The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 59,040 953,642 SH   DFND   0 953,642 0
ABBVIE INC COM 00287Y109 5,634 99,864 SH   DFND   0 99,864 0
ABBVIE INC COM 00287Y109 1,474 26,120 SH   DFND   0 26,120 0
ACCURAY INC COM 004397105 30,002 5,780,693 SH   DFND   0 5,780,693 0
AERIE PHARMACEUTICALS INC COM 00771V108 41,213 2,341,640 SH   DFND   0 2,341,640 0
AETNA INC NEW COM 00817Y108 112,204 918,724 SH   DFND   0 918,724 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 97,363 3,899,209 SH   DFND   0 3,899,209 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 26,303 330,735 SH   DFND   0 330,735 0
AMAZON COM INC COM 023135106 64,137 89,624 SH   DFND   0 89,624 0
AMERICAN RENAL ASSOCIATES HO COM 029227105 1,519 52,427 SH   DFND   0 52,427 0
ANTERO RES CORP COM 03674X106 45,556 1,753,495 SH   DFND   0 1,753,495 0
APPLE INC COM 037833100 12,491 130,660 SH   DFND   0 130,660 0
APPLIED MATLS INC CALL 038222905 57,751 2,409,300 SH Call DFND   0 2,409,300 0
APPLIED MATLS INC COM 038222105 90,546 3,777,487 SH   DFND   0 3,777,487 0
BAXTER INTL INC COM 071813109 61,343 1,356,543 SH   DFND   0 1,356,543 0
BECTON DICKINSON & CO COM 075887109 39,545 233,182 SH   DFND   0 233,182 0
BIOGEN INC COM 09062X103 81,080 335,290 SH   DFND   0 335,290 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 44,432 571,104 SH   DFND   0 571,104 0
BLUEPRINT MEDICINES CORP COM 09627Y109 33,342 1,646,516 SH   DFND   0 1,646,516 0
BRISTOL MYERS SQUIBB CO CALL 110122908 134,619 1,830,300 SH Call DFND   0 1,830,300 0
BRISTOL MYERS SQUIBB CO COM 110122108 38,226 519,722 SH   DFND   0 519,722 0
BROOKDALE SR LIVING INC COM 112463104 49,184 3,185,477 SH   DFND   0 3,185,477 0
CBRE GROUP INC CL A 12504L109 46,681 1,762,886 SH   DFND   0 1,762,886 0
CIRRUS LOGIC INC COM 172755100 52,990 1,366,079 SH   DFND   0 1,366,079 0
CLOVIS ONCOLOGY INC COM 189464100 27,256 1,986,582 SH   DFND   0 1,986,582 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 67,474 94,784,000 PRN   DFND   0 94,784,000 0
COMMSCOPE HLDG CO INC COM 20337X109 48,056 1,548,706 SH   DFND   0 1,548,706 0
DEVON ENERGY CORP NEW COM 25179M103 27,341 754,242 SH   DFND   0 754,242 0
DIMENSION THERAPEUTICS INC COM 25433V105 3,996 666,070 SH   DFND   0 666,070 0
DISH NETWORK CORP CL A 25470M109 62,814 1,198,731 SH   DFND   0 1,198,731 0
EDWARDS LIFESCIENCES CORP COM 28176E108 109,873 1,101,701 SH   DFND   0 1,101,701 0
ENDOLOGIX INC COM 29266S106 19,424 1,558,942 SH   DFND   0 1,558,942 0
FACEBOOK INC CL A 30303M102 92,016 805,179 SH   DFND   0 805,179 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 17,069 1,028,867 SH   DFND   0 1,028,867 0
GW PHARMACEUTICALS PLC PUT 36197T953 15,475 169,000 SH Put DFND   0 169,000 0
HALLIBURTON CO COM 406216101 40,442 892,964 SH   DFND   0 892,964 0
HCA HOLDINGS INC COM 40412C101 49,508 642,873 SH   DFND   0 642,873 0
HERBALIFE LTD NOTE 2.000% 8/1 42703MAB9 61,227 61,767,000 PRN   DFND   0 61,767,000 0
HERBALIFE LTD COM USD SHS G4412G101 45,282 773,654 SH   DFND   0 773,654 0
HERON THERAPEUTICS INC COM 427746102 60,487 3,351,104 SH   DFND   0 3,351,104 0
