The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 6,343 116,581 SH   SOLE 116,581 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 736 181,818 SH   SOLE 181,818 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 3,319 480,300 SH   SOLE 480,300 0 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 159 90,000 SH   SOLE 90,000 0 0
ADVAXIS INC COM NEW 007624208 51 5,000 SH   SOLE 5,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,939 165,669 SH   SOLE 165,669 0 0
AKARI THERAPEUTICS PLC ADR ADDED 00972G108 633 26,390 SH   SOLE 26,390 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 590 18,000 SH   SOLE 18,000 0 0
AMGEN INC COM 031162100 512 3,700 SH   SOLE 3,700 0 0
ANTARES PHARMA INC COM 036642106 77 45,000 SH   SOLE 45,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,066 157,192 SH   SOLE 157,192 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 83 19,239 SH   SOLE 19,239 0 0
ARENA PHARMACEUTICALS INC COM 040047102 729 381,600 SH   SOLE 381,600 0 0
ASCENDIS PHARMA ADR 04351P101 942 53,241 SH   SOLE 53,241 0 0
ATRICURE INC COM 04963C209 10,691 487,946 SH   SOLE 487,946 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 1,159 140,600 SH   SOLE 140,600 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,949 258,642 SH   SOLE 258,642 0 0
BIOTELEMETRY INC COM 090672106 2,884 235,645 SH   SOLE 235,645 0 0
BLUEBIRD BIO INC COM 09609G100 513 6,000 SH   SOLE 6,000 0 0
CARA THERAPEUTICS INC COM 140755109 1,337 93,574 SH   SOLE 93,574 0 0
CARDICA INC COM 14141R101 379 1,402,762 SH   SOLE 1,402,762 0 0
CAREDX INC COM 14167L103 567 135,927 SH   SOLE 135,927 0 0
CAS MEDICAL SYSTEMS INC COM PAR $0.004 124769209 108 86,768 SH   SOLE 86,768 0 0
CATALYST BIOSCIENCES INC COM ADDED 14888D109 330 70,903 SH   SOLE 70,903 0 0
CEL SCI CORP COM PAR $0.01 150837508 84 139,500 SH   SOLE 139,500 0 0
CELGENE CORP COM 151020104 562 5,200 SH   SOLE 5,200 0 0
CELYAD ADR 151205200 1,256 30,000 SH   SOLE 30,000 0 0
CHECK CAP LTD SHS M2361E112 307 109,900 SH   SOLE 109,900 0 0
CHECK CAP LTD *W EXP 02/28/202 M2361E120 28 55,000 SH   SOLE 55,000 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 88 21,722 SH   SOLE 21,722 0 0
COGENTIX MEDICAL INC COM 19243A104 436 351,781 SH   SOLE 351,781 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 79 50,000 SH   SOLE 50,000 0 0
CYNAPSUS THERAPEUTICS INC COM 23257Y156 536 33,995 SH   SOLE 33,995 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 707 44,824 SH   SOLE 44,824 0 0
CYTRX CORP COM PAR $.001 232828509 1,382 583,013 SH   SOLE 583,013 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,681 356,918 SH   SOLE 356,918 0 0
DERMIRA INC COM 24983L104 525 22,500 SH   SOLE 22,500 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,014 123,500 SH   SOLE 123,500 0 0
DISCOVERY LABORATORIES INC COM NEW 254668403 2,253 7,508,544 SH   SOLE 7,508,544 0 0
ENTEROMEDICS INC COM NEW 29365M208 130 500,000 SH   SOLE 500,000 0 0
ESSA PHARMA INC COM 29668H104 1,424 228,500 SH   SOLE 228,500 0 0
EXACTECH INC COM 30064E109 551 31,636 SH   SOLE 31,636 0 0
GALAPAGOS NV-SPON ADR ADR 36315X101 70 1,709 SH   SOLE 1,709 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 44 5,871 SH   SOLE 5,871 0 0
