The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ANI PHARMACEUTICALS INC COM 00182C103 17,622 312,500 SH   SOLE   312,500 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 7,885 7,500,000 PRN   SOLE   7,500,000 0 0
ABIOMED INC COM 003654100 1,903 50,000 SH Call SOLE   50,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 34,712 1,093,281 SH   SOLE   1,093,281 0 0
ACASTI PHARMA INC CL A SHS 00430K105 1,286 2,573,645 SH   SOLE   2,573,645 0 0
ACCELERON PHARMA INC COM 00434H108 12,375 317,636 SH   SOLE   317,636 0 0
ACHAOGEN INC COM 004449104 783 60,000 SH   SOLE   60,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 44,243 6,574,060 SH   SOLE   6,574,060 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 1,300 106,100 SH   SOLE   106,100 0 0
AETNA INC NEW COM 00817Y108 230 2,586 SH   SOLE   2,586 0 0
AGENUS INC COM NEW 00847G705 1,599 402,717 SH   SOLE   402,717 0 0
ALERE INC COM 01449J105 3,724 98,000 SH   SOLE   98,000 0 0
ALIMERA SCIENCES INC COM 016259103 2,115 381,900 SH   SOLE   381,900 0 0
ALLERGAN INC COM 018490102 17,556 82,583 SH   SOLE   82,583 0 0
ALLIQUA BIOMEDIC COM 19621200 5,946 1,121,951 SH   SOLE   1,121,951 0 0
AMICUS THERAPEUTICS INC COM 03152W109 120,136 14,439,444 SH   SOLE   14,439,444 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 795 503,156 SH   SOLE   503,156 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 6,332 301,222 SH   SOLE   301,222 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 975 130,000 SH   SOLE   130,000 0 0
ARDELYX INC COM 039697107 4,831 255,728 SH   SOLE   255,728 0 0
ARNO THERAPEUTICS, INC COM 042564203 2,746 2,034,721 SH   SOLE   2,034,721 0 0
BARD C R INC COM 067383109 228 1,367 SH   SOLE   1,367 0 0
BECTON DICKINSON & CO COM 075887109 11,133 80,000 SH   SOLE   80,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 24,109 1,046,402 SH   SOLE   1,046,402 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 7,277 605,407 SH   SOLE   605,407 0 0
BIOSPECIFICS TECHNOLOGIES CO COM 090931106 234 6,065 SH   SOLE   6,065 0 0
BLUEBIRD BIO INC COM 09609G100 20,637 225,000 SH   SOLE   225,000 0 0
CIGNA CORPORATION COM 125509109 228 2,219 SH   SOLE   2,219 0 0
CAMBREX CORP COM 132011107 248 11,488 SH   SOLE   11,488 0 0
CAPITAL SR LIVING CORP COM 140475104 6,228 250,000 SH   SOLE   250,000 0 0
CELGENE CORP COM 151020104 16,395 146,567 SH   SOLE   146,567 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 1,825 100,000 SH   SOLE   100,000 0 0
CELLULAR DYNAMICS INTL INC COM 15117V109 1 164 SH   SOLE   164 0 0
CEMPRA INC COM 15130J109 5,819 247,500 SH   SOLE   247,500 0 0
CENTENE CORP DEL COM 15135B101 258 2,484 SH   SOLE   2,484 0 0
CHAMPIONS ONCOLOGY COM 15870P109 812 1,625,744 SH   SOLE   1,625,744 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 4,977 74,023 SH   SOLE   74,023 0 0
CIVITAS SOLUTIONS INC COM 17887R102 231 13,585 SH   SOLE   13,585 0 0
CLOVIS ONCOLOGY INC COM 189464100 288 5,138 SH   SOLE   5,138 0 0
COHERUS BIOSCIENCES INC COM 19249H103 7,148 438,000 SH   SOLE   438,000 0 0
CYBERONICS INC COM 23251P102 248 4,454 SH   SOLE   4,454 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 3,054 112,622 SH   SOLE   112,622 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 2,919 313,583 SH   SOLE   313,583 0 0
DERMIRA INC COM 24983L104 2,753 152,000 SH   SOLE   152,000 0 0
DURECT CORP COM 266605104 716 907,064 SH   SOLE   907,064 0 0
DYAX CORP COM 26746E103 26,039 1,852,000 SH   SOLE   1,852,000 0 0
ENDOLOGIX INC COM 29266S106 3,211 210,000 SH   SOLE   210,000 0 0
EPIZYME INC COM 29428V104 8,164 432,619 SH   SOLE   432,619 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 12,233 302,500 SH   SOLE   302,500 0 0
