The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ANI PHARMACEUTICALS INC COM 00182C103 578 12,800 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 7,461 7,500,000 PRN   SOLE   0 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 5,923 1,762,881 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC *W EXP 12/19/201 00289Y115 1,656 1,259,636 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 4225108 8,743 245,240 SH   SOLE   0 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 16 750 SH   SOLE   0 0 0
ACASTI PHARMA INC CL A NEW 00430K402 594 236,559 SH   SOLE   0 0 0
ACCELERON PHARMA INC COM 00434H108 13,460 276,036 SH   SOLE   0 0 0
ACHAOGEN INC COM 4449104 344 60,000 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 23,084 5,995,760 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 3,359 260,000 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 8,410 1,240,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC COM NEW 19621200 4,112 1,921,951 SH   SOLE   0 0 0
ALMOST FAMILY INC COM 20409108 187 4,889 SH   SOLE   0 0 0
AMEDISYS INC COM 23436108 183 4,648 SH   SOLE   0 0 0
AMERISOURCEBERGEN CORP COM 03073E105 211 2,030 SH   SOLE   0 0 0
AMGEN INC COM 31162100 8,117 50,000 SH   SOLE   0 0 0
AMICUS THERAPEUTICS INC COM 03152W109 147,823 15,239,444 SH   SOLE   0 0 0
AMPLIPHI BIOSCIENCES CORP COM NEW 03211P202 298 74,800 SH   SOLE   0 0 0
AMSURG CORP COM 03232P405 170 2,243 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 4,604 992,156 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 17,575 861,513 SH   SOLE   0 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 744 59,600 SH   SOLE   0 0 0
ARDELYX INC COM 39697107 5,725 315,955 SH   SOLE   0 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 313 50,000 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC COM 42564203 1,194 3,463,292 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 45396108 5,970 795,000 SH   SOLE   0 0 0
AVINGER INC COM 53734109 444 19,566 SH   SOLE   0 0 0
BAXTER INTERNATIONAL INC COM 71813109 3,815 100,000 SH Call SOLE   0 0 0
BAXTER INTL INC COM 71813109 18,503 485,000 SH   SOLE   0 0 0
BIOGEN INC COM 09062X103 199 648 SH   SOLE   0 0 0
BELLICUM PHARMACEUTICALS COM 79481107 8,537 421,188 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 10,652 404,404 SH   SOLE   0 0 0
BOVIE MEDICAL CORP COM 10211F100 342 162,700 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E102 1,144 400,000 SH   SOLE   0 0 0
CIGNA CORPORATION COM 125509109 2,927 20,000 SH   SOLE   0 0 0
CAMBREX CORP COM 132011107 221 4,692 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 10,090 483,700 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 12 4,000 SH   SOLE   0 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 2,085 851,200 SH   SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 93 2,996 SH   SOLE   0 0 0
CENTENE CORP DEL COM 15135B101 171 2,593 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1,330 372,597 SH   SOLE   0 0 0
CHARLES RIV LABS INTL INC COM 159864107 274 3,410 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC COM 171757107 12,747 742,858 SH   SOLE   0 0 0
COGENTIX MED INC COM 19243A104 869 673,257 SH   SOLE   0 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 178 6,724 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS INC COM 21833P103 2,062 1,250,000 SH   SOLE   0 0 0
CORVEL CORP COM 221006109 225 5,115 SH   SOLE   0 0 0
CREDIT SUISSE NASSAU BRH INVRS VIX STERM 22542D795 645 25,000 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 13,399 642,047 SH   SOLE   0 0 0
CURIS INC COM 231269101 291 100,000 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 11,137 306,715 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,841 402,884 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 17,374 502,000 SH   SOLE   0 0 0
DEPOMED INC COM 249908104 9,065 500,000 SH   SOLE   0 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 594 50,000 SH   SOLE   0 0 0
DIGIRAD CORP COM 253827109 145 24,988 SH   SOLE   0 0 0
DYAX CORP COM 26746E103 68,439 1,819,215 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 11,806 133,145 SH   SOLE   0 0 0
ENDOLOGIX INC COM 29266S106 2,970 300,000 SH   SOLE   0 0 0
ENSIGN GROUP INC COM 29358P101 198 8,744 SH   SOLE   0 0 0
EVOLENT HEALTH INC CL A 30050B101 1,787 147,600 SH   SOLE   0 0 0
EXACTECH INC COM 30064E109 195 10,734 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 18,016 434,129 SH   SOLE   0 0 0
FLEX PHARMA INC COM 33938A105 3 237 SH   SOLE   0 0 0
FONAR CORP COM NEW 344437405 146 8,473 SH   SOLE   0 0 0
GW PHARMACEUTICALS -ADR ADS 36197T103 27,776 400,000 SH Put SOLE   0 0 0
GENVEC INC COM NEW 37246C307 1,133 615,844 SH   SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 249 2,457 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 38,363 1,186,630 SH   SOLE   0 0 0
GREATBATCH INC COM 39153L106 231 4,391 SH   SOLE   0 0 0
HEALTH NET INC COM 42222G108 262 3,831 SH   SOLE   0 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 14 4,578 SH   SOLE   0 0 0
IGNYTA INC COM 451731103 24,282 1,812,060 SH   SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 614 200,000 SH   SOLE   0 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 157 20,000 SH   SOLE   0 0 0
