The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ANI PHARMACEUTICALS INC COM 00182C103 19,252 307,784 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8,621 7,500,000 PRN   SOLE   0 0 0
ABIOMED INC COM 003654100 716 10,000 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 19,562 600,240 SH   SOLE   0 0 0
ACASTI PHARMA INC CL A SHS 00430K105 1,134 2,365,600 SH   SOLE   0 0 0
ACCELERON PHARMA INC COM 00434H108 12,790 336,036 SH   SOLE   0 0 0
ACHAOGEN INC COM 004449104 586 60,000 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 25,376 6,574,060 SH   SOLE   0 0 0
AEGERION PHARMACEUTICALS INC COM 00767E102 9,973 381,100 SH   SOLE   0 0 0
AETNA INC NEW COM 00817Y108 275 2,586 SH   SOLE   0 0 0
AGENUS INC COM NEW 00847G705 929 181,117 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 4,329 150,000 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS COM 01438T106 3,634 357,000 SH   SOLE   0 0 0
ALIMERA SCIENCES INC COM 016259103 1,161 231,900 SH   SOLE   0 0 0
ALLIQUA BIOMEDIC COM 19621200 5,834 1,121,951 SH   SOLE   0 0 0
AMICUS THERAPEUTICS INC COM 03152W109 157,101 14,439,444 SH   SOLE   0 0 0
AMSURG CORP COM 03232P405 205 3,328 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 7,166 1,603,156 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CO RP COM 03820J100 6,021 301,222 SH   SOLE   0 0 0
AQUINOX PHARMACEUTICALS IN C COM 03842B101 1,115 130,000 SH   SOLE   0 0 0
ARDELYX INC COM 039697107 4,136 315,955 SH   SOLE   0 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 346 41,949 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC COM 42564203 1,179 2,034,721 SH   SOLE   0 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 174 10,000 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,627 425,000 SH   SOLE   0 0 0
AUSPEX PHARMACEUTICALS INC COM 05211J102 602 6,000 SH   SOLE   0 0 0
AVINGER INC COM 053734109 1,248 112,500 SH   SOLE   0 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 24,245 1,046,402 SH   SOLE   0 0 0
BIOGEN INC COM 09062X103 7,685 18,200 SH   SOLE   0 0 0
BLUEBIRD BIO INC COM 09609G100 16,304 135,000 SH   SOLE   0 0 0
BOVIE MEDICAL CORP COM 10211F100 478 200,000 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 1,780 400,000 SH   SOLE   0 0 0
BROOKDALE SR LIVING INC COM 112463104 189 5,000 SH   SOLE   0 0 0
CIGNA CORPORATION COM 125509109 255 1,970 SH   SOLE   0 0 0
CAMBREX CORP COM 132011107 291 7,331 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 15,694 605,000 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 35 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC COM 14149Y108 232 2,574 SH   SOLE   0 0 0
CATALENT INC COM 148806102 200 6,429 SH   SOLE   0 0 0
CATALYST PHARM PARTNERS INC COM 14888U101 5,196 1,200,000 SH   SOLE   0 0 0
CELGENE CORP COM 151020104 3,455 29,967 SH   SOLE   0 0 0
CELADON GROUP INC COM 15117E107 1,894 100,000 SH Put SOLE   0 0 0
CELADON GROUP INC COM 15117E107 8,987 474,500 SH Call SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 52 1,500 SH   SOLE   0 0 0
CELLULAR DYNAMICS INTL INC COM 15117V109 3 164 SH   SOLE   0 0 0
CEMPRA INC COM 15130J109 19,642 572,500 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY COM 15870P109 3,082 4,403,680 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 6,686 70,000 SH   SOLE   0 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,608 85,288 SH   SOLE   0 0 0
CYTOKINETICS INC COM NEW 23282W605 205 30,227 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 0 2 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 2,908 343,284 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 2,333 152,000 SH   SOLE   0 0 0