EXACTECH INC COM 30064E109 245 10,374 SH   SOLE   10,374 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 4,192 155,256 SH   SOLE   155,256 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 3,678 644,111 SH   SOLE   644,111 0 0
GALENA BIOPHARMA INC COM 363256108 302 200,000 SH Put SOLE   200,000 0 0
GENVEC INC COM NEW 37246C307 2,226 1,040,344 SH   SOLE   1,040,344 0 0
HCA HOLDINGS INC COM 40412C101 3,570 48,639 SH   SOLE   48,639 0 0
HEALTH NET INC COM 42222G108 269 5,025 SH   SOLE   5,025 0 0
HEALTH INS INNOVATIONS INC COM CL A 42225K106 687 96,000 SH   SOLE   96,000 0 0
HERON THERAPEUTICS INC COM 427746102 6,700 666,042 SH   SOLE   666,042 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 259 15,323 SH   SOLE   15,323 0 0
INSMED INC COM PAR $.01 457669307 10,610 685,812 SH   SOLE   685,812 0 0
JUNO THERAPEUTICS INC COM 48205A109 2,611 50,000 SH   SOLE   50,000 0 0
KERYX BIOPHARMACEUTICALS COM 492515101 2,830 200,000 SH Put SOLE   200,000 0 0
LHC GROUP INC COM 50187A107 302 9,688 SH   SOLE   9,688 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 665 36,040 SH   SOLE   36,040 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 4,666 252,915 SH   SOLE   252,915 0 0
LANNET INC COM 516012101 188 4,392 SH   SOLE   4,392 0 0
LION BIOSCIENCES COM 53619R102 25,298 3,214,549 SH   SOLE   3,214,549 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,152 336,287 SH   SOLE   336,287 0 0
MACROGENICS INC COM 556099109 7,569 215,815 SH   SOLE   215,815 0 0
MANNKIND CORP COM 56400P201 1,043 200,000 SH Put SOLE   200,000 0 0
MEDGENICS INC COM NEW 58436Q203 2,602 514,224 SH   SOLE   514,224 0 0
MERGE HEALTHCARE INC COM 589499102 293 82,427 SH   SOLE   82,427 0 0
MYLAN INC COM 628530107 4,296 76,210 SH   SOLE   76,210 0 0
NANOSPHERE INC COM 63009F105 277 707,566 SH   SOLE   707,566 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 12,825 6,750,444 SH   SOLE   6,750,444 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 35,744 1,600,000 SH Put SOLE   1,600,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 79,648 3,565,267 SH   SOLE   3,565,267 0 0
NEVRO CORP COM 64157F103 6,828 176,563 SH   SOLE   176,563 0 0
OHR PHARMACEUTICAL INC COM NEW 67778H200 50 6,000 SH   SOLE   6,000 0 0
ONCOTHYREON INC COM 682324108 618 325,000 SH   SOLE   325,000 0 0
OPHTHOTECH CORP COM 683745103 19,267 429,386 SH   SOLE   429,386 0 0
OTONOMY INC COM 68906L105 15,142 454,306 SH   SOLE   454,306 0 0
OXIGENE INC COM PAR$.001 691828404 199 123,518 SH   SOLE   123,518 0 0
PDL BIOPHARMA INC COM 69329Y104 232 30,151 SH   SOLE   30,151 0 0
PTC THERAPEUTICS INC COM 69366J200 34,776 671,736 SH   SOLE   671,736 0 0
PAREXEL INTL CORP COM 699462107 223 4,005 SH   SOLE   4,005 0 0
PFENEX INC COM 717071104 2,962 404,665 SH   SOLE   404,665 0 0
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106 237 7,526 SH   SOLE   7,526 0 0
PLASMATECH BIOPHARMACEUTICAL COM 72754H109 4,375 1,250,000 SH   SOLE   1,250,000 0 0
PLASMATECH BIOPHARMACEUTICAL *W EXP 10/24/201 72754H117 1,000 1,250,000 SH   SOLE   1,250,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 708 25,000 SH   SOLE   25,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,860 275,000 SH   SOLE   275,000 0 0
PSIVIDA CORP COM 74440J101 1,294 315,000 SH   SOLE   315,000 0 0
QUIDEL CORP COM 74838J101 4,121 142,500 SH   SOLE   142,500 0 0
RECEPTOS INC COM 756207106 35,699 291,394 SH   SOLE   291,394 0 0
RELYPSA INC COM 759531106 38,166 1,239,142 SH   SOLE   1,239,142 0 0
REPLIGEN CORP COM 759916109 1,980 100,000 SH Put SOLE   100,000 0 0
RETROPHIN INC COM 761299106 23,754 1,940,725 SH   SOLE   1,940,725 0 0
RITE AID CORP COM 767754104 318 42,385 SH   SOLE   42,385 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,580 70,484 SH   SOLE   70,484 0 0
SANGAMO BIOSCIENCES INC COM 800677106 12,168 800,000 SH   SOLE   800,000 0 0
