The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMN HEALTHCARE SERVICES INC COM 001744101 123 7,855 SH   SOLE   7,855 0 0
AASTROM BIOSCIENCES INC COM PAR$ 00253U404 3,135 1,100,000 SH   SOLE   1,100,000 0 0
ABIOMED INC COM 003654100 621 25,000 SH   SOLE   25,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 27,184 1,097,914 SH   SOLE   1,097,914 0 0
ACASTI PHARMA INC CL A SHS 00430K105 1,982 2,573,645 SH   SOLE   2,573,645 0 0
ACCELERON PHARMA INC COM 00434H108 13,457 445,000 SH   SOLE   445,000 0 0
ACHAOGEN INC COM 004449104 538 60,000 SH   SOLE   60,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 36,092 6,574,060 SH   SOLE   6,574,060 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 1,697 170,000 SH   SOLE   170,000 0 0
AEGERION PHARMACEUTICALS INC COM 00767E102 12,242 366,754 SH   SOLE   366,754 0 0
AETNA INC NEW COM 00817Y108 106 1,308 SH   SOLE   1,308 0 0
ALLERGAN INC COM 018490102 8,910 50,000 SH   SOLE   50,000 0 0
ALLIANCE HEALTHCARE SRVCS IN COM PAR $0.01 018606301 79 3,500 SH   SOLE   3,500 0 0
AMICUS THERAPEUTICS INC COM 03152W109 73,420 12,339,444 SH   SOLE   12,339,444 0 0
AMSURG CORP COM 03232P405 118 2,348 SH   SOLE   2,348 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 919 478,456 SH   SOLE   478,456 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 5,527 296,978 SH   SOLE   296,978 0 0
ALLIQUA INC COM 00771V108 5,441 1,121,951 SH   SOLE   1,121,951 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 866 130,000 SH   SOLE   130,000 0 0
ARDELYX INC COM 039697107 2,175 153,077 SH   SOLE   153,077 0 0
ARNO THERAPEUTICS COM 042564203 2,746 2,034,721 SH   SOLE   2,034,721 0 0
ARROWHEAD RESH CORP COM NEW 042797209 18,426 1,247,495 SH   SOLE   1,247,495 0 0
AUSPEX PHARMACEUTICALS INC COM 05211J102 2,567 100,000 SH   SOLE   100,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 5,483 460,000 SH   SOLE   460,000 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 5,230 306,000 SH   SOLE   306,000 0 0
BIOTA PHARMACEUTIALS INC COM 090694100 626 253,400 SH   SOLE   253,400 0 0
CATALYST PHARM PARTNERS INC COM 4888U101 2,490 750,000 SH   SOLE   750,000 0 0
CELGENE CORP COM 151020104 35,775 377,448 SH   SOLE   377,448 0 0
CELLULAR DYNAMICS INTL INC COM 15117V109 1 164 SH   SOLE   164 0 0
CENTENE CORP DEL COM 15135B101 111 1,336 SH   SOLE   1,336 0 0
CHAMPIONS ONCOLOGY COM 15870P109 1,203 1,625,744 SH   SOLE   1,625,744 0 0
CHARLES RIV LABS INTL INC COM 159864107 111 1,860 SH   SOLE   1,860 0 0
CHIMERIX INC COM 16934W106 3,535 128,000 SH   SOLE   128,000 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 130 2,400 SH   SOLE   2,400 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,402 30,917 SH   SOLE   30,917 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 116 2,123 SH   SOLE   2,123 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,798 215,809 SH   SOLE   215,809 0 0
DURECT CORP COM 266605104 1,333 907,064 SH   SOLE   907,064 0 0
DYAX CORP COM 26746E103 28,695 2,835,498 SH   SOLE   2,835,498 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 120 3,040 SH   SOLE   3,040 0 0
