The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COMMON 002824100 26,588 541,734 SH   SOLE   368,834 0 172,900
ACCELERON PHARMA COMMON 00434H108 20,632 652,084 SH   SOLE   594,684 0 57,400
ACCURAY INC COMMON 004397105 16 2,395 SH   SOLE   2,395 0 0
ACHILLION PHARMACEUTICALS COMMON 00448Q201 872 98,400 SH   SOLE   0 0 98,400
AKORN INC COMMON 009728106 2,943 67,398 SH   SOLE   38,098 0 29,300
ALDER BIOPHARMACEUTICALS COMMON 014339105 36,165 682,736 SH   SOLE   576,736 0 106,000
ALEXION PHARMACEUTICALS INC COMMON 015351109 118,861 657,525 SH   SOLE   570,117 0 87,408
ALIGN TECH INC COMMON 016255101 29,695 473,522 SH   SOLE   319,385 0 154,137
ALKERMES PLC SHARES G01767105 1,861 28,923 SH   SOLE   28,923 0 0
ALLERGAN PLC SHARES G0177J108 48,866 161,031 SH   SOLE   103,069 0 57,962
AMGEN INC COMMON 031162100 86,969 566,497 SH   SOLE   517,446 0 49,051
AMICUS THERAPEUTICS COMMON 03152W109 70,811 5,004,322 SH   SOLE   4,400,522 0 603,800
AMPHASTAR PHARMACEUTICALS SHARES 03209R103 640 36,400 SH   SOLE   0 0 36,400
ASCENDIS PHARMA A S SP ADR 04351P101 4,165 235,560 SH   SOLE   204,460 0 31,100
AURIS MED HLDG AG COMMON H03579101 1,109 228,132 SH   SOLE   228,132 0 0
BAXTER INTL INC COMMON 071813109 22 315 SH   SOLE   315 0 0
BECTON DICKINSON COMMON 075887109 30 210 SH   SOLE   210 0 0
BIOGEN INC COMMON 09062X103 196,893 487,432 SH   SOLE   421,688 0 65,744
BIOMARIN PHARMACEUTICAL INC COMMON 09061G101 132,113 965,877 SH   SOLE   849,274 0 116,603
BOSTON SCIENTIFIC COMMON 101137107 33 1,870 SH   SOLE   1,870 0 0
CAMBREX CORP COMMON 132011107 648 14,744 SH   SOLE   14,744 0 0
CARDIOVASCULAR SYS COMMON 141619106 8 285 SH   SOLE   285 0 0
CATALENT INC COMMON 148806102 526 17,922 SH   SOLE   17,922 0 0
CELGENE CORP COMMON 151020104 145,543 1,257,558 SH   SOLE   1,145,086 0 112,472
CHIMERIX INC COMMON 16934W106 21,940 474,900 SH   SOLE   433,000 0 41,900
CIGNA CORP COMMON 125509109 13,454 83,052 SH   SOLE   83,052 0 0
CLOVIS ONCOLOGY COMMON 189464100 21,702 246,952 SH   SOLE   224,452 0 22,500
COHERUS BIOSCIENCES COMMON 19249H103 462 15,974 SH   SOLE   15,974 0 0
DEPOMED INC COMMON 249908104 1,505 70,114 SH   SOLE   70,114 0 0
DEXCOM INC COMMON 252131107 31,845 398,158 SH   SOLE   266,229 0 131,929
DR REDDYS LABS LTD ADR 256135203 13,704 247,714 SH   SOLE   216,549 0 31,165
EAGLE PHARMACEUTIC COMMON 269796108 2,278 28,169 SH   SOLE   28,169 0 0
EDWARDS LIFESCIENCE COMMON 28176E108 22,194 155,825 SH   SOLE   105,825 0 50,000
ENDO INTL PLC SHARES G30401106 1,893 23,771 SH   SOLE   23,771 0 0
ENTELLUS MED INC COMMON 29363K105 13 505 SH   SOLE   505 0 0
GILEAD SCIENCES INC COMMON 375558103 152,720 1,304,407 SH   SOLE   1,187,491 0 116,916
HALOZYME THERAPEUTIC COMMON 40637H109 78,512 3,477,051 SH   SOLE   3,163,951 0 313,100
HCA HLDGS INC COMMON 40412C101 15,962 175,945 SH   SOLE   140,138 0 35,807
HEARTWARE INTL INC COMMON 422368100 12,981 178,574 SH   SOLE   122,693 0 55,881
HOLOGIC INC COMMON 436440101 9 225 SH   SOLE   225 0 0
HORIZON PHARMA SHARES G4617B105 2,276 65,501 SH   SOLE   65,501 0 0
IMMUNE DESIGN CORP COMMON 45252L103 16,735 810,390 SH   SOLE   740,790 0 69,600
IMPAX LABS INC COMMON 45256B101 2,338 50,915 SH   SOLE   50,915 0 0
INCYTE CORPORATION COMMON 45337C102 94,843 910,114 SH   SOLE   808,004 0 102,110
INTEGRA LIFESCIENCE COMMON 457985208 6 95 SH   SOLE   95 0 0
INTERCEPT PHARMACEUTICALS COMMON 45845P108 42,880 177,647 SH   SOLE   161,647 0 16,000
