The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc | COM | 00448Q201 | 1,136 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
| Acorda Therapeutics Inc | COM | 00484M106 | 5,057 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
| Actinium Pharmaceuticals Inc | COM | 00507W107 | 2,166 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
| Aerie Pharmaceuticals Inc | COM | 00771V108 | 2,725 | 110,000 | SH | DFND | 1,2 | 110,000 | 0 | 0 | |
| Agios Pharmaceuticals Inc | COM | 00847X104 | 1,146 | 25,000 | SH | DFND | 1,2 | 25,000 | 0 | 0 | |
| Akebia Therapeutics Inc | COM | 00972D105 | 2,015 | 72,500 | SH | DFND | 1,2 | 72,500 | 0 | 0 | |
| Allergan Inc/United States | COM | 18490102 | 6,769 | 40,000 | SH | DFND | 1,2 | 40,000 | 0 | 0 | |
| Ambit Biosciences Corp | COM | 02318X100 | 1,918 | 277,568 | SH | DFND | 1,2 | 277,568 | 0 | 0 | |
| Amgen Inc | COM | 31162100 | 4,735 | 40,000 | SH | DFND | 1,2 | 40,000 | 0 | 0 | |
| Amgen Inc | CALL | 31162900 | 1,120 | 1,238 | SH | Call | DFND | 1,2 | 1,238 | 0 | 0 |
| Ampio Pharmaceuticals Inc | COM | 03209T109 | 2,605 | 312,000 | SH | DFND | 1,2 | 312,000 | 0 | 0 | |
| Aquinox Pharmaceuticals Inc | COM | 03842B101 | 1,780 | 190,000 | SH | DFND | 1,2 | 190,000 | 0 | 0 | |
| Array BioPharma Inc | COM | 04269X105 | 1,300 | 285,000 | SH | DFND | 1,2 | 285,000 | 0 | 0 | |
| Arrowhead Research Corp | COM NEW | 42797209 | 1,431 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
| Auxilium Pharmaceuticals Inc | CALL | 05334D907 | 40 | 935 | SH | Call | DFND | 1,2 | 935 | 0 | 0 |
| AVANIR Pharmaceuticals Inc | CL A NEW | 05348P401 | 5,640 | 1,000,000 | SH | DFND | 1,2 | 1,000,000 | 0 | 0 | |
| Biogen Idec Inc | COM | 09062X103 | 6,937 | 22,000 | SH | DFND | 1,2 | 22,000 | 0 | 0 | |
| BioLine RX Ltd | SPONSORED ADR | 09071M106 | 1,248 | 600,000 | SH | DFND | 1,2 | 600,000 | 0 | 0 | |
| BioMarin Pharmaceutical Inc | COM | 09061G101 | 7,465 | 120,000 | SH | DFND | 1,2 | 120,000 | 0 | 0 | |
| Celladon Corp | COM | 15117E107 | 2,403 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
| Clovis Oncology Inc | COM | 189464100 | 4,348 | 105,000 | SH | DFND | 1,2 | 105,000 | 0 | 0 | |
| Corium International Inc | COM | 21887L107 | 537 | 69,100 | SH | DFND | 1,2 | 69,100 | 0 | 0 | |
| Cytokinetics Inc | COM NEW | 23282W605 | 311 | 65,100 | SH | DFND | 1,2 | 65,100 | 0 | 0 | |
| CytRx Corp | COM PAR $.001 | 232828509 | 1,672 | 400,000 | SH | DFND | 1,2 | 400,000 | 0 | 0 | |
| Dipexium Pharmaceuticals Inc | COM | 25456J104 | 916 | 94,400 | SH | DFND | 1,2 | 94,400 | 0 | 0 | |
| Discovery Laboratories Inc | COM NEW | 254668403 | 890 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
| Dyax Corp | COM | 26746E103 | 6,240 | 650,000 | SH | DFND | 1,2 | 650,000 | 0 | 0 | |
| Eli Lilly & Co | COM | 532457108 | 6,217 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
| Epizyme Inc | COM | 29428V104 | 3,522 | 113,188 | SH | DFND | 1,2 | 113,188 | 0 | 0 | |
| Galmed Pharmaceuticals Ltd | SHS | M47238106 | 1,656 | 170,000 | SH | DFND | 1,2 | 170,000 | 0 | 0 | |
| GenVec Inc | COM NEW | 37246C307 | 1,478 | 575,000 | SH | DFND | 1,2 | 575,000 | 0 | 0 | |
| Gilead Sciences Inc | COM | 375558103 | 4,146 | 50,000 | SH | DFND | 1,2 | 50,000 | 0 | 0 | |
| Gilead Sciences Inc | CALL | 375558903 | 1,158 | 1,000 | SH | Call | DFND | 1,2 | 1,000 | 0 | 0 |
