The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
COVIDIEN PLC SHS G2554F113 12,873 211,245 SH   SOLE   211,245 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 16,774 610,615 SH   SOLE   610,615 0 0
ACASTI PHARMA INC CL A SHS 00430K105 366 154,386 SH   SOLE   154,386 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 63,154 5,858,400 SH   SOLE   5,858,400 0 0
AEGERION PHARMACEUTICALS INC COM 00767e102 199,655 2,328,341 SH   SOLE   2,328,341 0 0
AETNA INC NEW COM 00817Y108 133 2,070 SH   SOLE   2,070 0 0
ALERE INC COM 01449J105 135 4,430 SH   SOLE   4,430 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 5,489 868,500 SH Put SOLE   868,500 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 915 144,800 SH Call SOLE   144,800 0 0
AMGEN INC COM 031162100 10,261 91,675 SH   SOLE   91,675 0 0
AMSURG CORP COM 03232P405 136 3,415 SH   SOLE   3,415 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 10,342 973,868 SH   SOLE   973,868 0 0
ANIKA THERAPEUTICS INC COM 035255108 3,442 144,067 SH   SOLE   144,067 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 1,734 431,456 SH   SOLE   431,456 0 0
ARENA PHARMACEUTICALS INC COM 040047102 13,481 2,558,100 SH Put SOLE   2,558,100 0 0
ARRAY BIOPHARMA INC COM 04269X105 3,563 572,870 SH   SOLE   572,870 0 0
ASTEX PHARMACEUTICALS INC COM 04624B103 400 47,098 SH   SOLE   47,098 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 140 2,700 SH   SOLE   2,700 0 0
ATHERSYS INC COM 04744L106 3,526 2,150,117 SH   SOLE   2,150,117 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 816 193,000 SH Put SOLE   193,000 0 0
AXOGEN INC COM 05463X106 20 4,500 SH   SOLE   4,500 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 1,387 190,588 SH   SOLE   190,588 0 0
CIGNA CORPORATION COM 125509109 17,128 222,848 SH   SOLE   222,848 0 0
CVS CAREMARK CORPORATION COM 126650100 131 2,300 SH   SOLE   2,300 0 0
CAPITAL SR LIVING CORP COM 140475104 12,988 614,089 SH   SOLE   614,089 0 0
CELL THERAPEUTICS INC COM NPV NEW 2012 150934883 11,338 6,994,673 SH   SOLE   6,994,673 0 0
CELGENE CORP COM 151020104 56,201 364,619 SH   SOLE   364,619 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 1,711 48,300 SH Call SOLE   48,300 0 0
CENTENE CORP DEL COM 15135B101 151 2,355 SH   SOLE   2,355 0 0
CHELSEA THERAPEUTICS INTL LT COM 163428105 10,220 3,418,365 SH   SOLE   3,418,365 0 0
CHAMPIONS ONCOLOGY INC RSTD COM 15870p109 2,726 1,558,244 SH   SOLE   1,558,244 0 0
CLOVIS ONCOLOGY INC COM 189464100 11,838 194,701 SH   SOLE   194,701 0 0
COMBIMATRIX CORPORATION *W EXP 05/01/201 20009T121 2 5,000 SH   SOLE   5,000 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 142 3,415 SH   SOLE   3,415 0 0
CORONADO BIOSCIENCES INC COM 21976U109 3,519 501,900 SH Put SOLE   501,900 0 0
CUTERA INC COM 232109108 110 12,400 SH   SOLE   12,400 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 131 2,310 SH   SOLE   2,310 0 0
DEXCOM INC COM 252131107 2,047 72,550 SH   SOLE   72,550 0 0
DYAX CORP COM 26746e103 11,613 1,692,912 SH   SOLE   1,692,912 0 0
ENDOCYTE INC COM 29269A102 2,573 193,000 SH Put SOLE   193,000 0 0
ENDOCYTE INC COM 29269A102 5,581 418,715 SH   SOLE   418,715 0 0
EXACT SCIENCES CORP COM 30063P105 20,630 1,748,314 SH   SOLE   1,748,314 0 0
FURIEX PHARMACEUTICALS INC COM 36106P101 220 5,000 SH   SOLE   5,000 0 0
GILEAD SCIENCES INC COM 375558103 54,324 864,070 SH   SOLE   864,070 0 0
HANGER INC COM NEW 41043F208 138 4,080 SH   SOLE   4,080 0 0
HEALTHSOUTH CORP COM NEW 421924309 144 4,190 SH   SOLE   4,190 0 0
HEALTH NET INC COM 42222G108 14,385 453,780 SH   SOLE   453,780 0 0
HEARTWARE INTL INC COM 422368100 366 5,000 SH   SOLE   5,000 0 0
IMMUNOMEDICS INC COM 452907108 4,573 737,505 SH   SOLE   737,505 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 3,402 195,155 SH   SOLE   195,155 0 0
INTERMUNE INC COM 45884X103 4,614 300,000 SH   SOLE   300,000 0 0
ISHARES NASDQ BIOTEC ETF 464287556 30,350 144,800 SH Put SOLE   144,800 0 0
ISHARES RUSSELL 2000 ETF 464287655 10,288 96,500 SH Put SOLE   96,500 0 0