DURECT CORP COM 266605104 1,732 907,064 SH   SOLE   0 0 0
DYAX CORP COM 26746E103 6,702 400,000 SH Put SOLE   0 0 0
DYAX CORP COM 26746E103 29,774 1,777,000 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 506 12,088 SH   SOLE   0 0 0
ENDOLOGIX INC COM 29266S106 9,645 565,000 SH   SOLE   0 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9 102 SH   SOLE   0 0 0
EXACTECH INC COM 30064E109 203 7,905 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS IN C COM 33830X104 5,121 224,129 SH   SOLE   0 0 0
GENVEC INC COM NEW 37246C307 1,811 615,844 SH   SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 981 10,000 SH   SOLE   0 0 0
GREATBATCH INC COM 39153L106 254 4,391 SH   SOLE   0 0 0
HCA HOLDINGS INC COM 40412C101 3,762 50,000 SH   SOLE   0 0 0
HEALTH NET INC COM 42222G108 249 4,109 SH   SOLE   0 0 0
HYPERION THERAPEUTICS INC COM 44915N101 317 6,913 SH   SOLE   0 0 0
ILLUMINA INC COM 452327109 531 2,859 SH   SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 2,625 600,000 SH Put SOLE   0 0 0
IMPRIVATA INC COM 45323J103 700 50,000 SH   SOLE   0 0 0
INCYTE CORP COM 45337C102 917 10,000 SH   SOLE   0 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 853 61,000 SH   SOLE   0 0 0
INSMED INC COM PAR $.01 457669307 12,185 585,812 SH   SOLE   0 0 0
INVITAE CORP COM 46185L103 2,765 165,000 SH   SOLE   0 0 0
ISHARES TR HDG MSCI GERMN 46434V704 2,426 85,000 SH   SOLE   0 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 1,074 84,380 SH   SOLE   0 0 0
LHC GROUP INC COM 50187A107 195 5,917 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 4,628 252,915 SH   SOLE   0 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 247 1,956 SH   SOLE   0 0 0
LANNET INC COM 516012101 297 4,392 SH   SOLE   0 0 0
LIFEPOINT HOSPITALS INC COM 53219L109 222 3,025 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 32,873 2,714,549 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,475 336,287 SH   SOLE   0 0 0
MACROGENICS INC COM 556099109 3,332 106,208 SH   SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 205 2,900 SH   SOLE   0 0 0
MANNKIND CORP COM 56400P201 1 100 SH Call SOLE   0 0 0
MCKESSON CORP COM 58155Q103 230 1,015 SH   SOLE   0 0 0
MEDGENICS INC COM NEW 58436Q203 5,146 639,225 SH   SOLE   0 0 0
MERGE HEALTHCARE INC COM 589499102 368 82,427 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES COM 603380106 4,052 810,537 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 10,935 6,750,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 148,566 3,741,267 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 26,700 557,056 SH   SOLE   0 0 0
ONCOTHYREON INC COM 682324108 1,508 925,000 SH   SOLE   0 0 0
OTONOMY INC COM 68906L105 16,986 480,387 SH   SOLE   0 0 0
OXIGENE INC COM PAR$.001 691828404 180 123,518 SH   SOLE   0 0 0
PHARMACYCLICS INC COM 716933106 3,071 12,000 SH   SOLE   0 0 0
PFENEX INC COM 717071104 13,811 866,423 SH   SOLE   0 0 0
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106 241 6,809 SH   SOLE   0 0 0
PLASMATECH BIOPHARMACEUTICAL COM 72754H109 3,925 1,250,000 SH   SOLE   0 0 0
PLASMATECH BIOPHARMACEUTICAL *W EXP 10/24/201 72754H117 1,163 1,250,000 SH   SOLE   0 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 13,476 355,000 SH   SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 3,198 275,000 SH   SOLE   0 0 0
PSIVIDA CORP COM 74440J101 1,244 315,000 SH   SOLE   0 0 0
RADIUS HEALTH INC COM NEW 750469207 3,046 74,000 SH   SOLE   0 0 0
RADNET INC COM 750491102 223 26,525 SH   SOLE   0 0 0
