The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AGENUS INC COM NEW 00847G705 2,530 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 15,883 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 17,691 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 29,485 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 34,957 435,000 SH   DFND 1,2,3,4,5 435,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,018 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
AMAZON COM INC COM 023135106 12,797 25,000 SH Call DFND 1,2,3,4,5 25,000 0 0
AMERICAN EXPRESS CO COM 025816109 33,359 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
APPLE INC COM 037833100 22,060 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 16,918 3,710,000 SH   DFND 1,2,3,4,5 3,710,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 1,368 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
BANK AMER CORP COM 060505104 15,580 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
BANK AMER CORP COM 060505104 46,740 3,000,000 SH Call DFND 1,2,3,4,5 3,000,000 0 0
BIOGEN INC COM 09062X103 116,724 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 46,341 440,000 SH   DFND 1,2,3,4,5 440,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 10,532 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BIOTIME INC COM 09066L105 3,846 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLUEBIRD BIO INC COM 09609G100 26,948 315,000 SH   DFND 1,2,3,4,5 315,000 0 0
BLUEBIRD BIO INC COM 09609G100 4,278 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 2,059,427 114,987,547 SH   DFND 1,2,3,4 114,987,547 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 29,600 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
CELGENE CORP COM 151020104 70,311 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 3,953 375,000 SH   DFND 1,2,3,4,5 375,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 3,295 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
CERES INC COM NEW 156773400 1,106 1,024,020 SH   DFND 1,2,3,4 1,024,020 0 0
CHEMOCENTRYX INC COM 16383L106 5,445 900,000 SH   DFND 1,2,3,4,5 900,000 0 0
CITIGROUP INC COM NEW 172967424 27,286 550,000 SH Call DFND 1,2,3,4,5 550,000 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 22 5,575 SH   DFND 1,2,3,4 5,575 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 15,774 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ENDO INTL PLC SHS G30401106 34,640 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
GENERAL ELECTRIC CO COM 369604103 50,440 2,000,000 SH Call DFND 1,2,3,4,5 2,000,000 0 0
GENERAL MTRS CO COM 37045V100 13,509 450,000 SH   DFND 1,2,3,4,5 450,000 0 0
GENERAL MTRS CO COM 37045V100 30,020 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
GILEAD SCIENCES INC COM 375558103 29,457 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 86,880 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
GOOGLE INC CL C 38259P706 36,505 60,000 SH Call DFND 1,2,3,4,5 60,000 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A104 2,294 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
HOULIHAN LOKEY INC CL A 441593100 1,635 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
IGNYTA INC COM 451731103 4,171 475,000 SH   DFND 1,2,3,4,5 475,000 0 0
INCYTE CORP COM 45337C102 54,062 490,000 SH   DFND 1,2,3,4,5 490,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,260 216,879 SH   DFND 1,2,3,4 216,879 0 0
ISHARES TR MSCI EMG MKT ETF 464287234 8,195 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
ISIS PHARMACEUTICALS INC COM 464330109 16,168 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
ISIS PHARMACEUTICALS INC COM 464330109 4,042 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
JPMORGAN CHASE & CO COM 46625H100 79,261 1,300,000 SH Call DFND 1,2,3,4,5 1,300,000 0 0
JUMEI INTL HLDG LTD SPONSORED ADR 48138L107 4,935 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
JUMEI INTL HLDG LTD SPONSORED ADR 48138L107 1,481 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 9,562 235,000 SH   DFND 1,2,3,4,5 235,000 0 0
KITE PHARMA INC COM 49803L109 21,715 390,000 SH   DFND 1,2,3,4,5 390,000 0 0
KITE PHARMA INC COM 49803L109 8,352 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
LENDINGCLUB CORP COM 52603A109 15,545 1,175,000 SH   DFND 1,2,3,4,5 1,175,000 0 0
LENDINGCLUB CORP COM 52603A109 4,300 325,000 SH Call DFND 1,2,3,4,5 325,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 8,520 793,327 SH   DFND 1,2,3,4,5 793,327 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 609,223 56,724,651 SH   DFND 1,2,3,4 56,724,651 0 0
LINKEDIN CORP COM CL A 53578A108 23,766 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
MASTERCARD INC CL A 57636Q104 27,036 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
MCDONALDS CORP COM 580135101 19,706 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
MERCK & CO INC NEW COM 58933Y105 24,695 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
METLIFE INC COM 59156R108 58,938 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
MICRON TECHNOLOGY INC COM 595112103 14,980 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
MORGAN STANLEY COM NEW 617446448 7,875 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
MORGAN STANLEY COM NEW 617446448 31,500 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
NANTKWEST INC COM 63016Q102 2,006 175,000 SH   DFND 1,2,3,4,5 175,000 0 0
NEKTAR THERAPEUTICS COM 640268108 19,728 1,800,000 SH   DFND 1,2,3,4,5 1,800,000 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 1,720 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
QUALCOMM INC COM 747525103 26,865 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
REGENXBIO INC COM 75901B107 2,586 117,400 SH   DFND 1,2,3,4,5 117,400 0 0
SERES THERAPEUTICS INC COM 81750R102 5,928 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 28,013 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
SPECTRANETICS CORP COM 84760C107 1,179 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 25,407 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
TIME WARNER INC COM NEW 887317303 10,313 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
WAL-MART STORES INC COM 931142103 107,959 1,665,000 SH Call DFND 1,2,3,4,5 1,665,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 187,848 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
XOMA CORP DEL COM 98419J107 301 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
YUM BRANDS INC COM 988498101 11,993 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
YUM BRANDS INC COM 988498101 19,988 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0