The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AGENUS INC | COM NEW | 00847G705 | 2,497 | 550,000 | SH | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 | |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 17,853 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 6,492 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 24,381 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 24,381 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 44,717 | 475,000 | SH | DFND | 1,2,3,4,5 | 475,000 | 0 | 0 | |
| AMERICAN EXPRESS CO | COM | 258161090 | 13,910 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
| APPLE INC | COM | 378331000 | 63,156 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 15,656 | 3,710,000 | SH | DFND | 1,2,3,4,5 | 3,710,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 1,266 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| BANK AMER CORP | COM | 605051040 | 16,830 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| BANK AMER CORP | COM | 605051040 | 67,320 | 4,000,000 | SH | Call | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 | 107,223 | 350,000 | SH | Call | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 28,809 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 10,476 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| BIOTIME INC | COM | 09066L105 | 5,256 | 1,282,050 | SH | DFND | 1,2,3,4,5 | 1,282,050 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 23,119 | 360,000 | SH | DFND | 1,2,3,4,5 | 360,000 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 3,211 | 50,000 | SH | Call | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 |
| BLUE BUFFALO PET PRODS INC | COM | 09531U102 | 2,151,417 | 114,987,547 | SH | DFND | 1,2,3,4 | 114,987,547 | 0 | 0 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 34,395 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| CELGENE CORP | COM | 151020104 | 11,976 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| CELGENE CORP | COM | 151020104 | 95,808 | 800,000 | SH | Call | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM | 15117B103 | 5,880 | 375,000 | SH | DFND | 1,2,3,4,5 | 375,000 | 0 | 0 | |
| CELLECTIS S A | SPONSORED ADS | 15117K103 | 6,516 | 210,000 | SH | DFND | 1,2,3,4,5 | 210,000 | 0 | 0 | |
| CERES INC | COM NEW | 156773400 | 338 | 1,024,020 | SH | DFND | 1,2,3,4 | 1,024,020 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 7,290 | 900,000 | SH | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 | |
| CITIGROUP INC | COM NEW | 172967424 | 12,938 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| COLUCID PHARMACEUTICALS INC | COM | 19716T101 | 47 | 5,575 | SH | DFND | 1,2,3,4 | 5,575 | 0 | 0 | |
| DELPHI AUTOMOTIVE PLC | SHS | G27823106 | 8,573 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| DELTA AIR LINES INC DEL | COM NEW | 247361702 | 5,069 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| DIMENSION THERAPEUTICS INC | COM | 25433V105 | 1,974 | 175,000 | SH | DFND | 1,2,3,4,5 | 175,000 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 18,366 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| GENERAL ELECTRIC CO | COM | 369604103 | 15,575 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| GENERAL MTRS CO | COM | 37045V100 | 13,604 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| GENERAL MTRS CO | COM | 37045V100 | 34,010 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 30,357 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | COM | 38141G104 | 135,173 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
| IGNYTA INC | COM | 451731103 | 6,365 | 475,000 | SH | DFND | 1,2,3,4,5 | 475,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 61,817 | 570,000 | SH | DFND | 1,2,3,4,5 | 570,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 5,423 | 50,000 | SH | Call | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 21,676 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 6,193 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 2,514 | 216,879 | SH | DFND | 1,2,3,4 | 216,879 | 0 | 0 | |
| ISHARES TR | NASDQ BIOTEC ETF | 464287556 | 33,833 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| JPMORGAN CHASE & CO | COM | 46625H100 | 13,206 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| JPMORGAN CHASE & CO | COM | 46625H100 | 56,126 | 850,000 | SH | Call | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 |
| JUMEI INTL HLDG LTD | SPONSORED ADR | 48138L107 | 4,530 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 8,354 | 190,000 | SH | DFND | 1,2,3,4,5 | 190,000 | 0 | 0 | |
| KITE PHARMA INC | COM | 49803L109 | 21,567 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| KITE PHARMA INC | COM | 49803L109 | 9,243 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| LENDINGCLUB CORP | COM | 52603A109 | 11,879 | 1,075,000 | SH | DFND | 1,2,3,4,5 | 1,075,000 | 0 | 0 | |
| LENDINGCLUB CORP | COM | 52603A109 | 3,591 | 325,000 | SH | Call | DFND | 1,2,3,4,5 | 325,000 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 10,559 | 793,327 | SH | DFND | 1,2,3,4,5 | 793,327 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 755,005 | 56,724,650 | SH | DFND | 1,2,3,4 | 56,724,650 | 0 | 0 | |
| LINKEDIN CORP | COM CL A | 53578A108 | 22,508 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| MASTERCARD INC | CL A | 57636Q104 | 29,208 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| MERCK & CO INC NEW | COM | 58933Y105 | 26,410 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| METLIFE INC | COM | 59156R108 | 72,315 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 | 14,160 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| MOBILEYE N V AMSTELVEEN | ORD SHS | N51488117 | 14,798 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 9,543 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 31,810 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
| NANTKWEST INC | COM | 63016Q102 | 3,899 | 225,000 | SH | DFND | 1,2,3,4,5 | 225,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 26,960 | 1,600,000 | SH | DFND | 1,2,3,4,5 | 1,600,000 | 0 | 0 | |
| PARNELL PHARMACEUT HLDGS LTD | SHS | Q73622104 | 1,940 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| QUALCOMM INC | COM | 747525103 | 8,223 | 164,500 | SH | DFND | 1,2,3,4,5 | 164,500 | 0 | 0 | |
| QUALCOMM INC | COM | 747525103 | 24,993 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
| REGENXBIO INC | COM | 75901B107 | 2,656 | 160,000 | SH | DFND | 1,2,3,4,5 | 160,000 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,858 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
| SERES THERAPEUTICS INC | COM | 81750R102 | 6,141 | 175,000 | SH | DFND | 1,2,3,4,5 | 175,000 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 50,968 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 10,530 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| SPECTRANETICS CORP | COM | 84760C107 | 1,506 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 29,538 | 450,000 | SH | Call | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 |
| TIME WARNER INC | COM NEW | 887317303 | 9,701 | 150,000 | SH | Call | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 |
| VISA INC | COM CL A | 92826C839 | 13,571 | 175,000 | SH | DFND | 1,2,3,4,5 | 175,000 | 0 | 0 | |
| WAL-MART STORES INC | COM | 931142103 | 102,065 | 1,665,000 | SH | Call | DFND | 1,2,3,4,5 | 1,665,000 | 0 | 0 |
| WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 671,307 | 29,443,300 | SH | DFND | 1,2,3,4 | 29,443,300 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 532 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
| YUM BRANDS INC | COM | 988498101 | 21,915 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
| YUM BRANDS INC | COM | 988498101 | 18,263 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |