The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 326 138,105 SH   DFND 1,2 138,105 0 0
ACADIA HEALTHCARE COMPANY IN CALL 00404A909 4,869 1,500 SH Call DFND 1,2 0 0 0
ACHAOGEN INC COM 4449104 4,765 1,257,366 SH   DFND 1,2 1,257,366 0 0
ACORDA THERAPEUTICS INC COM 00484M106 2,499 98,000 SH   DFND 1,2 98,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 4,088 270,000 SH   DFND 1,2 270,000 0 0
ADURO BIOTECH INC COM 00739L101 1,923 170,000 SH   DFND 1,2 170,000 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 4,471 27,662 SH   DFND   27,662 0 0
ALDER BIOPHARMACEUTICALS INC COM 14339105 2,809 112,500 SH   DFND 1,2 112,500 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 2,097 368,500 SH   DFND 1,2 368,500 0 0
ALEXION PHARMACEUTICALS INC COM 15351109 4,942 42,323 SH   DFND 1,2 42,323 0 0
ALLERGAN PLC SHS G0177J108 21,954 95,000 SH   DFND 1,2 95,000 0 0
ALNYLAM PHARMACEUTICALS INC PUT 02043Q957 3,329 600 SH Put DFND 1,2 600 0 0
ALPHABET INC CAP STK CL A 02079K305 2,928 4,162 SH   DFND   4,162 0 0
AMGEN INC COM 31162100 12,933 85,000 SH   DFND 1,2 85,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 5,487 1,005,000 SH   DFND 1,2 1,005,000 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 1,044 300,000 SH   DFND 1,2 300,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,474 261,800 SH   DFND 1,2 261,800 0 0
B COMMUNICATIONS LTD SHS M15629104 3,556 148,861 SH   DFND   148,861 0 0
BIOGEN INC PUT 09062X953 6,046 250 SH Put DFND 1,2 250 0 0
BIOGEN INC COM 09062X103 12,212 50,500 SH   DFND 1,2 50,500 0 0
BLUEBIRD BIO INC COM 09609G100 1,732 40,000 SH   DFND 1,2 40,000 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 752 203,243 SH   DFND 1,2 203,243 0 0
CELGENE CORP COM 151020104 15,288 155,000 SH   DFND 1,2 155,000 0 0
CERULEAN PHARMA INC COM 15708Q105 954 450,000 SH   DFND 1,2 450,000 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 3,673 16,065 SH   DFND   16,065 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 2,103 300,000 SH   DFND 1,2 300,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,744 200,000 SH   DFND 1,2 200,000 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 4,086 500,137 SH   DFND 1,2 500,137 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 4,577 325,053 SH   DFND 1,2 325,053 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 2,245 134,037 SH   DFND 1,2 134,037 0 0
CYTOKINETICS INC COM NEW 23282W605 304 32,069 SH   DFND 1,2 32,069 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 1,977 60,611 SH   DFND 1,2 60,611 0 0
DERMIRA INC COM 24983L104 2,048 70,000 SH   DFND 1,2 70,000 0 0
EDGE THERAPEUTICS INC COM 279870109 1,517 150,000 SH   DFND 1,2 150,000 0 0
EGALET CORP COM 28226B104 1,451 292,500 SH   DFND 1,2 292,500 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,987 150,716 SH   DFND 1,2 150,716 0 0
ELLOMAY CAPITAL LIMITED SHS M39927120 43 5,653 SH   DFND   5,653 0 0
ENDO INTL PLC SHS G30401106 2,339 150,000 SH   DFND 1,2 150,000 0 0
FIBROGEN INC COM 31572Q808 1,406 85,700 SH   DFND 1,2 85,700 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,481 60,000 SH   DFND 1,2 60,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 2,172 342,000 SH   DFND 1,2 342,000 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 2,208 121,500 SH   DFND 1,2 121,500 0 0
GENOCEA BIOSCIENCES INC COM 372427104 2,908 709,271 SH   DFND 1,2 709,271 0 0
GILEAD SCIENCES INC COM 375558103 16,075 192,700 SH   DFND 1,2 192,700 0 0
GILEAD SCIENCES INC CALL 375558903 4,171 500 SH Call DFND 1,2 0 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 6,391 398,287 SH   DFND 1,2 398,287 0 0
