The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ANI PHARMACEUTICALS INC COM 00182C103 20,300 327,157 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8,488 7,500,000 PRN   SOLE   0 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 2,378 470,000 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC *W EXP 12/19/201 00289Y115 2,250 1,250,000 SH   SOLE   0 0 0
ABIOMED INC COM 3654100 657 10,000 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 4225108 17,181 410,240 SH   SOLE   0 0 0
ACASTI PHARMA INC CL A SHS 00430K105 745 2,365,600 SH   SOLE   0 0 0
ACCELERON PHARMA INC COM 00434H108 8,734 276,036 SH   SOLE   0 0 0
ACHAOGEN INC COM 4449104 362 60,000 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 27,874 6,574,060 SH   SOLE   0 0 0
AETNA INC NEW COM 00817Y108 1,286 10,086 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 6,749 869,800 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC COM NEW 19621200 10,128 1,921,951 SH   SOLE   0 0 0
AMICUS THERAPEUTICS INC COM 03152W109 204,318 14,439,444 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 10,363 1,202,156 SH   SOLE   0 0 0
ANTHEM INC COM 36752103 236 1,436 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 4,616 300,922 SH   SOLE   0 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 902 130,000 SH   SOLE   0 0 0
ARDELYX INC COM 39697107 5,046 315,955 SH   SOLE   0 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 1,587 191,949 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC COM 42564203 1,221 2,034,721 SH   SOLE   0 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 176 10,000 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 45396108 15,117 784,893 SH   SOLE   0 0 0
AVINGER INC COM 53734109 1,323 102,500 SH   SOLE   0 0 0
BELLICUM PHARMACEUTICALS COM 79481107 11,754 552,628 SH   SOLE   0 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 7,017 470,000 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 10,712 404,404 SH   SOLE   0 0 0
BOVIE MEDICAL CORP COM 10211F100 482 172,700 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 1,444 400,000 SH   SOLE   0 0 0
CIGNA CORPORATION COM 125509109 3,559 21,970 SH   SOLE   0 0 0
CAMBREX CORP COM 132011107 322 7,331 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 15,692 640,500 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 20 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC COM 14149Y108 215 2,574 SH   SOLE   0 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 3,515 851,200 SH   SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 6,549 181,500 SH   SOLE   0 0 0
CELYAD SA ADR 151205200 3,902 75,000 SH   SOLE   0 0 0
CEMPRA INC COM 15130J109 19,671 572,500 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY COM 15870P109 2,235 4,471,180 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 16,998 147,604 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC COM 171757107 4,206 300,000 SH   SOLE   0 0 0
COGENTIX MED INC COM 19243A104 1,091 673,257 SH   SOLE   0 0 0
COHERUS BIOSCIENCES INC COM 19249H103 7,477 258,716 SH   SOLE   0 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 250 3,978 SH   SOLE   0 0 0
CONATUS PHARMACEUTICALS INC COM 20600T108 515 100,000 SH   SOLE   0 0 0
CONMED CORP COM 207410101 498 8,554 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS HOLDINGS INC COM 21833P103 2,679 870,000 SH   SOLE   0 0 0
CREDIT SUISSE NASSAU BRH INVRS VIX STERM 22542D795 162 4,000 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 89 3,002 SH   SOLE   0 0 0
DANAHER CORP DEL COM 235851102 856 10,000 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 24,997 348,784 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 2,668 152,000 SH   SOLE   0 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 698 50,000 SH   SOLE   0 0 0
DIVERSICARE HEALTHCARE SVCS COM 255104101 198 15,337 SH   SOLE   0 0 0
DYAX CORP COM 26746E103 47,337 1,786,315 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 18,844 233,044 SH   SOLE   0 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 223 4,956 SH   SOLE   0 0 0