HOLOGIC INC COM 436440101 40,667 1,175,350 SH   DFND   0 1,175,350 0
HORTONWORKS INC COM 440894103 12,533 1,172,433 SH   DFND   0 1,172,433 0
INNOVIVA INC COM 45781M101 1,410 133,897 SH   DFND   0 133,897 0
INSYS THERAPEUTICS INC NEW PUT 45824V959 672 51,900 SH Put DFND   0 51,900 0
ISHARES TR PUT 464287956 28,153 109,400 SH Put DFND   0 109,400 0
JAZZ PHARMACEUTICALS PLC CALL G50871905 28,926 204,700 SH Call DFND   0 204,700 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 72,065 509,981 SH   DFND   0 509,981 0
KITE PHARMA INC COM 49803L109 15,588 311,765 SH   DFND   0 311,765 0
KURA ONCOLOGY INC COM 50127T109 4,529 1,671,164 SH   DFND   0 1,671,164 0
LILLY ELI & CO PUT 532457958 32,996 419,000 SH Put DFND   0 419,000 0
LILLY ELI & CO PUT 532457958 52,818 670,700 SH Put DFND   0 670,700 0
LIVANOVA PLC SHS G5509L101 12,299 244,851 SH   DFND   0 244,851 0
MCKESSON CORP COM 58155Q103 52,493 281,238 SH   DFND   0 281,238 0
MEDICINES CO COM 584688105 88,069 2,618,754 SH   DFND   0 2,618,754 0
MEDICINES CO NOTE 2.500% 1/1 584688AE5 7,295 6,166,000 PRN   DFND   0 6,166,000 0
MERCK & CO INC PUT 58933Y955 137,809 2,392,100 SH Put DFND   0 2,392,100 0
MICROSOFT CORP COM 594918104 52,529 1,026,566 SH   DFND   0 1,026,566 0
MOLINA HEALTHCARE INC COM 60855R100 15,742 315,479 SH   DFND   0 315,479 0
MYOKARDIA INC COM 62857M105 10,401 838,810 SH   DFND   0 838,810 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 5,766 16,072,000 PRN   DFND   0 16,072,000 0
PALO ALTO NETWORKS INC COM 697435105 39,397 321,244 SH   DFND   0 321,244 0
PENUMBRA INC COM 70975L107 2,272 38,186 SH   DFND   0 38,186 0
POWERSHARES QQQ TRUST CALL 73935A904 56,738 527,600 SH Call DFND   0 527,600 0
PUMA BIOTECHNOLOGY INC COM 74587V107 43,847 1,471,879 SH   DFND   0 1,471,879 0
REGENERON PHARMACEUTICALS PUT 75886F957 34,364 98,400 SH Put DFND   0 98,400 0
RICE ENERGY INC COM 762760106 19,066 865,063 SH   DFND   0 865,063 0
SELECT SECTOR SPDR TR CALL 81369Y906 43,073 631,200 SH Call DFND   0 631,200 0
SELECT SECTOR SPDR TR PUT 81369Y959 74,279 1,035,900 SH Put DFND   0 1,035,900 0
SPECTRANETICS CORP COM 84760C107 4,828 258,019 SH   DFND   0 258,019 0
TENET HEALTHCARE CORP COM NEW 88033G407 19,112 691,461 SH   DFND   0 691,461 0
U S SILICA HLDGS INC COM 90346E103 13,179 382,341 SH   DFND   0 382,341 0
UNITEDHEALTH GROUP INC COM 91324P102 51,827 367,047 SH   DFND   0 367,047 0
UNIVERSAL HLTH SVCS INC CL B 913903100 33,459 249,510 SH   DFND   0 249,510 0
VERTEX PHARMACEUTICALS INC COM 92532F100 11,655 135,487 SH   DFND   0 135,487 0
VIPSHOP HLDGS LTD SPONSORED ADR 92763W103 16,317 1,460,749 SH   DFND   0 1,460,749 0
VIPSHOP HLDGS LTD NOTE 1.500% 3/1 92763WAA1 65,064 65,888,000 PRN   DFND   0 65,888,000 0
VISA INC COM CL A 92826C839 17,495 235,872 SH   DFND   0 235,872 0
VOYAGER THERAPEUTICS INC COM 92915B106 14,679 1,335,671 SH   DFND   0 1,335,671 0
VULCAN MATLS CO COM 929160109 20,823 173,008 SH   DFND   0 173,008 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 69,296 832,187 SH   DFND   0 832,187 0
ZELTIQ AESTHETICS INC COM 98933Q108 16,517 604,342 SH   DFND   0 604,342 0