The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC COM 00484M106 10,218 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 6,131 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
AGENUS INC COM NEW 00847G705 1,628 410,130 SH   DFND 1,2,3,4,5 410,130 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 10,084 90,000 SH   DFND 1,2,3,4,5 90,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 49,372 475,000 SH   DFND 1,2,3,4,5 475,000 0 0
ALLY FINL INC COM 02005N100 2,953 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 38,800 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 490 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AMAZON COM INC COM 023135106 15,518 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 19,604 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 33,606 600,000 SH Call DFND 1,2,3,4,5 600,000 0 0
ARAMARK COM 03852U106 9,345 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 14,190 3,000,000 SH   DFND 1,2,3,4,5 3,000,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 1,466 310,000 SH Call DFND 1,2,3,4,5 310,000 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 58,455 1,700,000 SH Call DFND 1,2,3,4,5 1,700,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 8,475 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
BANK AMER CORP COM 060505104 42,936 2,400,000 SH Call DFND 1,2,3,4,5 2,400,000 0 0
BIOGEN IDEC INC COM 09062X103 58,385 172,000 SH Call DFND 1,2,3,4,5 172,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 43,392 480,000 SH   DFND 1,2,3,4,5 480,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 27,120 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
BIOTIME INC COM 09066L105 4,782 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLUEBIRD BIO INC COM 09609G100 25,223 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
BLUEBIRD BIO INC COM 09609G100 9,172 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BRF SA SPONSORED ADR 10552T107 11,675 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 23,612 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
CAPITAL ONE FINL CORP COM 14040H105 8,255 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 2,925 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
CERES INC COM 156773103 1,966 8,192,167 SH   DFND 1,2,3,4 8,192,167 0 0
CHEMOCENTRYX INC COM 16383L106 2,732 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
CHEMOCENTRYX INC COM 16383L106 2,732 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
CITIGROUP INC COM NEW 172967424 13,528 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
DELPHI AUTOMOTIVE PLC SHS G27823106 16,362 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
DELPHI AUTOMOTIVE PLC SHS G27823106 7,272 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 4,919 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
DOLLAR GEN CORP NEW COM 256677105 14,140 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 4,672 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
GENERAL ELECTRIC CO COM 369604103 25,270 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
GENERAL MTRS CO COM 37045V100 13,964 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
GENERAL MTRS CO COM 37045V100 29,674 850,000 SH Call DFND 1,2,3,4,5 850,000 0 0
GILEAD SCIENCES INC COM 375558103 9,426 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
GOOGLE INC CL C 38259P706 13,160 25,000 SH   DFND 1,2,3,4,5 25,000 0 0
GOOGLE INC CL C 38259P706 15,792 30,000 SH Call DFND 1,2,3,4,5 30,000 0 0
GRAINGER W W INC COM 384802104 31,861 125,000 SH Call DFND 1,2,3,4,5 125,000 0 0
HALLIBURTON CO COM 406216101 7,866 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A104 5,218 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
IGNYTA INC COM 451731103 2,740 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
IMMUNOGEN INC COM 45253H101 6,100 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
INCYTE CORP COM 45337C102 29,975 410,000 SH   DFND 1,2,3,4,5 410,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,323 216,879 SH   DFND 1,2,3,4 216,879 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 35,886 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
ISIS PHARMACEUTICALS INC COM 464330109 25,005 405,000 SH   DFND 1,2,3,4,5 405,000 0 0
JPMORGAN CHASE & CO COM 46625H100 56,322 900,000 SH Call DFND 1,2,3,4,5 900,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 5,222 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
KITE PHARMA INC COM 49803L109 20,185 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
LENDINGCLUB CORP COM 52603A109 8,855 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 5,053 5,553,292 SH   DFND 1,2,3,4,5 5,553,292 0 0
LEXICON PHARMACEUTICALS INC COM 528872104 361,336 397,072,574 SH   DFND 1,2,3,4 397,072,574 0 0
LINKEDIN CORP COM CL A 53578A108 13,783 60,000 SH   DFND 1,2,3,4,5 60,000 0 0
LINKEDIN CORP COM CL A 53578A108 11,486 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
MARKET VECTORS ETF TR OIL SVCS ETF 57060U191 3,592 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
MASTERCARD INC CL A 57636Q104 15,078 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
MCDONALDS CORP COM 580135101 65,590 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
MERCK & CO INC NEW COM 58933Y105 102,222 1,800,000 SH Call DFND 1,2,3,4,5 1,800,000 0 0
METLIFE INC COM 59156R108 21,636 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
METLIFE INC COM 59156R108 27,045 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 4,630 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
MOBILEYE N V AMSTELVEEN ORD SHS N51488117 8,112 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MORGAN STANLEY COM NEW 617446448 13,580 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
NEKTAR THERAPEUTICS COM 640268108 25,575 1,650,000 SH   DFND 1,2,3,4,5 1,650,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 2,950 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
OCCIDENTAL PETE CORP DEL COM 674599105 12,092 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 2,075 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
PHARMACYCLICS INC COM 716933106 27,509 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
PHARMACYCLICS INC COM 716933106 6,113 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
REALOGY HLDGS CORP COM 75605Y106 5,561 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
REALOGY HLDGS CORP COM 75605Y106 6,674 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
SCHLUMBERGER LTD COM 806857108 8,541 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 287,756 1,400,000 SH Call DFND 1,2,3,4,5 1,400,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 28,755 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
TIME WARNER INC COM NEW 887317303 8,542 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
WEATHERFORD INTL PLC ORD SHS G48833100 4,008 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
WELLS FARGO & CO NEW COM 949746101 27,410 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 731,372 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
XOMA CORP DEL COM 98419J107 4,308 1,200,000 SH   DFND 1,2,3,4,5 1,200,000 0 0
XOMA CORP DEL COM 98419J107 3,877 1,080,000 SH Call DFND 1,2,3,4,5 1,080,000 0 0
YUM BRANDS INC COM 988498101 50,995 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0