EPIZYME INC COM 29428V104 7,696 283,890 SH   SOLE   283,890 0 0
EXACTECH INC COM 30064E109 102 4,464 SH   SOLE   4,464 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,760 150,000 SH   SOLE   150,000 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 8,729 610,000 SH   SOLE   610,000 0 0
GENVEC INC COM NEW 37246C307 1,706 820,000 SH   SOLE   820,000 0 0
GENTIVA HEALTH SERVICES INC COM 37247A102 118 7,052 SH   SOLE   7,052 0 0
GREATBATCH INC COM 39153L106 104 2,444 SH   SOLE   2,444 0 0
HCA HOLDINGS INC COM 40412C101 16,241 230,306 SH   SOLE   230,306 0 0
HEALTH INS INNOVATIONS INC COM CL A 42225K106 1,591 131,025 SH   SOLE   131,025 0 0
HERON THERAPEUTICS INC COM 427746102 7,375 885,352 SH   SOLE   885,352 0 0
HILL ROM HLDGS INC COM 431475102 110 2,657 SH   SOLE   2,657 0 0
INSMED INC COM PAR $.01 457669307 7,830 600,000 SH   SOLE   600,000 0 0
KERYX BIOPHARMACEUTICALS COM 492515101 2,750 200,000 SH Put SOLE   200,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 2,403 250,000 SH   SOLE   250,000 0 0
LANNET INC COM 516012101 6,147 134,569 SH   SOLE   134,569 0 0
LION BIOTECHNOLOGIES COM 53619R102 20,839 2,914,549 SH   SOLE   2,914,549 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 105 2,245 SH   SOLE   2,245 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,227 327,488 SH   SOLE   327,488 0 0
MACROGENICS INC COM 556099109 4,466 213,703 SH   SOLE   213,703 0 0
MAGELLAN HEALTH INC COM NEW 559079207 120 2,189 SH   SOLE   2,189 0 0
MANNKIND CORP COM 56400P201 1,182 200,000 SH Put SOLE   200,000 0 0
MCKESSON CORP COM 58155Q103 103 527 SH   SOLE   527 0 0
MEDGENICS INC COM NEW 58436Q203 286 55,073 SH   SOLE   55,073 0 0
MERGE HEALTHCARE INC COM 589499102 96 43,478 SH   SOLE   43,478 0 0
MYLAN INC COM 628530107 2,275 50,000 SH   SOLE   50,000 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 9,072 6,700,444 SH   SOLE   6,700,444 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 71,538 4,565,267 SH   SOLE   4,565,267 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 10,233 653,000 SH Put SOLE   653,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 263 20,000 SH   SOLE   20,000 0 0
ONCOTHYREON INC COM 682324108 624 325,000 SH   SOLE   325,000 0 0
OPHTHOTECH CORP COM 683745103 20,250 520,165 SH   SOLE   520,165 0 0
OTONOMY INC COM 68906L105 20,098 837,400 SH   SOLE   837,400 0 0
OXIGENE INC COM PAR$.001 691828404 266 123,518 SH   SOLE   123,518 0 0
PDL BIOPHARMA INC COM 69329Y104 76 10,183 SH   SOLE   10,183 0 0
PTC THERAPEUTICS INC COM 69366J200 29,563 671,736 SH   SOLE   671,736 0 0
PERNIX THERAPEUTICS INC COM 71426V108 192 25,000 SH Call SOLE   25,000 0 0
PHARMACYCLICS INC COM 716933106 4,697 40,000 SH   SOLE   40,000 0 0
PFENEX INC COM 717071104 2,944 400,000 SH   SOLE   400,000 0 0
PROVIDENCE SVC CORP COM 743815102 122 2,532 SH   SOLE   2,532 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 2,624 11,000 SH   SOLE   11,000 0 0
RECEPTOS INC COM 756207106 19,477 313,594 SH   SOLE   313,594 0 0
RELYPSA INC COM 759531106 16,085 762,705 SH   SOLE   762,705 0 0
RETROPHIN INC COM 761299106 12,438 1,379,137 SH   SOLE   1,379,137 0 0