ENDOLOGIX INC COM 29266S106 4,878 318,000 SH   SOLE   0 0 0
EPIZYME INC COM 29428V104 1,440 60,000 SH   SOLE   0 0 0
ESPERION THERAPEUTICS INC COM 29664W105 16,352 200,000 SH Call SOLE   0 0 0
EVOLENT HEALTH INC CL A 30050B101 2,980 152,800 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 5,567 224,129 SH   SOLE   0 0 0
GALAPAGOS NV SPON ADR 36315X101 1,030 20,000 SH   SOLE   0 0 0
GENVEC INC COM NEW 37246C307 1,256 615,844 SH   SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 23,416 200,000 SH Put SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 288 2,457 SH   SOLE   0 0 0
GREATBATCH INC COM 39153L106 237 4,391 SH   SOLE   0 0 0
HCA HOLDINGS INC COM 40412C101 4,587 50,563 SH   SOLE   0 0 0
HEALTH NET INC COM 42222G108 246 3,831 SH   SOLE   0 0 0
HERON THERAPEUTICS INC COM 427746102 13,960 448,000 SH   SOLE   0 0 0
IGNYTA INC COM 451731103 29,691 1,967,600 SH   SOLE   0 0 0
ILLUMINA INC COM 452327109 5,459 25,000 SH   SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 2,842 700,000 SH Put SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 2,436 600,000 SH   SOLE   0 0 0
IMPRIVATA INC COM 45323J103 982 60,000 SH   SOLE   0 0 0
INC RESH HLDGS INC CL A 45329R109 291 7,261 SH   SOLE   0 0 0
INCYTE CORP COM 45337C102 1,563 15,000 SH   SOLE   0 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 449 41,000 SH   SOLE   0 0 0
INSMED INC COM PAR $.01 457669307 6,980 285,812 SH   SOLE   0 0 0
INTERSECT ENT INC COM 46071F103 293 10,251 SH   SOLE   0 0 0
INVITAE CORP COM 46185L103 2,306 299,583 SH   SOLE   0 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 5,953 493,600 SH   SOLE   0 0 0
ISHARES TR HDG MSCI GERMN 46434V704 2,270 87,000 SH   SOLE   0 0 0
JUNIPER PHARMACEUTICALS INC COM 48203L107 411 44,900 SH   SOLE   0 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 343 34,380 SH   SOLE   0 0 0
LHC GROUP INC COM 50187A107 226 5,917 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 6,199 252,915 SH   SOLE   0 0 0
LEMAITRE VASCULAR INC COM 525558201 239 19,838 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 25,305 2,759,593 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 1,762 336,287 SH   SOLE   0 0 0
MACROGENICS INC COM 556099109 2,894 76,208 SH   SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 203 2,900 SH   SOLE   0 0 0
MCKESSON CORP COM 58155Q103 228 1,015 SH   SOLE   0 0 0
MEDGENICS INC COM NEW 58436Q203 2,852 465,225 SH   SOLE   0 0 0
MERGE HEALTHCARE INC COM 589499102 264 55,015 SH   SOLE   0 0 0
MINVERA NEUROSCIENCES COM 603380106 4,701 810,537 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC COM 60855R100 203 2,888 SH   SOLE   0 0 0
MYRIAD GENETICS INC COM 62855J104 85 2,500 SH   SOLE   0 0 0
NANOSPHERE INC COM NEW 63009F204 115 35,379 SH   SOLE   0 0 0
NEKTAR THERAPEUTICS COM 640268108 4,191 335,000 SH   SOLE   0 0 0
NEOTHETICS INC COM 64066G101 180 20,000 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 8,643 6,700,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 156,866 3,284,467 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 42,944 798,959 SH   SOLE   0 0 0
NOVO-NORDISK A S ADR 670100205 128 2,340 SH   SOLE   0 0 0
ONCOTHYREON INC COM 682324108 12,517 3,346,897 SH   SOLE   0 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 350 70,600 SH   SOLE   0 0 0
OTONOMY INC COM 68906L105 8,446 367,386 SH   SOLE   0 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 4 50 SH   SOLE   0 0 0
PFENEX INC COM 717071104 19,611 1,010,877 SH   SOLE   0 0 0
PHARMERICA CORP COM 71714F104 226 6,800 SH   SOLE   0 0 0
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106 265 6,809 SH   SOLE   0 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 5,061 111,103 SH   SOLE   0 0 0
POWERSHS DB US DOLLAR INDEX DOLL INDX BULL 73936D107 2,253 90,000 SH   SOLE   0 0 0
PROSHARES TR PSHS ULT S&P 500 74347R107 1,936 30,000 SH   SOLE   0 0 0