Sarepta Therapeutics Inc COM 803607100 6,512 450,000 SH Call SOLE   450,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 40,695 2,812,352 SH   SOLE   2,812,352 0 0
SCICLONE PHARMACEUTICALS INC COM 80862K104 262 29,942 SH   SOLE   29,942 0 0
SEATTLE GENETICS INC /WA COM 812578102 29 900 SH Call SOLE   900 0 0
SELECT MED HLDGS CORP COM 81619Q105 192 13,365 SH   SOLE   13,365 0 0
SHIRE PLC SPONSORED ADR 82481R106 2,125 10,000 SH   SOLE   10,000 0 0
SIENTRA INC COM 82621J105 621 37,000 SH   SOLE   37,000 0 0
SKILLED HEALTHCARE GROUP INC CL A 83066R107 268 31,293 SH   SOLE   31,293 0 0
SMITH & NEPHEW PLC SPDN ADR NEW 83175M205 2,477 67,407 SH   SOLE   67,407 0 0
SPECTRANETICS CORP COM 84760C107 565 16,335 SH   SOLE   16,335 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 1,275 500,000 SH   SOLE   500,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 185 22,285 SH   SOLE   22,285 0 0
SURGICAL CARE AFFILIATES INC COM 86881L106 259 7,702 SH   SOLE   7,702 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 3,847 75,913 SH   SOLE   75,913 0 0
TESARO INC COM 881569107 32,852 883,359 SH   SOLE   883,359 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 3,971 100,000 SH   SOLE   100,000 0 0
THORATEC CORP COM NEW 885175307 3,246 100,000 SH Call SOLE   100,000 0 0
THORATEC CORP COM NEW 885175307 12,739 392,465 SH   SOLE   392,465 0 0
THRESHOLD PHARMACEUTICAL INC COM NEW 885807206 509 160,000 SH   SOLE   160,000 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 7,154 485,338 SH   SOLE   485,338 0 0
TRANSGENOMIC INC COM NEW 89365K305 253 126,084 SH   SOLE   126,084 0 0
TRANSENTERIX INC COM NEW 89366M201 6,099 2,095,708 SH   SOLE   2,095,708 0 0
TRIPLE-S MGMT CORP CL B 896749108 254 10,605 SH   SOLE   10,605 0 0
U S PHYSICAL THERAPY INC COM 90337L108 216 5,156 SH   SOLE   5,156 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 248 2,233 SH   SOLE   2,233 0 0
UROPLASTY INC COM NEW 917277204 1,579 766,349 SH   SOLE   766,349 0 0
VANDA PHARMACEUTICALS INC COM 921659108 1,432 100,000 SH Put SOLE   100,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 8,592 600,000 SH Call SOLE   600,000 0 0
VERICEL CORP COM 92346J108 2,584 850,000 SH   SOLE   850,000 0 0
VERSARTIS INC COM 92529L102 19,740 931,171 SH   SOLE   931,171 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 11,880 100,000 SH Put SOLE   100,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 13,068 110,000 SH   SOLE   110,000 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1,546 20,292 SH   SOLE   20,292 0 0
XENCOR INC COM 98401F105 30,912 1,927,171 SH   SOLE   1,927,171 0 0
XOMA LTD COM 98419J107 1 200 SH Call SOLE   200 0 0
XENON PHARMACEUTICALS INC COM 98420N105 4,444 225,000 SH   SOLE   225,000 0 0
ZAFGEN INC COM 98885E103 8,583 278,313 SH   SOLE   278,313 0 0
ZIMMER HLDGS INC COM 98956P102 17,477 154,093 SH   SOLE   154,093 0 0
ACTAVIS PLC SHS G0083B108 3,884 15,088 SH   SOLE   15,088 0 0
PROTHENA CORP PLC SHS G72800108 5,135 247,336 SH   SOLE   247,336 0 0
QUOTIENT LTD SHS G73268107 8,169 453,870 SH   SOLE   453,870 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 435 75,000 SH   SOLE   75,000 0 0
NEURODERM LTD ORD SHS M74231107 4,914 350,000 SH   SOLE   350,000 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 1,424 152,609 SH   SOLE   152,609 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 22,825 154,028 SH   SOLE   154,028 0 0
VASCULAR BIOGENICS LTD ORD SHS M96885104 2,955 500,000 SH   SOLE   500,000 0 0
AFFIMED N V COM N01045108 6,236 1,005,820 SH   SOLE   1,005,820 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 2,167 100,000 SH   SOLE   100,000 0 0
UNIQURE NV SHS N90064101 2,901 195,856 SH   SOLE   195,856 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 888 214,100 SH   SOLE   214,100 0 0