The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ARCA BIOPHARMA INC COM NEW 00211Y209 6,530 5,678,592 SH   SOLE   5,678,592 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,143 27,300 SH   SOLE   27,300 0 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 88,122 9,945,997 SH   SOLE   9,945,997 0 0
AGENUS INC COM NEW 00847G705 13,808 1,600,000 SH   SOLE   1,600,000 0 0
AGILE THERAPEUTICS INC COM 00847L100 12,531 1,458,792 SH   SOLE   1,458,792 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,100 9,900 SH   SOLE   9,900 0 0
ALCOBRA LTD SHS M2239P109 9,979 1,525,894 SH   SOLE   1,525,894 0 0
ALKERMES PLC SHS G01767105 1,235 19,200 SH   SOLE   19,200 0 0
AMGEN INC COM 031162100 906 5,900 SH   SOLE   5,900 0 0
ARDELYX INC COM 039697107 27,468 1,719,945 SH   SOLE   1,719,945 0 0
ARRAY BIOPHARMA INC COM 04269X105 909 126,095 SH   SOLE   126,095 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 33,825 1,913,153 SH   SOLE   1,913,153 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 3,451 1,142,676 SH   SOLE   1,142,676 0 0
AURIS MED HLDG AG COM H03579101 4,568 940,000 SH   SOLE   940,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 101,900 5,000,000 SH   SOLE   5,000,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 21,832 1,026,402 SH   SOLE   1,026,402 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 38,898 2,605,361 SH   SOLE   2,605,361 0 0
BIOGEN INC COM 09062X103 1,050 2,600 SH   SOLE   2,600 0 0
BIOTA PHARMACEUTIALS INC COM 090694100 1,672 807,855 SH   SOLE   807,855 0 0
BLUEBIRD BIO INC COM 09609G100 18,417 109,383 SH   SOLE   109,383 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 23,267 878,348 SH   SOLE   878,348 0 0
CELGENE CORP COM 151020104 1,007 8,700 SH   SOLE   8,700 0 0
CIDARA THERAPEUTICS INC COM 171757107 16,001 1,141,333 SH   SOLE   1,141,333 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,160 13,200 SH   SOLE   13,200 0 0
COHERUS BIOSCIENCES INC COM 19249H103 39,891 1,380,320 SH   SOLE   1,380,320 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 27,570 1,545,410 SH   SOLE   1,545,410 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 9,953 668,406 SH   SOLE   668,406 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 33,879 2,428,571 SH   SOLE   2,428,571 0 0
DURECT CORP COM 266605104 913 381,800 SH   SOLE   381,800 0 0
DYAX CORP COM 26746E103 71,632 2,703,093 SH   SOLE   2,703,093 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 17,944 766,000 SH   SOLE   766,000 0 0
INCYTE CORP COM 45337C102 1,115 10,700 SH   SOLE   10,700 0 0
JUNO THERAPEUTICS INC COM 48205A109 14,932 280,000 SH   SOLE   280,000 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 591 59,200 SH   SOLE   59,200 0 0
MEDICINES CO COM 584688105 20,197 705,925 SH   SOLE   705,925 0 0
MERRIMACK PHARMACEUTICALS IN COM 590328100 1,439 116,400 SH   SOLE   116,400 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,165 24,400 SH   SOLE   24,400 0 0
NEWLINK GENETICS CORP COM 651511107 1,328 30,000 SH   SOLE   30,000 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 11,473 757,263 SH   SOLE   757,263 0 0
NOVAVAX INC COM 670002104 15,944 1,431,232 SH   SOLE   1,431,232 0 0
OMEROS CORP COM 682143102 13,475 749,000 SH   SOLE   749,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 26,913 1,506,872 SH   SOLE   1,506,872 0 0
PTC THERAPEUTICS INC COM 69366J200 1,242 25,800 SH   SOLE   25,800 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 362 3,100 SH   SOLE   3,100 0 0
REGENERON PHARMACEUTICALS COM 75886F107 1,250 2,450 SH   SOLE   2,450 0 0
REGULUS THERAPEUTICS INC COM 75915K101 41,544 3,790,476 SH   SOLE   3,790,476 0 0
SANGAMO BIOSCIENCES INC COM 800677106 13,532 1,220,209 SH   SOLE   1,220,209 0 0
SANGAMO BIOSCIENCES INC COM 800677106 66,540 6,000,000 SH Call SOLE   0 0 0
SERES THERAPEUTICS INC COM 81750R102 10,236 246,645 SH   SOLE   246,645 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 7,394 450,000 SH   SOLE   450,000 0 0
T2 BIOSYSTEMS INC COM 89853L104 2,240 138,002 SH   SOLE   138,002 0 0
TENAX THERAPEUTICS INC COM 88032L100 9,853 2,670,300 SH   SOLE   2,670,300 0 0
TESARO INC COM 881569107 1,382 23,500 SH   SOLE   23,500 0 0
TG THERAPEUTICS INC COM 88322Q108 54,784 3,302,213 SH   SOLE   3,302,213 0 0
THERAPEUTICSMD INC COM 88338N107 13,208 1,680,395 SH   SOLE   1,680,395 0 0
TREVENA INC COM 89532E109 3,306 528,118 SH   SOLE   528,118 0 0
VICAL INC COM 925602104 1,825 2,606,978 SH   SOLE   2,606,978 0 0
WAFERGEN BIO-SYSTEMS INC COM PAR$ 93041P308 647 205,400 SH   SOLE   205,400 0 0
XENCOR INC COM 98401F105 23,627 1,075,410 SH   SOLE   1,075,410 0 0