The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCURAY INC | COM | 004397105 | 28,827 | 5,771,250 | SH | DFND | 0 | 5,771,250 | 0 | ||
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 24,221 | 913,674 | SH | DFND | 0 | 913,674 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 12,005 | 1,002,953 | SH | DFND | 0 | 1,002,953 | 0 | ||
| AERCAP HOLDINGS NV | SHS | N00985106 | 80,074 | 2,093,991 | SH | DFND | 0 | 2,093,991 | 0 | ||
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 39,351 | 2,218,198 | SH | DFND | 0 | 2,218,198 | 0 | ||
| AETNA INC NEW | COM | 00817Y108 | 70,341 | 642,915 | SH | DFND | 0 | 642,915 | 0 | ||
| AIMMUNE THERAPEUTICS INC | COM | 00900T107 | 25,222 | 996,112 | SH | DFND | 0 | 996,112 | 0 | ||
| ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 36,230 | 1,105,911 | SH | DFND | 0 | 1,105,911 | 0 | ||
| ALLERGAN PLC | CALL | G0177J908 | 2,518 | 314,700 | SH | Call | DFND | 0 | 314,700 | 0 | |
| ALLERGAN PLC | SHS | G0177J108 | 165,475 | 608,789 | SH | DFND | 0 | 608,789 | 0 | ||
| ALLY FINL INC | COM | 02005N100 | 47,860 | 2,348,383 | SH | DFND | 0 | 2,348,383 | 0 | ||
| BARD C R INC | COM | 067383109 | 14,079 | 75,570 | SH | DFND | 0 | 75,570 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 21,030 | 1,027,553 | SH | DFND | 0 | 544,460 | 0 | ||
| BRISTOL MYERS SQUIBB CO | CALL | 110122908 | 419 | 2,537,100 | SH | Call | DFND | 0 | 2,537,100 | 0 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 122,886 | 2,075,777 | SH | DFND | 0 | 2,075,777 | 0 | ||
| BROADCOM CORP | CL A | 111320107 | 65,405 | 1,271,730 | SH | DFND | 0 | 1,271,730 | 0 | ||
| CLOVIS ONCOLOGY INC | NOTE 2.500% 9/1 | 189464AB6 | 8,045 | 4,805,000 | PRN | DFND | 0 | 4,805,000 | 0 | ||
| CLOVIS ONCOLOGY INC | COM | 189464100 | 234,763 | 2,552,887 | SH | DFND | 0 | 2,552,887 | 0 | ||
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 5,923 | 295,579 | SH | DFND | 0 | 295,579 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 9,750 | 273,965 | SH | DFND | 0 | 273,965 | 0 | ||
| EAGLE MATERIALS INC | COM | 26969P108 | 40,149 | 586,800 | SH | DFND | 0 | 586,800 | 0 | ||
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 111,949 | 787,430 | SH | DFND | 0 | 787,430 | 0 | ||
| FACEBOOK INC | CL A | 30303M102 | 98,184 | 1,092,146 | SH | DFND | 0 | 1,092,146 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 3,716 | 506,920 | SH | DFND | 0 | 506,920 | 0 | ||
| FORTUNE BRANDS HOME & SEC IN | COM | 34964C106 | 48,331 | 1,018,137 | SH | DFND | 0 | 1,018,137 | 0 | ||
| GILEAD SCIENCES INC | COM | 375558103 | 110,559 | 1,125,974 | SH | DFND | 0 | 1,125,974 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 31,992 | 758,816 | SH | DFND | 0 | 758,816 | 0 | ||
| GOOGLE INC | CL A | 38259P508 | 42,330 | 66,310 | SH | DFND | 0 | 66,310 | 0 | ||
| HCA HOLDINGS INC | COM | 40412C101 | 183,113 | 2,367,026 | SH | DFND | 0 | 2,367,026 | 0 | ||
| HERON THERAPEUTICS INC | COM | 427746102 | 72,289 | 2,962,656 | SH | DFND | 0 | 2,962,656 | 0 | ||
| HOLOGIC INC | COM | 436440101 | 54,917 | 1,403,438 | SH | DFND | 0 | 1,403,438 | 0 | ||
| HOME DEPOT INC | COM | 437076102 | 60,787 | 526,343 | SH | DFND | 0 | 526,343 | 0 | ||
| HORTONWORKS INC | COM | 440894103 | 12,904 | 589,489 | SH | DFND | 0 | 589,489 | 0 | ||
| HUMANA INC | COM | 444859102 | 33,461 | 186,935 | SH | DFND | 0 | 186,935 | 0 | ||
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 43,296 | 326,002 | SH | DFND | 0 | 326,002 | 0 | ||
| JD COM INC | SPON ADR CL A | 47215P106 | 44,128 | 1,693,324 | SH | DFND | 0 | 1,693,324 | 0 | ||
| JUNO THERAPEUTICS INC | COM | 48205A109 | 2,996 | 73,631 | SH | DFND | 0 | 73,631 | 0 | ||
