The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abaxis, Inc. Common 002567105 1,157 22,466 SH   SOLE   22,466 0 0
AbbVie Inc. Common 00287Y109 10 156 SH   SOLE   156 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 15,496 370,000 SH   SOLE   370,000 0 0
Accelerate Diagnostics, Inc. Common 00430H102 3,733 144,625 SH   SOLE   144,625 0 0
Achillion Pharmaceuticals Inc Common 00448Q201 4,849 547,300 SH   SOLE   547,300 0 0
Acorda Therapeutics, Inc. Common 00484M106 22,693 680,862 SH   SOLE   680,862 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 504 27,500 SH   SOLE   27,500 0 0
Aegerion Pharmaceuticals, Inc. Common 00767E102 3,908 206,000 SH   SOLE   206,000 0 0
Aetna, Inc. Common 00817Y108 42,308 331,931 SH   SOLE   331,931 0 0
Akorn, Inc. Common 009728106 37,088 849,482 SH   SOLE   849,482 0 0
Alere, Inc. Common 01449J105 15,714 297,901 SH   SOLE   297,901 0 0
Alexion Pharmaceuticals plc Common 015351109 105,625 584,305 SH   SOLE   584,305 0 0
Alkermes plc Shares G01767105 66,622 1,035,470 SH   SOLE   1,035,470 0 0
Allergan plc Shares G0177J108 104,295 343,686 SH   SOLE   343,686 0 0
Allergan plc Preferred Convertible G0177J116 5,213 5,000 SH   SOLE   5,000 0 0
Alliqua BioMedical, Inc. Common 019621200 8,696 1,650,000 SH   SOLE   1,650,000 0 0
Allscripts Healthcare Solutions, Inc. Common 01988P108 24,326 1,778,200 SH   SOLE   1,778,200 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 12,406 103,495 SH   SOLE   103,495 0 0
Amgen Inc. Common 031162100 76,342 497,280 SH   SOLE   497,280 0 0
Amgen Inc. Common 031162100 22,414 146,000 SH Call SOLE   146,000 0 0
Auris Medical Holding AG Common H03579101 10,400 2,105,263 SH   SOLE   2,105,263 0 0
Baxter International, Inc. Common 071813109 22,350 319,600 SH   SOLE   319,600 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 1,276 60,000 SH   SOLE   60,000 0 0
BioDelivery Sciences International, Inc. Common 09060J106 1,990 250,000 SH   SOLE   250,000 0 0
Biogen Inc. Common 09062X103 142,685 353,233 SH   SOLE   353,233 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 73,174 534,977 SH   SOLE   534,977 0 0
bluebird bio, Inc. Common 09609G100 6,885 40,895 SH   SOLE   40,895 0 0
Bristol-Myers Squibb Co. Common 110122108 35,615 535,240 SH   SOLE   535,240 0 0
Catamaran Corporation Common 148887102 26,484 433,600 SH   SOLE   433,600 0 0
Celgene Corporation Common 151020104 223,280 1,929,234 SH   SOLE   1,929,234 0 0
Cellectis S.A. Sponsored ADS 15117K103 1,443 40,000 SH   SOLE   40,000 0 0
Centene Corporation Common 15135B101 9,648 120,000 SH   SOLE   120,000 0 0
Cidara Therapeutics, Inc. Common 171757107 701 50,000 SH   SOLE   50,000 0 0
Cigna Corporation Common 125509109 12,029 74,251 SH   SOLE   74,251 0 0
Community Health Systems, Inc. Common 203668108 13,197 209,572 SH   SOLE   209,572 0 0
Corsicanto Ltd. Note 3.5% 1/15/32 220480AB3 15,803 14,700,000 PRN   SOLE   14,700,000 0 0
Dermira, Inc. Common 24983L104 1,706 97,197 SH   SOLE   97,197 0 0
Endo International PLC Shares G30401106 25,956 325,873 SH   SOLE   325,873 0 0
Endo International PLC Shares G30401106 5,902 74,100 SH Call SOLE   74,100 0 0
