The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMAG PHARMACEUTICALS INC COM 00163U106 8,526 282,420 SH   DFND   0 282,420 0
HERON THERAPEUTICS INC COM 427746102 74,158 2,777,464 SH   DFND   0 2,777,464 0
ACCURAY INC COM 004397105 34,588 5,124,148 SH   DFND   0 5,124,148 0
ACORDA THERAPEUTICS INC COM 00484M106 55,077 1,287,443 SH   DFND   0 1,287,443 0
ALLERGAN PLC SHS G0177J108 153,893 492,459 SH   DFND   0 492,459 0
AERCAP HOLDINGS NV SHS N00985106 126,136 2,922,514 SH   DFND   0 2,922,514 0
AERIE PHARMACEUTICALS INC COM 00771V108 57,826 2,374,797 SH   DFND   0 2,374,797 0
AETNA INC NEW COM 00817Y108 56,584 523,340 SH   DFND   0 523,340 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 62,428 1,890,030 SH   DFND   0 1,890,030 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 85,482 1,051,826 SH   DFND   0 1,051,826 0
ALPHABET INC CAP STK CL A 02079K305 107,004 137,536 SH   DFND   0 137,536 0
AMAZON COM INC COM 023135106 99,396 147,060 SH   DFND   0 147,060 0
ATLASSIAN CORP PLC CL A G06242104 2,959 98,357 SH   DFND   0 98,357 0
BLACKROCK INC COM 09247X101 43,995 129,200 SH   DFND   0 129,200 0
BLUEBIRD BIO INC COM 09609G100 42,889 667,840 SH   DFND   0 667,840 0
BLUEPRINT MEDICINES CORP COM 09627Y109 26,557 1,008,232 SH   DFND   0 1,008,232 0
BRISTOL MYERS SQUIBB CO CALL 110122908 60,336 877,100 SH Call DFND   0 877,100 0
BRISTOL MYERS SQUIBB CO COM 110122108 196,316 2,853,840 SH   DFND   0 2,853,840 0
CELGENE CORP COM 151020104 19,149 159,895 SH   DFND   0 159,895 0
SCHWAB CHARLES CORP NEW COM 808513105 91,531 2,779,577 SH   DFND   0 2,779,577 0
CHARTER COMMUNICATIONS INC D CL A NEW 16117M305 26,609 145,325 SH   DFND   0 145,325 0
CLOVIS ONCOLOGY INC CALL 189464900 11,379 325,100 SH Call DFND   0 325,100 0
CLOVIS ONCOLOGY INC COM 189464100 72,745 2,078,440 SH   DFND   0 2,078,440 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 3,988 4,637,000 PRN   DFND   0 4,637,000 0
COHERUS BIOSCIENCES INC COM 19249H103 3,964 172,638 SH   DFND   0 172,638 0
DEXCOM INC COM 252131107 14,418 176,038 SH   DFND   0 176,038 0
DIMENSION THERAPEUTICS INC COM 25433V105 8,385 815,359 SH   DFND   0 815,359 0
EDWARDS LIFESCIENCES CORP COM 28176E108 92,730 1,174,098 SH   DFND   0 1,174,098 0
FACEBOOK INC CL A 30303M102 54,920 524,747 SH   DFND   0 524,747 0
FORTUNE BRANDS HOME & SEC IN COM 34964C106 49,825 897,740 SH   DFND   0 897,740 0
GILEAD SCIENCES INC COM 375558103 6,697 66,187 SH   DFND   0 66,187 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 22,760 703,987 SH   DFND   0 703,987 0
HCA HOLDINGS INC COM 40412C101 27,175 401,817 SH   DFND   0 401,817 0
HOLOGIC INC COM 436440101 54,813 1,416,728 SH   DFND   0 1,416,728 0
HOME DEPOT INC COM 437076102 36,604 276,778 SH   DFND   0 276,778 0
HORTONWORKS INC COM 440894103 24,175 1,103,877 SH   DFND   0 1,103,877 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 71,946 511,850 SH   DFND   0 511,850 0
JUNO THERAPEUTICS INC COM 48205A109 6,626 150,684 SH   DFND   0 150,684 0
KITE PHARMA INC COM 49803L109 34,287 556,433 SH   DFND   0 556,433 0
KURA ONCOLOGY INC COM 50127T109 12,551 1,494,169 SH   DFND   0 1,494,169 0
LAM RESEARCH CORP COM 512807108 63,920 804,833 SH   DFND   0 804,833 0
MACQUARIE INFRASTRUCTURE COR COM 55608B105 40,914 563,552 SH   DFND   0 563,552 0
MAXLINEAR INC CL A 57776J100 1,200 81,443 SH   DFND   0 81,443 0
MCKESSON CORP COM 58155Q103 14,324 72,627 SH   DFND   0 72,627 0
MEDICINES CO COM 584688105 77,165 2,066,547 SH   DFND   0 2,066,547 0
MICROSOFT CORP COM 594918104 27,304 492,143 SH   DFND   0 492,143 0
MOLINA HEALTHCARE INC COM 60855R100 35,354 587,956 SH   DFND   0 587,956 0
MYOKARDIA INC COM 62857M105 10,243 698,694 SH   DFND   0 698,694 0
NETFLIX INC COM 64110L106 48,813 426,764 SH   DFND   0 426,764 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 10,034 16,788,000 PRN   DFND   0 16,788,000 0
PALO ALTO NETWORKS INC COM 697435105 144,233 818,852 SH   DFND   0 818,852 0
PENUMBRA INC COM 70975L107 2,504 46,531 SH   DFND   0 46,531 0
REGENXBIO INC COM 75901B107 1,977 119,092 SH   DFND   0 119,092 0
RITE AID CORP COM 767754104 15,190 1,937,467 SH   DFND   0 1,937,467 0
SAGE THERAPEUTICS INC COM 78667J108 2,382 40,850 SH   DFND   0 40,850 0
SERVICENOW INC COM 81762P102 41,716 481,927 SH   DFND   0 481,927 0
SYNCHRONY FINL COM 87165B103 59,900 1,969,737 SH   DFND   0 1,969,737 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 122,153 1,860,952 SH   DFND   0 1,860,952 0
TEXTRON INC COM 883203101 66,082 1,573,009 SH   DFND   0 1,573,009 0
THERAVANCE INC COM 88338T104 24,365 2,311,681 SH   DFND   0 2,311,681 0
UNITED RENTALS INC COM 911363109 28,774 396,663 SH   DFND   0 396,663 0
UNITEDHEALTH GROUP INC COM 91324P102 20,551 174,697 SH   DFND   0 174,697 0
UNIVERSAL HLTH SVCS INC CL B 913903100 68,576 573,905 SH   DFND   0 573,905 0
VOYAGER THERAPEUTICS INC COM 92915B106 17,088 896,634 SH   DFND   0 896,634 0
VULCAN MATLS CO COM 929160109 97,181 1,023,285 SH   DFND   0 1,023,285 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 193,063 2,267,196 SH   DFND   0 2,267,196 0
ZELTIQ AESTHETICS INC COM 98933Q108 14,661 513,884 SH   DFND   0 513,884 0