GLYCOMIMETICS INC COM 38000Q102 5,220 718,080 SH   DFND 1,2 718,080 0 0
GW PHARMACEUTICALS PLC CALL 36197T903 2,839 310 SH Call DFND 1,2 0 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 3,663 40,000 SH   DFND 1,2 40,000 0 0
HORIZON PHARMA PLC SHS G4617B105 823 50,000 SH   DFND 1,2 50,000 0 0
IMMUNE DESIGN CORP COM 45252L103 1,248 153,000 SH   DFND 1,2 153,000 0 0
IMMUNOMEDICS INC COM 452907108 928 400,000 SH   DFND 1,2 400,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 1,860 250,000 SH   DFND 1,2 250,000 0 0
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 212 16,407 SH   DFND 1,2 16,407 0 0
ISHARES TR PUT 464287955 200 2,000 SH Put DFND   2,000 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 10,448 460,452 SH   DFND   460,452 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 3,726 562,900 SH   DFND 1,2 562,900 0 0
KITE PHARMA INC COM 49803L109 2,500 50,000 SH   DFND 1,2 50,000 0 0
LILLY ELI & CO COM 532457108 15,750 200,000 SH   DFND 1,2 200,000 0 0
MACROGENICS INC COM 556099109 3,509 130,000 SH   DFND 1,2 130,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,487 1,170,643 SH   DFND 1,2 1,170,643 0 0
MEDGENICS INC COM NEW 58436Q203 2,498 450,000 SH   DFND 1,2 450,000 0 0
MERCK & CO INC COM 58933Y105 5,761 100,000 SH   DFND 1,2 100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 819 150,000 SH   DFND 1,2 150,000 0 0
MYLAN N V SHS EURO N59465109 10,810 250,000 SH   DFND 1,2 250,000 0 0
NEURODERM LTD ORD SHS M74231107 4,201 258,513 SH   DFND 1,2 258,513 0 0
ONCOBIOLOGICS INC COM 68235M105 881 259,000 SH   DFND 1,2 259,000 0 0
ORBOTECH LTD ORD M75253100 2,152 84,210 SH   DFND   84,210 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 448 1,015,374 SH   DFND 1,2 1,015,374 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,947 140,000 SH   DFND 1,2 140,000 0 0
PFIZER INC COM 717081103 15,021 426,612 SH   DFND 1,2 426,612 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,304 810,000 SH   DFND 1,2 810,000 0 0
PTC THERAPEUTICS INC COM 69366J200 1,225 174,461 SH   DFND 1,2 174,461 0 0
RADIUS HEALTH INC COM NEW 750469207 3,308 90,000 SH   DFND 1,2 90,000 0 0
RELYPSA INC COM 759531106 2,405 130,000 SH   DFND 1,2 130,000 0 0
RETROPHIN INC COM 761299106 2,672 150,000 SH   DFND 1,2 150,000 0 0
SAGE THERAPEUTICS INC CALL 78667J908 3,013 1,000 SH Call DFND 1,2 0 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,094 69,500 SH   DFND 1,2 69,500 0 0
SAPIENS INTL CORP N V SHS NEW N7716A151 714 60,949 SH   DFND   60,949 0 0
SCYNEXIS INC COM 811292101 279 128,500 SH   DFND 1,2 128,500 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 1,104 27,750 SH   DFND   27,750 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,599 264,539 SH   DFND 1,2 264,539 0 0
SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1,562 197,450 SH   DFND 1,2 197,450 0 0
TESARO INC CALL 881569907 3,782 450 SH Call DFND 1,2 0 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 30,148 600,200 SH   DFND 1,2 600,200 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1,188 132,300 SH   DFND 1,2 132,300 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 5,136 105,000 SH   DFND 1,2 105,000 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 1,380 68,500 SH   DFND 1,2 68,500 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 4,955 57,600 SH   DFND 1,2 57,600 0 0
VISA INC COM CL A 92826C839 2,816 37,966 SH   DFND   37,966 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,147 294,100 SH   DFND 1,2 294,100 0 0