Endologix Inc. Common 29266S106 8,452 551,000 SH   SOLE   551,000 0 0
Epizyme, Inc. Common 29428V104 4,800 200,000 SH   SOLE   200,000 0 0
Esperion Therapeutics, Inc. Common 29664W105 12,100 148,000 SH   SOLE   148,000 0 0
Esperion Therapeutics, Inc. Common 29664W105 12,100 148,000 SH Call SOLE   148,000 0 0
Flex Pharma, Inc. Common 33938A105 4,001 232,600 SH   SOLE   232,600 0 0
Foamix Pharmaceuticals Ltd. Shares M46135105 4,241 413,800 SH   SOLE   413,800 0 0
Galapagos NV Sponsored ADR 36315X101 1,030 20,000 SH   SOLE   20,000 0 0
GenMark Diagnostics, Inc. Common 372309104 1,949 215,149 SH   SOLE   215,149 0 0
Gilead Sciences, Inc. Common 375558103 243,495 2,079,731 SH   SOLE   2,079,731 0 0
HCA Holdings, Inc. Common 40412C101 19,395 213,788 SH   SOLE   213,788 0 0
HCA Holdings, Inc. Common 40412C101 6,015 66,300 SH Call SOLE   66,300 0 0
Health Care REIT Inc. Common 42217K601 11,888 200,000 SH   SOLE   200,000 0 0
Heron Therapeutics, Inc. Common 427746102 13,616 436,970 SH   SOLE   436,970 0 0
Humana, Inc. Common 444859102 21,423 112,000 SH   SOLE   112,000 0 0
IDEXX Laboratories, Inc. Common 45168D104 8,489 132,352 SH   SOLE   132,352 0 0
Illumina, Inc. Common 452327109 50,144 229,641 SH   SOLE   229,641 0 0
Impax Laboratories, Inc. Common 45256B101 15,828 344,683 SH   SOLE   344,683 0 0
Incyte Corporation Common 45337C102 91,753 880,461 SH   SOLE   880,461 0 0
IntelliPharmaceutics International Inc. Common 458173101 1,041 354,047 SH   SOLE   354,047 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 7,258 227,164 SH   SOLE   227,164 0 0
Ironwood Pharmaceuticals, Inc. Common 46333X108 9,263 768,050 SH   SOLE   768,050 0 0
Ishares Nasdaq Biotechnology ETF ETF 464287556 21,278 57,670 SH   SOLE   57,670 0 0
Isis Pharmaceuticals, Inc. Common 464330109 5,651 98,200 SH   SOLE   98,200 0 0
Isis Pharmaceuticals, Inc. Common 464330109 5,651 98,200 SH Call SOLE   98,200 0 0
Jazz Pharmaceuticals plc Shares G50871105 21,191 120,357 SH   SOLE   120,357 0 0
Johnson & Johnson Common 478160104 86,214 884,612 SH   SOLE   884,612 0 0
Karyopharm Therapeutics Inc. Common 48576U106 12,978 476,966 SH   SOLE   476,966 0 0
Kite Pharma, Inc. Common 49803L109 384 6,300 SH   SOLE   6,300 0 0
KYTHERA Biopharmaceuticals Inc. Common 501570105 4,196 55,717 SH   SOLE   55,717 0 0
LTC Properties Inc. Common 502175102 9,843 236,618 SH   SOLE   236,618 0 0
MacroGenics, Inc. Common 556099109 484 12,743 SH   SOLE   12,743 0 0
McKesson Corporation Common 58155Q103 15,256 67,862 SH   SOLE   67,862 0 0
Medical Properties Trust Inc. Common 58463J304 15,123 1,153,574 SH   SOLE   1,153,574 0 0
Medivation, Inc Common 58501N101 6,133 53,700 SH   SOLE   53,700 0 0
Medivation, Inc Common 58501N101 6,133 53,700 SH Call SOLE   53,700 0 0
Merck & Co., Inc. Common 58933Y105 10,532 185,000 SH   SOLE   185,000 0 0
Merrimack Pharmaceuticals, Inc. Note 4.50% 7/15/20 590328AA8 3,113 1,485,000 PRN   SOLE   1,485,000 0 0
Merrimack Pharmaceuticals, Inc. Common 590328100 7,021 567,787 SH   SOLE   567,787 0 0
Molina Healthcare, Inc. Common 60855R100 24,457 347,901 SH   SOLE   347,901 0 0
