650,000 SH   DFND 1,2,3,4,5 650,000 0 0
MERCK & CO INC NEW COM 58933Y105 75,075 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
MGIC INVT CORP WIS COM 552848103 4,220 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
MICRON TECHNOLOGY INC COM 595112103 8,700 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,910 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
MONDELEZ INTL INC CL A 609207105 7,060 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
NEKTAR THERAPEUTICS COM 640268108 18,160 1,600,000 SH   DFND 1,2,3,4,5 1,600,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,540 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 3,048 1,200,000 SH Call DFND 1,2,3,4,5 1,200,000 0 0
OCWEN FINL CORP COM NEW 675746309 4,159 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
OCWEN FINL CORP COM NEW 675746309 13,863 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
PEPSICO INC COM 713448108 24,882 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
PHARMACYCLICS INC COM 716933106 17,454 165,000 SH   DFND 1,2,3,4,5 165,000 0 0
PHARMACYCLICS INC COM 716933106 4,231 40,000 SH Call DFND 1,2,3,4,5 40,000 0 0
QUALCOMM INC COM 747525103 40,838 550,000 SH Call DFND 1,2,3,4,5 550,000 0 0
REALOGY HLDGS CORP COM 75605Y106 8,657 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
REALOGY HLDGS CORP COM 75605Y106 4,947 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SEATTLE GENETICS INC COM 812578102 3,989 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 3,700 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 19,530 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 129,283 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,332 170,000 SH   DFND 1,2,3,4,5 170,000 0 0
SUNPOWER CORP COM 867652406 2,981 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 28,056 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
UNITED CONTL HLDGS INC COM 910047109 15,132 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 1,862 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 1,241 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
VULCAN MATLS CO COM 929160109 17,826 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 946,708 28,749,089 SH   DFND 1,2,3,4 28,749,089 0 0
WELLS FARGO & CO NEW COM 949746101 56,750 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
XOMA CORP DEL COM 98419J107 13,460 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
YUM BRANDS INC COM 988498101 30,244 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
ZOETIS INC CL A 98978V103 9,807 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0