PROSHARES ULTRA S & P500 PSHS ULT S&P 500 74347R107 3,227 50,000 SH Put SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 4,912 275,000 SH   SOLE   0 0 0
PSIVIDA CORP COM 74440J101 1,187 315,000 SH   SOLE   0 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 11,675 100,000 SH Call SOLE   0 0 0
RADIUS HEALTH INC COM NEW 750469207 15,945 235,530 SH   SOLE   0 0 0
RAPTOR PHARMACEUTICAL CORP COM 75382F106 4,172 264,204 SH   SOLE   0 0 0
RECEPTOS INC COM 756207106 11,587 60,969 SH   SOLE   0 0 0
REGULUS THERAPEUTICS INC COM 75915K101 2,196 200,000 SH Put SOLE   0 0 0
RELYPSA INC COM 759531106 37,694 1,139,142 SH   SOLE   0 0 0
RETROPHIN INC COM 761299106 3,315 100,000 SH Put SOLE   0 0 0
RETROPHIN INC COM 761299106 91,650 2,820,875 SH   SOLE   0 0 0
STREETTRACKS SPDR BIOTEC ETF S&P BIOTECH 78464A870 37,836 150,000 SH Put SOLE   0 0 0
SAGE THERAPEUTICS INC COM 78667J108 1,460 20,000 SH   SOLE   0 0 0
SANGAMO BIOSCIENCES INC COM 800677106 8,872 800,000 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 15,215 500,000 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 85,494 2,809,528 SH   SOLE   0 0 0
SCYNEXIS INC COM 811292101 1,538 175,000 SH   SOLE   0 0 0
SERES THERAPEUTICS INC COM 81750R102 2,075 50,000 SH   SOLE   0 0 0
SHIRE PLC SPONSORED ADR 82481R106 9,660 40,000 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 933 79,245 SH   SOLE   0 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 2,107 700,000 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 331 19,470 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS INC NOTE 7.500% 5/0 868459AB4 7,008 2,187,000 PRN   SOLE   0 0 0
SYNERGETICS USA INC COM 87160G107 208 44,266 SH   SOLE   0 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 492 8,500 SH   SOLE   0 0 0
TESARO INC COM 881569107 49,111 835,359 SH   SOLE   0 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 4,744 100,000 SH   SOLE   0 0 0
THORATEC CORP COM NEW 885175307 4,457 100,000 SH Call SOLE   0 0 0
THORATEC CORP COM NEW 885175307 10,073 226,000 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 6,455 485,338 SH   SOLE   0 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 1,294 100,000 SH   SOLE   0 0 0
TRANSENTERIX INC COM NEW 89366M201 6,132 2,044,032 SH   SOLE   0 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 655 30,000 SH   SOLE   0 0 0
TRIPLE-S MGMT CORP CL B 896749108 272 10,605 SH   SOLE   0 0 0
UNITEDHEALTH GROUP INC COM 91324P102 206 1,685 SH   SOLE   0 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 268 1,883 SH   SOLE   0 0 0
VBI VACCINES INC COM 91790E102 6,813 2,610,365 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 1,887 528,697 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 20,112 1,321,400 SH   SOLE   0 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 2,160 150,000 SH   SOLE   0 0 0
VITAL THERAPIES INC COM 92847R104 6,330 300,000 SH Put SOLE   0 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,980 35,292 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 41,409 1,884,784 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,594 225,000 SH   SOLE   0 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 14,767 135,193 SH   SOLE   0 0 0
ZS PHARMA INC COM 98979G105 18,953 361,777 SH   SOLE   0 0 0
ALLERGAN PLC SHS G0177J108 17,960 59,185 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 3,872 190,000 SH   SOLE   0 0 0
ICON PLC SHS G4705A100 225 3,348 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 8,577 562,436 SH   SOLE   0 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 755 75,000 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 3,070 200,000 SH   SOLE   0 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 215 1,493 SH   SOLE   0 0 0
AFFIMED N V COM N01045108 13,791 1,023,820 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 901 62,000 SH   SOLE   0 0 0
MYLAN N V SHS EURO N59465109 14,599 215,133 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 17,557 650,269 SH   SOLE   0 0 0
PARNELL PHARMACEUT HLDGS LTD SHS Q73622104 341 68,800 SH   SOLE   0 0 0