ISIS PHARMACEUTICALS INC COM 464330109 7,238 192,800 SH   SOLE   192,800 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 2,018 200,000 SH   SOLE   200,000 0 0
KYTHERA BIOPHARMACEUTICALS I COM 501570105 126 2,765 SH   SOLE   2,765 0 0
LIFEPOINT HOSPITALS INC COM 53219L109 140 2,995 SH   SOLE   2,995 0 0
MGC DIAGNOSTICS CORP COM 552768103 1,910 174,449 SH   SOLE   174,449 0 0
MAGELLAN HEALTH SVCS INC COM NEW 559079207 137 2,290 SH   SOLE   2,290 0 0
MANNKIND CORP COM 56400P201 1,650 289,500 SH   SOLE   289,500 0 0
MAZOR ROBOTICS LTD SPONSORED ADS 57886P103 2,993 177,078 SH   SOLE   177,078 0 0
MEDGENICS INC COM NEW 58436Q203 1,170 150,000 SH   SOLE   150,000 0 0
MEDIVATION INC COM 58501N101 2,892 48,250 SH   SOLE   48,250 0 0
MEDNAX INC COM 58502B106 138 1,375 SH   SOLE   1,375 0 0
MOLINA HEALTHCARE INC COM 60855R100 128 3,590 SH   SOLE   3,590 0 0
MYLAN INC COM 628530107 17,570 460,305 SH   SOLE   460,305 0 0
MYRIAD GENETICS INC COM 62855J104 1,370 58,300 SH Call SOLE   58,300 0 0
NPS PHARMACEUTICALS INC COM 62936P103 9,726 305,762 SH   SOLE   305,762 0 0
NANOSPHERE INC COM 63009F105 679 339,500 SH   SOLE   339,500 0 0
NAVIDEA BIOPHARMACEUTICALS I COM 63937X103 309 116,500 SH Put SOLE   116,500 0 0
NEOSTEM INC COM PAR $.001 640650404 2,835 331,593 SH   SOLE   331,593 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 17,120 5,383,857 SH   SOLE   5,383,857 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,277 289,500 SH Put SOLE   289,500 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 48,344 4,270,704 SH   SOLE   4,270,704 0 0
OMNICARE INC COM 681904108 140 2,525 SH   SOLE   2,525 0 0
ONCOTHYREON INC COM 682324108 994 482,500 SH   SOLE   482,500 0 0
ONYX PHARMACEUTICALS INC COM 683399109 69,451 556,944 SH   SOLE   556,944 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 13,078 272,034 SH   SOLE   272,034 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 849 169,068 SH   SOLE   169,068 0 0
PSIVIDA CORP COM 74440J101 3,173 772,000 SH   SOLE   772,000 0 0
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 21,828 376,350 SH   SOLE   376,350 0 0
REPLIGEN CORP COM 759916109 757 68,300 SH Put SOLE   68,300 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 5,172 193,000 SH Call SOLE   193,000 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 39,710 1,481,733 SH   SOLE   1,481,733 0 0
SANGAMO BIOSCIENCES INC COM 800677106 10,123 965,000 SH   SOLE   965,000 0 0
SANTARUS INC COM 802817304 12,023 532,243 SH   SOLE   532,243 0 0
SAREPTA THERAPEUTICS INC COM 803607100 130,897 2,772,069 SH   SOLE   2,772,069 0 0
SPECTRANETICS CORP COM 84760C107 2,589 154,079 SH   SOLE   154,079 0 0
STEMCELLS INC COM NEW 85857R204 389 231,600 SH   SOLE   231,600 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 4,086 90,208 SH   SOLE   90,208 0 0
SYNTA PHARMACEUTICALS CORP COM 87162T206 15,026 2,381,236 SH   SOLE   2,381,236 0 0
TEKMIRA PHARMACEUTICALS CORP COM NEW 87911B209 1,112 159,309 SH   SOLE   159,309 0 0
TESARO INC COM 881569107 58,639 1,513,644 SH   SOLE   1,513,644 0 0
TRANSGENOMIC INC COM 89365k206 838 2,207,500 SH   SOLE   2,207,500 0 0
UROPLASTY INC COM NEW 917277204 1,006 303,989 SH   SOLE   303,989 0 0
VCA ANTECH INC COM 918194101 129 4,715 SH   SOLE   4,715 0 0
VANDA PHARMACEUTICALS INC COM 921659108 1,057 96,500 SH Put SOLE   96,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 5,284 482,600 SH Call SOLE   482,600 0 0
VANDA PHARMACEUTICALS INC COM 921659108 9,510 868,500 SH   SOLE   868,500 0 0
VERASTEM INC COM 92337C104 3,001 241,065 SH   SOLE   241,065 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 34,277 452,095 SH   SOLE   452,095 0 0
VICAL INC COM 925602104 500 400,000 SH Call SOLE   400,000 0 0
VIVUS INC COM 928551100 2,692 289,500 SH Put SOLE   289,500 0 0
WALGREEN CO COM 931422109 10,107 187,870 SH   SOLE   187,870 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 9,211 132,081 SH   SOLE   132,081 0 0
XENOPORT INC COM 98411C100 274 48,250 SH   SOLE   48,250 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 124 13,703 SH   SOLE   13,703 0 0