The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA HEALTHCARE COMMON 00404A109 9,922 158,852 SH   SOLE   114,652 0 44,200
ACCELERON PHARMA COMMON 00434H108 54,673 1,121,264 SH   SOLE   968,164 0 153,100
ADEPTUS HEALTH INC CL A 006855100 10,236 187,744 SH   SOLE   135,644 0 52,100
ADVAXIS INC COMMON 007624208 18,015 1,790,715 SH   SOLE   1,621,215 0 169,500
AIMMUNE THERAPEUTICS COMMON 00900T107 18,120 982,133 SH   SOLE   889,633 0 92,500
AKORN INC COMMON 009728106 2,403 64,403 SH   SOLE   24,903 0 39,500
ALDER BIOPHARMACEU COMMON 014339105 30,881 934,951 SH   SOLE   784,051 0 150,900
ALEXION PHARM INC COMMON 015351109 144,623 758,180 SH   SOLE   654,372 0 103,808
ALIGN TECH INC COMMON 016255101 25,425 386,104 SH   SOLE   270,567 0 115,537
ALKERMES PLC SHARES G01767105 2,056 25,895 SH   SOLE   25,895 0 0
ALLERGAN PLC SHARES G0177J108 6,310 20,192 SH   SOLE   6,030 0 14,162
AMGEN INC COMMON 031162100 81,911 504,597 SH   SOLE   455,346 0 49,251
AMICUS THERAPEUTICS COMMON 03152W109 77,342 7,973,436 SH   SOLE   6,824,036 0 1,149,400
AMPHASTAR PHARMACTLS COMMON 03209R103 1,035 72,753 SH   SOLE   37,153 0 35,600
ASCENDIS PHARMA A S SP ADR 04351P101 570 31,100 SH   SOLE   0 0 31,100
BIOGEN INC COMMON 09062X103 89,114 290,889 SH   SOLE   253,045 0 37,844
BIOMARIN PHARMAC INC COMMON 09061G101 142,465 1,359,922 SH   SOLE   1,163,919 0 196,003
CAMBREX CORP COMMON 132011107 1,188 25,231 SH   SOLE   25,231 0 0
CARA THERAPEUTICS COMMON 140755109 20,444 1,212,578 SH   SOLE   1,095,878 0 116,700
CATALENT INC COMMON 148806102 1,533 61,234 SH   SOLE   61,234 0 0
CELGENE CORP COMMON 151020104 140,964 1,177,058 SH   SOLE   1,063,086 0 113,972
CHIMERIX INC COMMON 16934W106 4,923 550,100 SH   SOLE   503,000 0 47,100
CHINA BIOLOGIC PROD COMMON 16938C106 839 5,890 SH   SOLE   5,890 0 0
CIGNA CORP COMMON 125509109 8,356 57,104 SH   SOLE   57,104 0 0
COHERUS BIOSCIENCES COMMON 19249H103 366 15,940 SH   SOLE   15,940 0 0
DEPOMED INC COMMON 249908104 1,689 93,183 SH   SOLE   93,183 0 0
DEXCOM INC COMMON 252131107 29,708 362,733 SH   SOLE   267,504 0 95,229
DR REDDYS LABS LTD ADR 256135203 5,628 121,586 SH   SOLE   82,621 0 38,965
EAGLE PHARMACEUTIC COMMON 269796108 1,942 21,899 SH   SOLE   21,899 0 0
EDWARDS LIFESCIENCE COMMON 28176E108 19,768 250,295 SH   SOLE   171,695 0 78,600
ELI LILLY & CO COMMON 532457108 50,492 599,245 SH   SOLE   432,145 0 167,100
ENDO INTL PLC SHARES G30401106 1,902 31,062 SH   SOLE   31,062 0 0
GILEAD SCIENCES INC COMMON 375558103 180,351 1,782,298 SH   SOLE   1,508,082 0 274,216
HALOZYME THERAPEUTIC COMMON 40637H109 35,974 2,075,796 SH   SOLE   1,814,096 0 261,700
HEARTWARE INTL INC COMMON 422368100 10,282 204,008 SH   SOLE   146,927 0 57,081
IMMUNE DESIGN CORP COMMON 45252L103 17,206 856,867 SH   SOLE   770,767 0 86,100
IMPAX LABS INC COMMON 45256B101 2,011 47,031 SH   SOLE   47,031 0 0