INTERSECT ENT INC COMMON 46071F103 9 320 SH   SOLE   320 0 0
INTUITIVE SURGICAL INC COMMON 46120E602 17,533 36,188 SH   SOLE   24,730 0 11,458
INVITAE CORP COMMON 46185L103 13,835 929,765 SH   SOLE   846,965 0 82,800
JAZZ PHARMA PLC COMMON G50871105 2,104 11,948 SH   SOLE   11,948 0 0
KARYOPHARM THERAPEUTICS COMMON 48576U106 19,400 712,968 SH   SOLE   648,368 0 64,600
LANNET INC COMMON 516012101 1,938 32,596 SH   SOLE   32,596 0 0
MALLINCKRODT PLC SHARES G5785G107 4,184 35,545 SH   SOLE   17,445 0 18,100
MCKESSON CORP COMMON 58155Q103 2,016 8,968 SH   SOLE   8,968 0 0
MEDTRONIC PLC SHARES G5960L103 38,519 519,829 SH   SOLE   352,482 0 167,347
MERCK & CO INC COMMON 58933Y105 34,946 613,842 SH   SOLE   415,642 0 198,200
MOMENTA PHARMACEUTICALS COMMON 60877T100 2,955 129,542 SH   SOLE   56,342 0 73,200
MYLAN N V SHS EURO N59465109 25,580 376,951 SH   SOLE   261,181 0 115,770
NEKTAR THERAPEUTICS COMMON 640268108 1,249 99,852 SH   SOLE   99,852 0 0
NOVARTIS AG SP ADR 66987V109 16,571 168,505 SH   SOLE   168,505 0 0
NOVO-NORDISK AS ADR 670100205 11,909 217,475 SH   SOLE   217,475 0 0
NXSTAGE MEDICAL COMMON 67072V103 16,745 1,172,196 SH   SOLE   803,040 0 369,156
ONCOMED PHARMACEUTICALS COMMON 68234X102 30,815 1,369,534 SH   SOLE   1,160,523 0 209,011
PACIRA PHARMACEUTICALS COMMON 695127100 1,247 17,632 SH   SOLE   17,632 0 0
PERRIGO CO SHARES G97822103 4,950 26,780 SH   SOLE   13,254 0 13,526
PFIZER INC COMMON 717081103 61,311 1,828,538 SH   SOLE   1,239,459 0 589,079
PORTOLA PHARMACEUTICALS COMMON 737010108 53,254 1,169,130 SH   SOLE   1,062,480 0 106,650
PTC THERAPEUTICS INC COMMON 69366J200 29,588 614,742 SH   SOLE   559,642 0 55,100
REGENERON PHARMACEUTICALS COMMON 75886F107 89,222 174,900 SH   SOLE   159,200 0 15,700
RELYPSA INC COMMON 759531106 27,863 842,030 SH   SOLE   764,330 0 77,700
SAGENT PHARMACEUTICALS COMMON 786692103 11,319 465,625 SH   SOLE   279,942 0 185,683
SEATTLE GENETICS INC COMMON 812578102 61,084 1,262,075 SH   SOLE   1,149,325 0 112,750
SHIRE PLC SP ADR 82481R106 27,484 113,812 SH   SOLE   97,565 0 16,247
SPECTRANETICS CORP COMMON 84760C107 5 230 SH   SOLE   230 0 0
ST JUDE MEDICAL INC COMMON 790849103 22 305 SH   SOLE   305 0 0
STRYKER CORP COMMON 863667101 40 420 SH   SOLE   420 0 0
TANDEM DIABETES CARE COMMON 875372104 7 650 SH   SOLE   650 0 0
TETRAPHASE PHARMACEUTICALS COMMON 88165N105 42,368 893,076 SH   SOLE   761,876 0 131,200
TEVA PHARMACEUTICAL ADR 881624209 21,266 359,832 SH   SOLE   293,930 0 65,902
TG THERAPEUTICS COMMON 88322Q108 12,808 772,017 SH   SOLE   702,617 0 69,400
THERMO FISHER SCIENTIFIC COMMON 883556102 76,563 590,036 SH   SOLE   536,436 0 53,600
THORATEC LABS CORP COMMON 885175307 11 250 SH   SOLE   250 0 0
TORNIER N V SHARES N87237108 10 395 SH   SOLE   395 0 0
UNIQURE N.V. SHARES N90064101 17,545 649,800 SH   SOLE   591,500 0 58,300
UNITED THERAPEUTICS COMMON 91307C102 30,577 175,780 SH   SOLE   159,680 0 16,100
UNIVERSAL HEALTH SVC CLASS B 913903100 9,541 67,146 SH   SOLE   44,376 0 22,770
VALEANT PHARMA INTL COMMON 91911K102 4,461 20,081 SH   SOLE   10,381 0 9,700
VARIAN MED SYS INC COMMON 92220P105 10 115 SH   SOLE   115 0 0
VERTEX PHARMACEUTICALS COMMON 92532F100 73,940 598,800 SH   SOLE   544,700 0 54,100
ZIMMER BIOMET HLDS COMMON 98956P102 27 245 SH   SOLE   245 0 0
ZS PHARMA INC COMMON 98979G105 24,405 465,839 SH   SOLE   423,839 0 42,000