INOGEN INC COM 45780L104 5 125 SH   SOLE   0 0 0
INVITAE CORP COM 46185L103 1,177 143,366 SH   SOLE   0 0 0
ISHARES TR HDG MSCI GERMN 46434V704 2,437 100,000 SH   SOLE   0 0 0
LHC GROUP INC COM 50187A107 168 3,705 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 17,537 649,515 SH   SOLE   0 0 0
LANNET INC COM 516012101 168 4,182 SH   SOLE   0 0 0
LANTHEUS HLDGS INC COM 516544103 131 38,784 SH   SOLE   0 0 0
LIFEPOINT HEALTH INC COM 53219L109 210 2,862 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 23,161 3,000,161 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,213 336,287 SH   SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 207 3,351 SH   SOLE   0 0 0
MCKESSON CORP COM 58155Q103 233 1,179 SH   SOLE   0 0 0
MEDICINES CO COM 584688105 2,801 75,000 SH   SOLE   0 0 0
MERRIMACK PHARMACEUTICALS IN COM 590328100 395 50,000 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES COM 603380106 4,919 810,537 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC COM 60855R100 168 2,800 SH   SOLE   0 0 0
MYRIAD GENETICS INC COM 62855J104 108 2,500 SH   SOLE   0 0 0
MYOKARDIA INC COM 62857M105 7,372 502,903 SH   SOLE   0 0 0
NANOSPHERE INC COM NEW 63009F204 22 35,379 SH   SOLE   0 0 0
NANTKWEST INC COM 63016Q102 173 10,000 SH   SOLE   0 0 0
NEOS THERAPEUTICS INC COM 64052L106 2,042 142,603 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 7,169 6,700,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 141,208 2,496,167 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 32,694 484,279 SH   SOLE   0 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 968 125,000 SH   SOLE   0 0 0
NOVO-NORDISK A S ADR 670100205 554 9,540 SH   SOLE   0 0 0
ONCOTHYREON INC COM 682324108 7,579 3,414,121 SH   SOLE   0 0 0
OTONOMY INC COM 68906L105 5,716 205,986 SH   SOLE   0 0 0
PFENEX INC COM 717071104 11,896 960,877 SH   SOLE   0 0 0
PHARMERICA CORP COM 71714F104 238 6,800 SH   SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 4,265 275,000 SH   SOLE   0 0 0
PSIVIDA CORP COM 74440J101 2,000 415,000 SH   SOLE   0 0 0
QUINTILES TRANSNATIO HLDGS I COM 74876Y101 185 2,698 SH   SOLE   0 0 0
REGENXBIO INC COM 75901B107 12,934 779,213 SH   SOLE   0 0 0
RETROPHIN INC COM 761299106 49,756 2,579,380 SH   SOLE   0 0 0
SAGE THERAPEUTICS INC COM 78667J108 1,166 20,000 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 19,290 500,000 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 86,455 2,240,928 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 3,858 100,000 SH Put SOLE   0 0 0
SCYNEXIS INC COM 811292101 1,087 175,000 SH   SOLE   0 0 0
SPECTRANETICS CORP COM 84760C107 4,060 269,570 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 496 78,603 SH   SOLE   0 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 13 759 SH   SOLE   0 0 0
SURGICAL CARE AFFILIATES INC COM 86881L106 204 5,133 SH   SOLE   0 0 0
TANDEM DIABETES CARE INC COM 875372104 295 25,000 SH   SOLE   0 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 210 6,927 SH   SOLE   0 0 0
TESARO INC COM 881569107 50,680 968,659 SH   SOLE   0 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 31,573 481,000 SH   SOLE   0 0 0
TITAN PHARMACEUTICALS INC DE COM NEW A 888314309 2,321 522,728 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 4,232 485,338 SH   SOLE   0 0 0
TRANSENTERIX INC COM NEW 89366M201 4,256 1,715,941 SH   SOLE   0 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 378 30,000 SH   SOLE   0 0 0
TRIPLE-S MGMT CORP CL B 896749108 254 10,605 SH   SOLE   0 0 0
UNITEDHEALTH GROUP INC COM 91324P102 193 1,640 SH   SOLE   0 0 0
UTAH MED PRODS INC COM 917488108 107 1,828 SH   SOLE   0 0 0
VCA INC COM 918194101 205 3,731 SH   SOLE   0 0 0
VANDA PHARMACEUTICALS INC COM 921659108 669 71,849 SH   SOLE   0 0 0
VBI VACCINES COM 91790E102 7,955 3,260,356 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 789 305,662 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 28,490 2,299,454 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 13,841 110,000 SH   SOLE   0 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 3,620 200,000 SH   SOLE   0 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 3,005 35,292 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 27,117 1,854,784 SH   SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,655 205,800 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 5,623 558,446 SH   SOLE   0 0 0
ALLERGAN PLC SHS G0177J108 45,313 145,000 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 9,646 535,000 SH   SOLE   0 0 0
ICON PLC SHS G4705A100 172 2,213 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 14,297 893,540 SH   SOLE   0 0 0
ALCOBRA LTD SHS M2239P109 6,458 1,028,272 SH   SOLE   0 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 571 75,000 SH   SOLE   0 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 1,474 275,000 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 4,604 270,000 SH   SOLE   0 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 231 1,493 SH   SOLE   0 0 0
AFFIMED N V COM N01045108 6,186 868,820 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 867 62,000 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 15,996 967,093 SH   SOLE   0 0 0