INCYTE CORPORATION COMMON 45337C102 122,269 1,127,423 SH   SOLE   979,423 0 148,000
INTERCEPT PHARMACE COMMON 45845P108 32,864 220,047 SH   SOLE   198,847 0 21,200
INTUITIVE SURGIC INC COMMON 46120E602 16,947 31,030 SH   SOLE   25,972 0 5,058
IONIS PHARMACEUTICAL COMMON 462222100 9,290 150,000 SH   SOLE   150,000 0 0
IRONWOOD PHARMACEUCL COM CL A 46333X108 948 81,762 SH   SOLE   81,762 0 0
JAZZ PHARMA PLC COMMON G50871105 1,905 13,550 SH   SOLE   13,550 0 0
MALLINCKRODT PLC SHARES G5785G107 3,967 53,154 SH   SOLE   28,354 0 24,800
MCKESSON CORP COMMON 58155Q103 2,051 10,401 SH   SOLE   10,401 0 0
MEDTRONIC PLC SHARES G5960L103 41,828 543,792 SH   SOLE   397,345 0 146,447
MERCK & CO INC COMMON 58933Y105 59,260 1,121,925 SH   SOLE   810,825 0 311,100
MOMENTA PHARMACEUTIC COMMON 60877T100 2,845 191,737 SH   SOLE   99,137 0 92,600
MYLAN N V SHS EURO N59465109 32,545 601,910 SH   SOLE   418,240 0 183,670
NEKTAR THERAPEUTICS COMMON 640268108 2,311 137,127 SH   SOLE   137,127 0 0
NEUROCRINE BIOSCIENC COMMON 64125C109 23,572 416,680 SH   SOLE   380,080 0 36,600
NOVARTIS AG SP ADR 66987V109 15,350 178,405 SH   SOLE   178,405 0 0
NOVO-NORDISK AS ADR 670100205 16,093 277,075 SH   SOLE   277,075 0 0
NXSTAGE MEDICAL COMMON 67072V103 15,366 701,303 SH   SOLE   538,847 0 162,456
OPHTHOTECH CORP COMMON 683745103 22,688 288,906 SH   SOLE   260,706 0 28,200
PERRIGO CO SHARES G97822103 4,315 29,821 SH   SOLE   11,795 0 18,026
PROFOUND MEDICAL COMMON 74319B106 594 1,031,700 SH   SOLE   1,031,700 0 0
PRONAI THERAPEUTICS COMMON 74346L101 14,386 910,566 SH   SOLE   845,866 0 64,700
PTC THERAPEUTICS I COMMON 69366J200 51,395 1,586,258 SH   SOLE   1,370,658 0 215,600
REGENERON PHARMCTCLS COMMON 75886F107 128,280 236,300 SH   SOLE   213,400 0 22,900
REGENXBIO INC COMMON 075901B10 3,108 156,741 SH   SOLE   156,741 0 0
REGENXBIO INC COMMON 75901B107 5,822 350,700 SH   SOLE   315,000 0 35,700
SAGENT PHARMACEUTI COMMON 786692103 12,893 810,362 SH   SOLE   518,379 0 291,983
SEATTLE GENETICS INC COMMON 812578102 57,257 1,275,775 SH   SOLE   1,149,325 0 126,450
SHIRE PLC SP ADR 82481R106 33,758 164,674 SH   SOLE   144,427 0 20,247
ST JUDE MEDICAL INC COMMON 790849103 24,533 397,161 SH   SOLE   286,861 0 110,300
TELADOC INC COMMON 87918A105 10,369 577,361 SH   SOLE   432,061 0 145,300
TESARO INC COMMON 881569107 21,193 405,069 SH   SOLE   364,569 0 40,500
TEVA PHARMACEUTICAL ADR 881624209 39,773 605,922 SH   SOLE   535,820 0 70,102
TG THERAPEUTICS COMMON 88322Q108 18,153 1,521,667 SH   SOLE   1,379,267 0 142,400
THERMO FISHER SCI COMMON 883556102 86,094 606,936 SH   SOLE   547,536 0 59,400
UNIQURE N.V. SHARES N90064101 18,831 1,138,513 SH   SOLE   1,041,213 0 97,300
UNITED THERAPEUTICS COMMON 91307C102 30,583 195,280 SH   SOLE   175,480 0 19,800
UNITEDHEALTH GRP INC COMMON 91324P102 24,663 209,648 SH   SOLE   150,148 0 59,500
VERTEX PHARMACEUTICALS COMMON 92532F100 86,596 688,200 SH   SOLE   618,500 0 69,700