SAGE THERAPEUTICS INC COM 78667J108 6,573 208,676 SH   SOLE   208,676 0 0
SANGAMO BIOSCIENCES INC COM 800677106 8,628 800,000 SH   SOLE   800,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 54,790 2,596,691 SH   SOLE   2,596,691 0 0
Sarepta Therapeutics Inc COM 803607100 26,375 1,250,000 SH Call SOLE   1,250,000 0 0
SCICLONE PHARMACEUTICALS INC COM 80862K104 110 16,035 SH   SOLE   16,035 0 0
SELECT MED HLDGS CORP COM 81619Q105 108 9,016 SH   SOLE   9,016 0 0
SMITH & NEPHEW PLC SPDN ADR NEW 83175M205 1,091 12,963 SH   SOLE   12,963 0 0
SPECTRANETICS CORP COM 84760C107 3,677 138,371 SH   SOLE   138,371 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 2,856 400,000 SH Put SOLE   400,000 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 2,856 400,000 SH Call SOLE   400,000 0 0
SYMMETRY MED INC COM 871546206 112 11,148 SH   SOLE   11,148 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 4,009 67,500 SH   SOLE   67,500 0 0
TESARO INC COM 881569107 19,067 708,284 SH   SOLE   708,284 0 0
THORATEC CORP COM NEW 885175307 3,943 147,501 SH   SOLE   147,501 0 0
THRESHOLD PHARMACEUTICAL INC COM NEW 885807206 578 160,000 SH   SOLE   160,000 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 2,725 180,000 SH   SOLE   180,000 0 0
TRANSGENOMIC INC COM NEW 89365K305 692 183,957 SH   SOLE   183,957 0 0
TRANSENTERIX INC COM NEW 89366M201 5,720 1,311,941 SH   SOLE   1,311,941 0 0
TREVENA INC COM 89532E109 4,943 770,000 SH   SOLE   770,000 0 0
TRIPLE-S MGMT CORP CL B 896749108 117 5,880 SH   SOLE   5,880 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 115 1,101 SH   SOLE   1,101 0 0
UROPLASTY INC COM NEW 917277204 1,743 697,287 SH   SOLE   697,287 0 0
VANDA PHARMACEUTICALS INC COM 921659108 7,266 700,000 SH Put SOLE   700,000 0 0
VERSARTIS INC COM 92529L102 9,253 487,262 SH   SOLE   487,262 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 26,970 240,142 SH   SOLE   240,142 0 0
WALGREEN CO COM 931422109 2,964 50,000 SH   SOLE   50,000 0 0
WELLPOINT INC COM 94973V107 108 901 SH   SOLE   901 0 0
XENCOR INC COM 98401F105 17,900 1,922,707 SH   SOLE   1,922,707 0 0
ZAFGEN INC COM 98885E103 5,404 275,000 SH   SOLE   275,000 0 0
ZIMMER HLDGS INC COM 98956P102 25,389 252,500 SH   SOLE   252,500 0 0
ACTAVIS PLC SHS G0083B108 3,619 15,000 SH   SOLE   15,000 0 0
ICON PLC SHS G4705A100 140 2,440 SH   SOLE   2,440 0 0
PROTHENA CORP PLC SHS G72800108 6,648 300,000 SH   SOLE   300,000 0 0
QUOTIENT LTD SHS G73268107 2,493 263,844 SH   SOLE   263,844 0 0
ALCOBRA LTD SHS M2239P109 8,291 537,000 SH Call SOLE   537,000 0 0
ALCOBRA LTD SHS M2239P109 7,519 487,000 SH Put SOLE   487,000 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 645 75,000 SH   SOLE   75,000 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 1,503 150,000 SH   SOLE   150,000 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 21,684 140,935 SH   SOLE   140,935 0 0
AFFIMED THERAPEUTICS B V COM N01045108 6,300 99,989 SH   SOLE   99,989 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,719 100,000 SH   SOLE   100,000 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 1,208 210,000 SH   SOLE   210,000 0 0