| KERYX BIOPHARMACEUTICALS INC | COM | 492515101 | 344 | 97,687 | SH | DFND | 0 | 97,687 | 0 | ||
| KITE PHARMA INC | COM | 49803L109 | 38,006 | 682,577 | SH | DFND | 0 | 682,577 | 0 | ||
| KYTHERA BIOPHARMACEUTICALS I | COM | 501570105 | 1,544 | 20,589 | SH | DFND | 0 | 20,589 | 0 | ||
| LIBERTY GLOBAL PLC | SHS CL C | G5480U120 | 27,933 | 680,964 | SH | DFND | 0 | 680,964 | 0 | ||
| LILLY ELI & CO | COM | 532457108 | 92,573 | 1,106,139 | SH | DFND | 0 | 1,106,139 | 0 | ||
| LINKEDIN CORP | COM CL A | 53578A108 | 28,871 | 151,848 | SH | DFND | 0 | 151,848 | 0 | ||
| MACQUARIE INFRASTRUCTURE COR | COM | 55608B105 | 59,612 | 798,443 | SH | DFND | 0 | 798,443 | 0 | ||
| MASTERCARD INC | CL A | 57636Q104 | 45,068 | 500,093 | SH | DFND | 0 | 500,093 | 0 | ||
| MAXLINEAR INC | CL A | 57776J100 | 1,013 | 81,398 | SH | DFND | 0 | 81,398 | 0 | ||
| MCKESSON CORP | CALL | 58155Q903 | 26 | 343,100 | SH | Call | DFND | 0 | 343,100 | 0 | |
| MEDICINES CO | COM | 584688105 | 48,955 | 1,289,652 | SH | DFND | 0 | 1,289,652 | 0 | ||
| MERCK & CO INC NEW | PUT | 58933Y955 | 1,750 | 1,301,300 | SH | Put | DFND | 0 | 1,301,300 | 0 | |
| MGIC INVT CORP WIS | COM | 552848103 | 38,010 | 4,104,737 | SH | DFND | 0 | 4,104,737 | 0 | ||
| MOLINA HEALTHCARE INC | COM | 60855R100 | 15,742 | 228,635 | SH | DFND | 0 | 228,635 | 0 | ||
| NETFLIX INC | COM | 64110L106 | 27,946 | 270,633 | SH | DFND | 0 | 270,633 | 0 | ||
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 12,101 | 17,458,000 | PRN | DFND | 0 | 17,458,000 | 0 | ||
| PALO ALTO NETWORKS INC | COM | 697435105 | 92,854 | 539,851 | SH | DFND | 0 | 539,851 | 0 | ||
| PENUMBRA INC | COM | 70975L107 | 15,289 | 381,270 | SH | DFND | 0 | 381,270 | 0 | ||
| PFIZER INC | CALL | 717081903 | 265 | 2,207,400 | SH | Call | DFND | 0 | 2,207,400 | 0 | |
| PFIZER INC | COM | 717081103 | 165,826 | 5,279,394 | SH | DFND | 0 | 5,279,394 | 0 | ||
| PRICELINE GRP INC | COM NEW | 741503403 | 56,745 | 45,878 | SH | DFND | 0 | 45,878 | 0 | ||
| PTC THERAPEUTICS INC | CALL | 69366J900 | 1,306 | 428,200 | SH | Call | DFND | 0 | 428,200 | 0 | |
| RADIUS HEALTH INC | COM NEW | 750469207 | 39,994 | 577,034 | SH | DFND | 0 | 577,034 | 0 | ||
| REGENXBIO INC | COM | 75901B107 | 2,364 | 107,305 | SH | DFND | 0 | 107,305 | 0 | ||
| RITE AID CORP | COM | 767754104 | 21,751 | 3,583,282 | SH | DFND | 0 | 3,583,282 | 0 | ||
| ROCKWELL AUTOMATION INC | CALL | 773903909 | 87 | 388,600 | SH | Call | DFND | 0 | 388,600 | 0 | |
| SERVICENOW INC | COM | 81762P102 | 69,233 | 996,872 | SH | DFND | 0 | 996,872 | 0 | ||
| TELADOC INC | COM | 87918A105 | 305 | 13,670 | SH | DFND | 0 | 13,670 | 0 | ||
| TEVA PHARMACEUTICAL INDS LTD | CALL | 881624909 | 938 | 938,300 | SH | Call | DFND | 0 | 938,300 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | CALL | 881624909 | 71 | 1,774,700 | SH | Call | DFND | 0 | 1,774,700 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 86,884 | 1,538,865 | SH | DFND | 0 | 1,538,865 | 0 | ||
| TEXTRON INC | COM | 883203101 | 13,452 | 357,388 | SH | DFND | 0 | 357,388 | 0 | ||
| THORATEC CORP | COM NEW | 885175307 | 27,365 | 432,577 | SH | DFND | 0 | 432,577 | 0 | ||
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 170,013 | 1,465,502 | SH | DFND | 0 | 1,465,502 | 0 | ||
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 | 64,557 | 517,243 | SH | DFND | 0 | 517,243 | 0 | ||
| VULCAN MATLS CO | COM | 929160109 | 82,947 | 929,900 | SH | DFND | 0 | 929,900 | 0 | ||
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 179,427 | 2,159,167 | SH | DFND | 0 | 2,159,167 | 0 | ||
| ZELTIQ AESTHETICS INC | COM | 98933Q108 | 14,275 | 445,686 | SH | DFND | 0 | 445,686 | 0 | ||