GENVEC INC COM NEW 37246C307 221 95,800 SH   SOLE 95,800 0 0
GILEAD SCIENCES INC COM 375558103 560 5,700 SH   SOLE 5,700 0 0
INSULET CORP COM 45784P101 2,747 106,018 SH   SOLE 106,018 0 0
INSULET CORP NOTE 2.000% 6/1 45784PAD3 2,229 2,407,000 PRN   SOLE 2,407,000 0 0
INTEC PHARMA LTD SHS ADDED M53644106 756 135,000 SH   SOLE 135,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 403 2,430 SH   SOLE 2,430 0 0
IRONWOOD PHARMA NOTE 2.25% 15-Jun-2022 144A SR UNSECURED CONV 46333XAC2 537 600,000 PRN   SOLE 600,000 0 0
JOHNSON AND JOHNSON COM 478160104 877 9,400 SH   SOLE 9,400 0 0
LIPOCINE INC COM NEW 53630X104 532 45,000 SH   SOLE 45,000 0 0
LOXO ONCOLOGY INC COM 548862101 205 11,745 SH   SOLE 11,745 0 0
LUMENIS LTD SHS CL B M6778Q121 430 31,072 SH   SOLE 31,072 0 0
MACROGENICS INC COM 556099109 514 24,000 SH   SOLE 24,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 186 22,319 SH   SOLE 22,319 0 0
MASIMO CORPORATION COM 574795100 1,774 46,010 SH   SOLE 46,010 0 0
NEOS THERAPEUTICS INC COM ADDED 64052L106 1,332 63,400 SH   SOLE 63,400 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 195 15,000 SH   SOLE 15,000 0 0
NOVADAQ TECHNOLOGIES INC COM 66987G102 1,062 101,841 SH   SOLE 101,841 0 0
NUVASIVE INC NOTE 2.750% 7/0 670704AC9 959 760,000 PRN   SOLE 760,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 5,781 366,554 SH   SOLE 366,554 0 0
ONCOTHYREON INC COM 682324108 99 36,180 SH   SOLE 36,180 0 0
OTONOMY INC COM 68906L105 1,985 111,466 SH   SOLE 111,466 0 0
PRONAI THERAPEUTICS INC COM ADDED 74346L101 174 8,500 SH   SOLE 8,500 0 0
PROTALIX BIOTHERAPEUTICS INC COM 74365A101 1,408 1,193,189 SH   SOLE 1,193,189 0 0
PROTALIX BIOTHERAPEUTICS INC NOTE 4.500% 9/1 74365AAB7 2,698 4,000,000 PRN   SOLE 4,000,000 0 0
REGULUS THERAPEUTICS INC COM 75915K101 589 90,000 SH   SOLE 90,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,741 1,109,740 SH   SOLE 1,109,740 0 0
SCYNEXIS INC COM 811292101 1,142 156,904 SH   SOLE 156,904 0 0
SPECTRANETICS CORP COM 84760C107 941 79,812 SH   SOLE 79,812 0 0
STEREOTAXIS INC COM NEW 85916J409 1,274 1,372,862 SH   SOLE 1,372,862 0 0
SYNERGY PHARMACEUTICALS COM 871639308 1,572 296,563 SH   SOLE 296,563 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 615 85,947 SH   SOLE 85,947 0 0
TANDEM DIABETES CARE INC COM 875372104 322 36,551 SH   SOLE 36,551 0 0
TARGACEPT INC NOTE 0.0% 19-Feb-2018 UNSECURED CONV 87611RAA6 531 530,821 PRN   SOLE 530,821 0 0
TENAX THERAPEUTICS INC COM 88032L100 245 81,509 SH   SOLE 81,509 0 0
TOBIRA THERAPEUTICS INC COM 88883P101 436 45,092 SH   SOLE 45,092 0 0
TREVENA INC COM 89532E109 153 14,800 SH   SOLE 14,800 0 0
UNIQURE B.V. NV SHS N90064101 716 35,000 SH   SOLE 35,000 0 0
VENAXIS INC COM 92262A107 200 650,400 SH   SOLE 650,400 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 780 70,885 SH   SOLE 70,885 0 0
VTV THERAPEUTICS INC- CL A CL A ADDED 918385105 489 75,000 SH   SOLE 75,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 207 25,000 SH   SOLE 25,000 0 0
XENOPORT INC COM 98411C100 1,633 470,612 SH   SOLE 470,612 0 0
ZOGENIX INC COM 98978L204 930 68,900 SH   SOLE 68,900 0 0
ZS PHARMA INC COM 98979G105 4,346 66,194 SH   SOLE 66,194 0 0