The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 14,327 | 425,000 | SH | DFND | 1,2,3,4,5 | 425,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 1,321 | 410,130 | SH | DFND | 1,2,3,4,5 | 410,130 | 0 | 0 | |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 8,019 | 175,000 | SH | DFND | 1,2,3,4,5 | 175,000 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 18,951 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 880 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| AMAZON COM INC | COM | 023135106 | 16,239 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
| AMBIT BIOSCIENCES CORP | COM | 02318X100 | 1,728 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| AMERICAN INTL GROUP INC | COM NEW | 026874784 | 5,458 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| AMERICAN INTL GROUP INC | COM NEW | 026874784 | 27,290 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| AMGEN INC | COM | 031162100 | 47,348 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| ARAMARK | COM | 03852U106 | 5,176 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 13,680 | 3,000,000 | SH | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 40,421 | 2,015,000 | SH | DFND | 1,2,3,4,5 | 2,015,000 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 22,066 | 1,100,000 | SH | Call | DFND | 1,2,3,4,5 | 1,100,000 | 0 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A NEW | 05348P401 | 11,280 | 2,000,000 | SH | DFND | 1,2,3,4,5 | 2,000,000 | 0 | 0 | |
| AVANIR PHARMACEUTICALS INC | CL A NEW | 05348P401 | 5,640 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| BANK OF AMERICA CORPORATION | COM | 060505104 | 1,537 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| BANK OF AMERICA CORPORATION | COM | 060505104 | 38,425 | 2,500,000 | SH | Call | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 |
| BIOGEN IDEC INC | COM | 09062X103 | 31,531 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 32,660 | 525,000 | SH | DFND | 1,2,3,4,5 | 525,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 24,884 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 9,643 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| BRF SA | SPONSORED ADR | 10552T107 | 12,155 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 38,808 | 800,000 | SH | Call | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 |
| CAPITAL ONE FINL CORP | COM | 14040H105 | 8,260 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| CASTLIGHT HEALTH INC | CL B | 14862Q100 | 3,800 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| CASTLIGHT HEALTH INC | CL B | 14862Q100 | 1,520 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| CERES INC | COM | 156773103 | 5,489 | 8,192,167 | SH | DFND | 1,2,3,4 | 8,192,167 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 1,609 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | |
| CIT GROUP INC | COM NEW | 125581801 | 34,320 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| CITIGROUP INC | COM NEW | 172967424 | 14,130 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| CITIGROUP INC | COM NEW | 172967424 | 23,550 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| COGNIZANT TECHNOLOGY SOLUTIO | CL A | 192446102 | 9,782 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| COLGATE PALMOLIVE CO | COM | 194162103 | 17,045 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| COMCAST CORP NEW | CL A SPL | 20030N200 | 5,333 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| DELPHI AUTOMOTIVE PLC | SHS | G27823106 | 10,311 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
| DELPHI AUTOMOTIVE PLC | SHS | G27823106 | 17,185 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| LILLY ELI & CO | COM | 532457108 | 12,434 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| FREEPORT-MCMORAN COPPER & GO | COM | 35671D857 | 7,300 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| FURIEX PHARMACEUTICALS INC | COM | 36106P101 | 10,618 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| GENERAL ELECTRIC CO | COM | 369604103 | 39,420 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
| GENERAL MTRS CO | COM | 37045V100 | 12,705 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| GENERAL MTRS CO | COM | 37045V100 | 30,855 | 850,000 | SH | Call | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 20,728 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| GOOGLE INC | CL A | 38259P508 | 8,770 | 15,000 | SH | Call | DFND | 1,2,3,4,5 | 15,000 | 0 | 0 |
| GOOGLE INC | CL C | 38259P706 | 28,764 | 50,000 | SH | Call | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 |
| HONEYWELL INTL INC | COM | 438516106 | 9,295 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| IGNYTA INC | COM | 451731103 | 2,727 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| IMMUNOGEN INC | COM | 45253H101 | 17,775 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
| IMMUNOGEN INC | COM | 45253H101 | 6,518 | 550,000 | SH | Call | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 | 21,447 | 380,000 | SH | DFND | 1,2,3,4,5 | 380,000 | 0 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 3,325 | 216,879 | SH | DFND | 1,2,3,4 | 216,879 | 0 | 0 | |
| ISHARES | RUSSELL 2000 ETF | 464287655 | 23,762 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| ISHARES | US HOME CONS ETF | 464288752 | 37,200 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330109 | 15,675 | 455,000 | SH | DFND | 1,2,3,4,5 | 455,000 | 0 | 0 | |
| JPMORGAN CHASE & CO | COM | 46625H100 | 28,810 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 8,941 | 5,553,292 | SH | DFND | 1,2,3,4,5 | 5,553,292 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 398,988 | 247,818,843 | SH | DFND | 1,2,3,4 | 247,818,843 | 0 | 0 | |
| MERCK & CO INC NEW | COM | 58933Y105 | 75,205 | 1,300,000 | SH | Call | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 |
| METLIFE INC | COM | 59156R108 | 50,004 | 900,000 | SH | Call | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 5,000 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 4,850 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 17,307 | 1,350,000 | SH | DFND | 1,2,3,4,5 | 1,350,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 10,256 | 800,000 | SH | Call | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 |
| NEOGEN CORP | COM | 640491106 | 5,059 | 125,000 | SH | DFND | 1,2,3,4,5 | 125,000 | 0 | 0 | |
| NOVAGOLD RES INC | COM NEW | 66987E206 | 5,052 | 1,200,000 | SH | Call | DFND | 1,2,3,4,5 | 1,200,000 | 0 | 0 |
| OCWEN FINL CORP | COM NEW | 675746309 | 3,710 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| OCWEN FINL CORP | COM NEW | 675746309 | 16,695 | 450,000 | SH | Call | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |
| PHARMACYCLICS INC | COM | 716933106 | 24,222 | 270,000 | SH | DFND | 1,2,3,4,5 | 270,000 | 0 | 0 | |
| PHARMACYCLICS INC | COM | 716933106 | 13,457 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| QUALCOMM INC | COM | 747525103 | 15,840 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| RADIAN GROUP INC | COM | 750236101 | 2,962 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| RALPH LAUREN CORP | CL A | 751212101 | 4,017 | 25,000 | SH | DFND | 1,2,3,4,5 | 25,000 | 0 | 0 | |
| REALOGY HLDGS CORP | COM | 75605Y106 | 5,657 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| SFX ENTMT INC | COM | 784178303 | 2,025 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| SOPHIRIS BIO INC | COM NEW | 83578Q209 | 2,240 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| SPDR S&P 500 ETF TRUST | TR UNIT | 78462F103 | 195,720 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| STEMLINE THERAPEUTICS INC | COM | 85858C107 | 2,494 | 170,000 | SH | DFND | 1,2,3,4,5 | 170,000 | 0 | 0 | |
| TEREX CORP NEW | COM | 880779103 | 8,220 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 36,694 | 700,000 | SH | Call | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 |
| UNITED CONTL HLDGS INC | COM | 910047109 | 8,214 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| VULCAN MATLS CO | COM | 929160109 | 12,750 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 579,869 | 28,749,089 | SH | DFND | 1,2,3,4 | 28,749,089 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 4,590 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 3,672 | 800,000 | SH | Call | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 |
| YUM! BRANDS INC | COM | 988498101 | 20,300 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| ZOETIS INC | CL A | 98978V103 | 9,681 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |