The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AEROHIVE NETWORKS INC | COM | 007786106 | 23,922 | 4,681,455 | SH | DFND | 4,681,455 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,303 | 133,488 | SH | DFND | 133,488 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 1,769 | 121,970 | SH | DFND | 121,970 | 0 | 0 | ||
| ARCA BIOPHARMA INC | COM PAR $.001 | 00211Y407 | 6,790 | 1,460,209 | SH | DFND | 1,460,209 | 0 | 0 | ||
| ARDELYX INC | COM | 039697107 | 186,529 | 10,294,096 | SH | DFND | 10,294,096 | 0 | 0 | ||
| ARQULE INC | COM | 04269E107 | 5,469 | 2,520,316 | SH | DFND | 2,520,316 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 6,291 | 2,546,843 | SH | DFND | 2,546,843 | 0 | 0 | ||
| CARE COM INC | COM | 141633107 | 23,349 | 3,260,989 | SH | DFND | 3,260,989 | 0 | 0 | ||
| CATALYST BIOSCIENCES INC | COM | 14888D109 | 2,042 | 652,380 | SH | DFND | 652,380 | 0 | 0 | ||
| CERECOR INC | COM | 15671L109 | 1,195 | 595,435 | SH | DFND | 595,435 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM | 15870P307 | 5,578 | 1,562,500 | SH | DFND | 1,562,500 | 0 | 0 | ||
| CLOVIS ONCOLOGY INC | COM | 189464100 | 39,896 | 1,139,890 | SH | DFND | 1,139,890 | 0 | 0 | ||
| DERMIRA INC | COM | 24983L104 | 121,365 | 3,506,649 | SH | DFND | 3,506,649 | 0 | 0 | ||
| EPIZYME INC | COM | 29428V104 | 82,499 | 5,149,740 | SH | DFND | 5,149,740 | 0 | 0 | ||
| EXELIXIS INC | COM | 30161Q104 | 12,447 | 2,207,000 | SH | DFND | 2,207,000 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 49,101 | 8,584,118 | SH | DFND | 8,584,118 | 0 | 0 | ||
| GROUPON INC | COM CL A | 399473107 | 135,611 | 44,172,953 | SH | DFND | 44,172,953 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM | 528872302 | 31,708 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| LOXO ONCOLOGY INC | COM | 548862101 | 50,988 | 1,792,207 | SH | DFND | 1,792,207 | 0 | 0 | ||
| MIRNA THERAPEUTICS INC | COM | 60470J103 | 18,593 | 2,974,811 | SH | DFND | 2,974,811 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 67,066 | 993,428 | SH | DFND | 993,428 | 0 | 0 | ||
| OPOWER INC | COM | 68375Y109 | 95,011 | 8,997,290 | SH | DFND | 8,997,290 | 0 | 0 | ||
| OREXIGEN THERAPEUTICS INC | COM | 686164104 | 6,379 | 3,709,000 | SH | DFND | 3,709,000 | 0 | 0 | ||
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 2,371 | 125,004 | SH | DFND | 125,004 | 0 | 0 | ||
| RIGEL PHARMACEUTICALS INC | COM | 766559603 | 9,827 | 3,243,150 | SH | DFND | 3,243,150 | 0 | 0 | ||
| ROKA BIOSCIENCE INC | COM | 775431109 | 3,961 | 3,220,433 | SH | DFND | 3,220,433 | 0 | 0 | ||
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 16,274 | 2,141,308 | SH | DFND | 2,141,308 | 0 | 0 | ||
| SUNESIS PHARMACEUTICALS INC | COM | 867328601 | 7,011 | 7,789,644 | SH | DFND | 7,789,644 | 0 | 0 | ||
| TESARO INC | COM | 881569107 | 463,255 | 8,854,255 | SH | DFND | 8,854,255 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H100 | 17,460 | 1,889,652 | SH | DFND | 1,889,652 | 0 | 0 | ||
| TREVENA INC | COM | 89532E109 | 40,023 | 3,811,691 | SH | DFND | 3,811,691 | 0 | 0 | ||
| TRIVASCULAR TECHNOLOGIES INC | COM | 89685A102 | 26,236 | 3,945,191 | SH | DFND | 3,945,191 | 0 | 0 | ||
| ZHONE TECHNOLOGIES INC | COM | 98950P884 | 4,781 | 4,781,290 | SH | DFND | 4,781,290 | 0 | 0 | ||
| ZOSANO PHARMA CORP | COM | 98979H103 | 4,921 | 2,158,543 | SH | DFND | 2,158,543 | 0 | 0 | ||