The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS ADR 00653A107 80,530 9,880,999 SH   DFND   9,880,999 0 0
ACHAOGEN INC COM 004449104 17,870 4,715,128 SH   DFND   4,715,128 0 0
AEROHIVE NETWORKS INC COM 007786106 30,991 4,681,455 SH   DFND   4,681,455 0 0
AGILE THERAPEUTICS PLC COM 00847L100 1,016 133,488 SH   DFND   133,488 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 6,100 452,167 SH   DFND   452,167 0 0
ARCA BIOPHARMA INC COM PAR $.001 00211Y407 4,235 1,460,209 SH   DFND   1,460,209 0 0
ARDELYX INC COM 039697107 102,950 11,792,631 SH   DFND   11,792,631 0 0
ARQULE INC COM 04269E107 4,789 2,520,316 SH   DFND   2,520,316 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 7,055 2,546,843 SH   DFND   2,546,843 0 0
AVEO PHARMACEUTICALS INC COM 053588109 9,948 10,362,694 SH   DFND   10,362,694 0 0
CARE COM INC COM 141633107 38,088 3,260,989 SH   DFND   3,260,989 0 0
CASCADIAN THERAPEUTICS INC COM 14740B101 10,105 10,750,000 SH   DFND   10,750,000 0 0
CATALYST BIOSCIENCES INC COM 14888D109 992 652,380 SH   DFND   652,380 0 0
CERECOR INC COM 15671L109 1,310 595,435 SH   DFND   595,435 0 0
CHAMPIONS ONCOLOGY INC COM 15870P307 3,359 1,562,500 SH   DFND   1,562,500 0 0
CLOVIS ONCOLOGY INC COM 189464100 15,639 1,139,890 SH   DFND   1,139,890 0 0
DERMIRA INC COM 24983L104 102,569 3,506,649 SH   DFND   3,506,649 0 0
ENDOLOGIX INC COM 29266S106 31,028 2,490,204 SH   DFND   2,490,204 0 0
EPIZYME INC COM 29428V104 64,111 6,260,851 SH   DFND   6,260,851 0 0
EXELIXIS INC COM 30161Q104 17,237 2,207,000 SH   DFND   2,207,000 0 0
GLYCOMIMETICS INC COM 38000Q102 62,407 8,584,128 SH   DFND   8,584,128 0 0
GROUPON INC COM CL A 399473107 107,607 33,109,905 SH   DFND   33,109,905 0 0
LEXICON PHARMACEUTICALS INC COM 528872302 34,186 2,382,286 SH   DFND   2,382,286 0 0
LOXO ONCOLOGY INC COM 548862101 41,543 1,792,207 SH   DFND   1,792,207 0 0
MIRNA THERAPEUTICS INC COM 60470J103 12,673 2,974,811 SH   DFND   2,974,811 0 0
NEVRO CORP COM 64157F103 48,713 660,428 SH   DFND   660,428 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 1,595 370,900 SH   DFND   370,900 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 921 66,245 SH   DFND   66,245 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 37,545 3,095,240 SH   DFND   3,095,240 0 0
RIGEL PHARMACEUTICALS INC COM 766559603 7,232 3,243,150 SH   DFND   3,243,150 0 0
ROKA BIOSCIENCE INC COM 775431109 1,836 3,220,433 SH   DFND   3,220,433 0 0
SENSEONICS HOLDINGS INC COM 81727U105 103,372 26,303,189 SH   DFND   26,303,189 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 8,522 2,141,308 SH   DFND   2,141,308 0 0
SUNESIS PHARMACEUTICALS INC COM 867328601 4,284 7,789,644 SH   DFND   7,789,644 0 0
TESARO INC COM 881569107 863,623 10,275,113 SH   DFND   10,275,113 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 8,277 1,889,652 SH   DFND   1,889,652 0 0
TREVENA INC COM 89532E109 24,014 3,811,691 SH   DFND   3,811,691 0 0
ZHONE TECHNOLOGIES INC COM 98950P884 5,690 4,781,290 SH   DFND   4,781,290 0 0
ZOSANO PHARMA CORP COM 98979H103 2,741 2,158,543 SH   DFND   2,158,543 0 0