| Gilead Sciences Inc | CALL | 375558903 | 850 | 1,000 | SH | Call | DFND | 1,2 | 1,000 | 0 | 0 |
| GlaxoSmithKline PLC | SPONSORED ADR | 37733W105 | 16,044 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
| GlaxoSmithKline PLC | CALL | 37733W905 | 698 | 3,000 | SH | Call | DFND | 1,2 | 3,000 | 0 | 0 |
| Ignyta Inc | COM | 451731103 | 1,863 | 205,000 | SH | DFND | 1,2 | 205,000 | 0 | 0 | |
| Immunomedics Inc | COM | 452907108 | 2,008 | 550,000 | SH | DFND | 1,2 | 550,000 | 0 | 0 | |
| Impax Laboratories Inc | CALL | 45256B901 | 550 | 1,000 | SH | Call | DFND | 1,2 | 1,000 | 0 | 0 |
| Incyte Corp Ltd | COM | 45337C102 | 4,120 | 73,000 | SH | DFND | 1,2 | 73,000 | 0 | 0 | |
| Insmed Inc | COM PAR $.01 | 457669307 | 1,586 | 79,400 | SH | DFND | 1,2 | 79,400 | 0 | 0 | |
| Insmed Inc | CALL | 457669907 | 293 | 1,000 | SH | Call | DFND | 1,2 | 1,000 | 0 | 0 |
| Intra-Cellular Therapies Inc | COM | 46116X101 | 1,590 | 94,300 | SH | DFND | 1,2 | 94,300 | 0 | 0 | |
| Johnson & Johnson | COM | 478160104 | 22,347 | 213,600 | SH | DFND | 1,2 | 213,600 | 0 | 0 | |
| KaloBios Pharmaceuticals Inc | COM | 48344T100 | 821 | 360,000 | SH | DFND | 1,2 | 360,000 | 0 | 0 | |
| MacroGenics Inc | COM | 556099109 | 2,412 | 111,000 | SH | DFND | 1,2 | 111,000 | 0 | 0 | |
| Medivation Inc | COM | 58501N101 | 5,396 | 70,000 | SH | DFND | 1,2 | 70,000 | 0 | 0 | |
| Merck & Co Inc | COM | 58933Y105 | 24,876 | 430,000 | SH | DFND | 1,2 | 430,000 | 0 | 0 | |
| Novartis AG | SPONSORED ADR | 66987V109 | 46,271 | 511,000 | SH | DFND | 1,2 | 511,000 | 0 | 0 | |
| NPS Pharmaceuticals Inc | COM | 62936P103 | 1,619 | 49,000 | SH | DFND | 1,2 | 49,000 | 0 | 0 | |
| Ocera Therapeutics Inc | COM | 67552A108 | 971 | 127,048 | SH | DFND | 1,2 | 127,048 | 0 | 0 | |
| OncoMed Pharmaceuticals Inc | COM | 68234X102 | 1,748 | 75,000 | SH | DFND | 1,2 | 75,000 | 0 | 0 | |
| Oncothyreon Inc | COM | 682324108 | 2,392 | 738,336 | SH | DFND | 1,2 | 738,336 | 0 | 0 | |
| Pfizer Inc | COM | 717081103 | 19,428 | 654,596 | SH | DFND | 1,2 | 654,596 | 0 | 0 | |
| Pharmacyclics Inc | COM | 716933106 | 4,486 | 50,000 | SH | DFND | 1,2 | 50,000 | 0 | 0 | |
| Prosensa Holding BV | SHS USD | N71546100 | 1,578 | 125,000 | SH | DFND | 1,2 | 125,000 | 0 | 0 | |
| PTC Therapeutics Inc | COM | 69366J200 | 3,921 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
| Puma Biotechnology Inc | COM | 74587V107 | 1,650 | 25,000 | SH | DFND | 1,2 | 25,000 | 0 | 0 | |
| Receptos Inc | COM | 756207106 | 2,556 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
| RXi Pharmaceuticals Corp | COM NEW | 74979C303 | 531 | 175,815 | SH | DFND | 1,2 | 175,815 | 0 | 0 | |
| SALIX PHARMACEUTICALS LT | CALL | 795435906 | 915 | 500 | SH | Call | DFND | 1,2 | 500 | 0 | 0 |
| Sanofi | SPONSORED ADR | 80105N105 | 12,746 | 120,000 | SH | DFND | 1,2 | 120,000 | 0 | 0 | |
| Seattle Genetics Inc | COM | 812578102 | 11,391 | 297,800 | SH | DFND | 1,2 | 297,800 | 0 | 0 | |
| Shire PLC | SPONSORED ADR | 82481R106 | 14,065 | 180,000 | SH | DFND | 1,2 | 180,000 | 0 | 0 | |
| StemCells Inc | COM NEW | 85857R204 | 1,015 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
| Summit Corp PLC | COM | 86606G101 | 455 | 777 | SH | DFND | 1,2 | 313,583 | 0 | 0 | |
| TetraLogic Pharmaceuticals Cor | COM | 88165U109 | 1,178 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
| Tetraphase Pharmaceuticals Inc | COM | 88165N105 | 2,671 | 198,000 | SH | DFND | 1,2 | 198,000 | 0 | 0 | |