Mylan NV Shares Euro N59465109 124,659 1,837,005 SH   SOLE   1,837,005 0 0
Mylan NV Shares Euro N59465109 11,699 172,400 SH Call SOLE   172,400 0 0
Myriad Genetics, Inc. Common 62855J104 2,542 74,800 SH   SOLE   74,800 0 0
Neurocrine Biosciences, Inc. Common 64125C109 17,951 375,860 SH   SOLE   375,860 0 0
Omega Healthcare Investors Inc. Common 681936100 14,182 413,116 SH   SOLE   413,116 0 0
OncoGenex Pharmaceuticals, Inc. Common 68230A106 264 113,100 SH   SOLE   113,100 0 0
Paratek Pharmaceuticals, Inc. Common 699374302 17,807 691,000 SH   SOLE   691,000 0 0
Pfizer, Inc. Common 717081103 54,930 1,638,241 SH   SOLE   1,638,241 0 0
Physicians Realty Trust Common 71943U104 16,142 1,050,902 SH   SOLE   1,050,902 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 10,583 3,848,191 SH   SOLE   3,848,191 0 0
Receptos, Inc. Common 756207106 23,718 124,800 SH   SOLE   124,800 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 95,479 187,166 SH   SOLE   187,166 0 0
Sabra Health Care REIT Inc. Common 78573L106 11,742 456,190 SH   SOLE   456,190 0 0
Sage Therapeutics, Inc. Common 78667J108 1,095 15,000 SH   SOLE   15,000 0 0
Sagent Pharmaceuticals, Inc. Common 786692103 9,955 409,500 SH   SOLE   409,500 0 0
Sangamo BioSciences, Inc. Common 800677106 832 75,000 SH   SOLE   75,000 0 0
Senior Housing Properties Trust Shares 81721M109 8,417 479,604 SH   SOLE   479,604 0 0
Spectrum Pharmaceuticals, Inc. Note 2.75% 12/15/18 84763AAB4 4,694 5,000,000 PRN   SOLE   5,000,000 0 0
St Jude Medical, Inc. Common 790849103 11,802 161,510 SH   SOLE   161,510 0 0
Stryker Corporation Common 863667101 11,845 123,940 SH   SOLE   123,940 0 0
Supernus Pharmaceuticals, Inc. Note 7.50% 5/1/19 868459AB4 6,655 2,000,000 PRN   SOLE   2,000,000 0 0
Tenet Healthcare Corporation Common 88033G407 9,521 164,500 SH   SOLE   164,500 0 0
Tenet Healthcare Corporation Common 88033G407 6,077 105,000 SH Call SOLE   105,000 0 0
TetraLogic Pharmaceuticals Corporation Note 8.00% 6/15/19 88165UAB5 2,658 4,500,000 PRN   SOLE   4,500,000 0 0
Teva Pharmaceutical Industries Ltd. ADR 881624209 82,007 1,387,594 SH   SOLE   1,387,594 0 0
TherapeuticsMD, Inc. Common 88338N107 11,645 1,481,500 SH   SOLE   1,481,500 0 0
Thermo Fisher Scientific Inc. Common 883556102 11,211 86,395 SH   SOLE   86,395 0 0
Trillium Therapeutics Inc. Common 89620X506 1,418 65,000 SH   SOLE   65,000 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 6,143 60,000 SH   SOLE   60,000 0 0
Ventas Inc. Common 92276F100 18,179 292,782 SH   SOLE   292,782 0 0
Verastem, Inc. Common 92337C104 9,424 1,249,827 SH   SOLE   1,249,827 0 0
Vertex Pharmaceuticals, Inc. Common 92532F100 110,873 897,903 SH   SOLE   897,903 0 0
WellCare Health Plans Inc. Common 94946T106 7,520 88,652 SH   SOLE   88,652 0 0
Wright Medical Group Inc. Common 98235T107 4,099 156,100 SH   SOLE   156,100 0 0
Xencor, Inc. Common 98401F105 439 20,000 SH   SOLE   20,000 0 0
Zafgen, Inc. Common 98885E103 461 13,307 SH   SOLE   13,307 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 11,174 102,300 SH   SOLE   102,300 0 0
Zogenix, Inc. Common 98978L105 6,385 3,800,811 SH   SOLE   3,800,811 0 0