RAPTOR PHARMACEUTICAL CORP COM 75382F106 2,872 264,200 SH   SOLE   0 0 0
RECEPTOS INC COM 756207106 19,588 118,794 SH   SOLE   0 0 0
RELYPSA INC COM 759531106 52,451 1,454,142 SH   SOLE   0 0 0
REPLIGEN CORP COM 759916109 3,036 100,000 SH Put SOLE   0 0 0
RETROPHIN INC COM 761299106 66,728 2,784,980 SH   SOLE   0 0 0
RITE AID CORP COM 767754104 218 25,063 SH   SOLE   0 0 0
SAGE THERAPEUTICS INC COM 78667J108 3,540 70,484 SH   SOLE   0 0 0
SANGAMO BIOSCIENCES INC COM 800677106 12,544 800,000 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 9,960 750,000 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 29,278 2,204,652 SH   SOLE   0 0 0
SHIRE PLC SPONSORED ADR 82481R106 7,179 30,000 SH   SOLE   0 0 0
SPARK THERAPEUTICS INC COM 84652J103 1,163 15,000 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1,147 79,245 SH   SOLE   0 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 1,715 700,000 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC NOTE 7.500% 868459AB4 6,650 2,915,000 PRN   SOLE   0 0 0
SURGICAL CARE AFFILIATES INC COM 86881L106 241 7,020 SH   SOLE   0 0 0
SYNERGETICS USA INC COM 87160G107 117 21,786 SH   SOLE   0 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 449 8,500 SH   SOLE   0 0 0
TESARO INC COM 881569107 56,158 978,359 SH   SOLE   0 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 3,664 100,000 SH   SOLE   0 0 0
THORATEC CORP COM NEW 885175307 4,189 100,000 SH Call SOLE   0 0 0
THORATEC CORP COM NEW 885175307 12,567 300,000 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 5,484 458,338 SH   SOLE   0 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 1,404 100,000 SH   SOLE   0 0 0
TRANSGENOMIC INC COM NEW 89365K305 1 357 SH   SOLE   0 0 0
TRANSENTERIX INC COM NEW 89366M201 3,893 1,328,668 SH   SOLE   0 0 0
TRIPLE-S MGMT CORP CL B 896749108 211 10,605 SH   SOLE   0 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 255 1,481 SH   SOLE   0 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 263 2,233 SH   SOLE   0 0 0
UROPLASTY INC COM NEW 917277204 1,179 966,349 SH   SOLE   0 0 0
VANDA PHARMACEUTICALS INC COM 921659108 930 100,000 SH Call SOLE   0 0 0
VANDA PHARMACEUTICALS INC COM 921659108 930 100,000 SH Put SOLE   0 0 0
VBI VACCINES INC. COM 91790E102 6,786 2,610,356 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 2,180 589,297 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 24,161 1,546,471 SH   SOLE   0 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1,719 20,292 SH   SOLE   0 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 246 2,690 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 29,947 1,954,785 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,795 225,000 SH   SOLE   0 0 0
ZIMMER HLDGS INC COM 98956P102 21,247 180,793 SH   SOLE   0 0 0
ZS PHARMA INC COM 98979G105 7,860 186,777 SH   SOLE   0 0 0
ACTAVIS PLC SHS G0083B108 14,638 49,185 SH   SOLE   0 0 0
ICON PLC SHS G4705A100 204 2,898 SH   SOLE   0 0 0
MEDTRONIC PLC SHS G5960L103 390 5,000 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 10,702 550,870 SH   SOLE   0 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 706 75,000 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 4,697 350,000 SH   SOLE   0 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 4,736 33,574 SH   SOLE   0 0 0
AFFIMED N V COM N01045108 5,076 805,820 SH   SOLE   0 0 0
MYLAN N V SHS EURO N59465109 305 5,133 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 25,227 1,039,332 SH   SOLE   0 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 964 196,500 SH   SOLE   0 0 0