| Teva Pharmaceutical Industries | ADR | 881624209 | 18,347 | 350,000 | SH | DFND | 1,2 | 350,000 | 0 | 0 | |
| Teva Pharmaceutical Industries | CALL | 881624909 | 970 | 2,000 | SH | Call | DFND | 1,2 | 2,000 | 0 | 0 |
| TG Therapeutics Inc | COM | 88322Q108 | 563 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
| Trevena Inc | COM | 89532E109 | 1,927 | 341,000 | SH | DFND | 1,2 | 341,000 | 0 | 0 | |
| Vanda Pharmaceuticals Inc | COM | 921659108 | 2,265 | 140,000 | SH | DFND | 1,2 | 140,000 | 0 | 0 | |
| Vertex Pharmaceuticals Inc | CALL | 92532F900 | 1,905 | 1,000 | SH | Call | DFND | 1,2 | 1,000 | 0 | 0 |
| Vertex Pharmaceuticals Inc | PUT | 92532F950 | 13 | 1,500 | SH | Put | DFND | 1,2 | 1,500 | 0 | 0 |
| AutoNation Inc | COM | 05329W102 | 3,139 | 52,600 | SH | DFND | 52,600 | 0 | 0 | ||
| B Communications Ltd | SHS | M15629104 | 4,708 | 241,705 | SH | DFND | 241,705 | 0 | 0 | ||
| Broadcom Corp | CL A | 111320107 | 2,937 | 79,120 | SH | DFND | 79,120 | 0 | 0 | ||
| Caesarstone Sdot-Yam Ltd | ORD SHS | M20598104 | 2,925 | 59,600 | SH | DFND | 59,600 | 0 | 0 | ||
| Colgate-Palmolive Co | COM | 194162103 | 3,259 | 47,799 | SH | DFND | 47,799 | 0 | 0 | ||
| CSX Corp | COM | 126408103 | 4,570 | 148,325 | SH | DFND | 148,325 | 0 | 0 | ||
| CVS Caremark Corp | COM | 126650100 | 1,454 | 19,295 | SH | DFND | 19,295 | 0 | 0 | ||
| Ellomay Capital Ltd | SHS | M39927120 | 192 | 20,564 | SH | DFND | 20,564 | 0 | 0 | ||
| Google Inc | CL A | 38259P508 | 2,212 | 3,784 | SH | DFND | 3,784 | 0 | 0 | ||
| Google Inc | CL C | 38259P706 | 2,612 | 4,540 | SH | DFND | 4,540 | 0 | 0 | ||
| Health Care Select Sector SPDR | SBI HEALTHCARE | 81369Y209 | 1,786 | 29,353 | SH | DFND | 29,353 | 0 | 0 | ||
| Lumenis Ltd | SHS CL B | M6778Q121 | 0 | 245 | SH | DFND | 245 | 0 | 0 | ||
| Novartis AG | SPONSORED ADR | 66987V109 | 2,001 | 22,100 | SH | DFND | 22,100 | 0 | 0 | ||
| Orbotech Ltd | ORD | M75253100 | 5,216 | 343,602 | SH | DFND | 343,602 | 0 | 0 | ||
| Ormat Technologies Inc | COM | 686688102 | 677 | 23,472 | SH | DFND | 23,472 | 0 | 0 | ||
| Penske Automotive Group Inc | COM | 70959W103 | 1,452 | 29,327 | SH | DFND | 29,327 | 0 | 0 | ||
| priceline.com Inc | COM NEW | 741503403 | 2,324 | 1,932 | SH | DFND | 1,932 | 0 | 0 | ||
| Sonic Automotive Inc | CL A | 83545G102 | 1,334 | 50,000 | SH | DFND | 50,000 | 0 | 0 | ||
| SPDR S&P 500 ETF Trust | CALL | 78462F903 | 338 | 1,500 | SH | Call | DFND | 1,500 | 0 | 0 | |
| Teva Pharmaceutical Industries | PUT | 881624959 | 80 | 1,000 | SH | Put | DFND | 1,000 | 0 | 0 | |
| Teva Pharmaceutical Industries | CALL | 881624909 | 270 | 1,210 | SH | Call | DFND | 1,210 | 0 | 0 | |
| Teva Pharmaceutical Industries | ADR | 881624209 | 4,954 | 94,500 | SH | DFND | 94,500 | 0 | 0 | ||
| TJX Cos Inc | CALL | 872540909 | 69 | 500 | SH | Call | DFND | 500 | 0 | 0 | |
| TJX Cos Inc | COM | 872540109 | 1,377 | 25,916 | SH | DFND | 25,916 | 0 | 0 | ||
| TOP Image Systems Ltd | ORD | M87896102 | 79 | 20,000 | SH | DFND | 20,000 | 0 | 0 | ||
| Towers Watson & Co | CL A | 891894107 | 4,351 | 41,740 | SH | DFND | 41,740 | 0 | 0 | ||
| Verint Systems Inc | COM | 92343X100 | 6,600 | 134,550 | SH | DFND | 134,550 | 0 | 0 | ||
| Walgreen Co | COM | 931422109 | 4,521 | 60,993 | SH | DFND | 60,993 | 0 | 0 | ||
| Yum! Brands Inc | COM | 988498101 | 4,582 | 56,433 | SH | DFND | 56,433 | 0 | 0 | ||