The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 37,482 953,500 SH   SOLE   953,500 0 0
Abbott Laboratories Common 002824100 4,866 123,800 SH Call SOLE   247,600 0 0
AbbVie Inc. Common 00287Y109 10 156 SH   SOLE   156 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 11,802 363,585 SH   SOLE   363,585 0 0
Accelerate Diagnostics, Inc. Common 00430H102 3,808 264,625 SH   SOLE   264,625 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 2,420 296,934 SH   SOLE   296,934 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 7,410 13,000,000 PRN   SOLE   13,000,000 0 0
Affimed NV Common N01045108 730 294,213 SH   SOLE   294,213 0 0
Agilent Technologies, Inc. Common 00846U101 21,978 495,450 SH   SOLE   495,450 0 0
Akorn, Inc. Common 009728106 6,986 245,235 SH   SOLE   245,235 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 79,608 681,805 SH   SOLE   681,805 0 0
Alkermes plc Shares G01767105 29,988 693,844 SH   SOLE   693,844 0 0
Alkermes plc Common G01767105 4,836 111,900 SH Call SOLE   111,900 0 0
Allergan plc Common G0177J108 107,199 463,886 SH   SOLE   463,886 0 0
Allergan plc Preferred Convertible G0177J116 4,168 5,000 SH   SOLE   5,000 0 0
Alliqua BioMedical, Inc. Common 019621200 1,848 1,650,000 SH   SOLE   1,650,000 0 0
Allscripts Healthcare Solutions, Inc. Common 01988P108 2,205 173,600 SH   SOLE   173,600 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 13,539 243,995 SH   SOLE   243,995 0 0
AmerisourceBergen Corporation Common 03073E105 29,864 376,500 SH   SOLE   376,500 0 0
AmerisourceBergen Corporation Common 03073E105 3,292 41,500 SH Call SOLE   41,500 0 0
Amgen Inc. Common 031162100 50,474 331,740 SH   SOLE   331,740 0 0
Amgen Inc. Common 031162100 1,537 10,100 SH Call SOLE   10,100 0 0
Amicus Therapeutics, Inc. Common 03152W109 1,409 258,000 SH   SOLE   258,000 0 0
ARCA biopharma, Inc. Common 00211Y407 2,353 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 12,129 1,389,370 SH   SOLE   1,389,370 0 0
ARIAD Pharmaceuticals Inc. Common 04033A100 3,710 502,000 SH   SOLE   502,000 0 0
AstraZeneca PLC Sponsored ADR 046353108 3,327 110,200 SH Call SOLE   110,200 0 0
AstraZeneca PLC Sponsored ADR 046353108 17,329 574,000 SH   SOLE   574,000 0 0
Auris Medical Holding AG Common H03579101 3,496 834,263 SH   SOLE   834,263 0 0
BeiGene Ltd. Sponsored ADR 07725L102 3,478 116,707 SH   SOLE   116,707 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 778 60,000 SH   SOLE   60,000 0 0
Biogen Inc. Common 09062X103 108,948 450,533 SH   SOLE   450,533 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 50,869 653,845 SH   SOLE   653,845 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 4,489 57,700 SH Call SOLE   57,700 0 0
bluebird bio, Inc. Common 09609G100 2,136 49,345 SH   SOLE   49,345 0 0
Bristol-Myers Squibb Co. Common ADI0M9WV6 6,421 87,300 SH Put SOLE   87,300 0 0
Care Capital Properties, Inc. Common 141624106 2,210 84,316 SH   SOLE   84,316 0 0
Celgene Corporation Common 151020104 137,963 1,398,789 SH   SOLE   1,398,789 0 0
Celgene Corporation Common 151020104 3,077 31,200 SH Call SOLE   31,200 0 0
Celldex Therapeutics, Inc. Common 15117B103 464 105,800 SH   SOLE   105,800 0 0
Cellectis S.A. Sponsored ADS 15117K103 8,250 310,250 SH   SOLE   310,250 0 0
Centene Corporation Common 15135B101 8,564 120,000 SH   SOLE   120,000 0 0
Cepheid, Inc. Common 15670R107 10,258 333,590 SH   SOLE   333,590 0 0
Cepheid, Inc. Note 1.25% 2/1/21 15670RAC1 8,669 10,000,000 PRN   SOLE   10,000,000 0 0
Chimerix, Inc. Common 16934W106 1,214 308,892 SH   SOLE   308,892 0 0
Cidara Therapeutics, Inc. Common 171757107 1,366 132,472 SH   SOLE   132,472 0 0
Community Health Systems, Inc. Common 203668108 3,669 304,472 SH   SOLE   304,472 0 0
Corsicanto Ltd Note 3.50% 1/15/32 220480AB3 14,930 14,700,000 PRN   SOLE   14,700,000 0 0
CVS Caremark Corporation Common 126650100 21,435 223,891 SH   SOLE   223,891 0 0
Cynapsus Therapeutics, Inc. Common 23257Y859 7,708 460,207 SH   SOLE   460,207 0 0
CytomX Therapeutics, Inc. Common 23284F105 7,723 756,090 SH   SOLE   756,090 0 0
DBV Technologies S.A. Sponsored ADR 23306J101 2,140 65,600 SH   SOLE   65,600 0 0
Depomed Inc. Common 249908104 3,924 200,000 SH   SOLE   200,000 0 0
Dynavax Technologies Corporation Common 268158201 5,031 345,050 SH   SOLE   345,050 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 5,281 7,000,000 PRN   SOLE   7,000,000 0 0
Eli Lilly and Company Common 532457108 39,577 502,567 SH   SOLE   502,567 0 0
Endo International plc Shares G30401106 4,464 286,348 SH   SOLE   286,348 0 0
Endologix Inc. Common 29266S106 6,865 551,000 SH   SOLE   551,000 0 0
Epizyme, Inc. Common 29428V104 4,096 400,000 SH   SOLE   400,000 0 0
Esperion Therapeutics, Inc. Common 29664W105 1,016 102,800 SH   SOLE   102,800 0 0
Exelixis, Inc. Common 30161Q104 10,976 1,405,420 SH   SOLE   1,405,420 0 0
Flamel Technologies SA Sponsored ADR 338488109 6,705 624,288 SH   SOLE   624,288 0 0
Flex Pharm, Inc. Common 33938A105 1,655 162,124 SH   SOLE   162,124 0 0
Foamix Pharmaceuticals Ltd. Shares M46135105 6,135 966,065 SH   SOLE   966,065 0 0
Forward Pharma A/S Sponsored ADR 34986J105 2,481 136,547 SH   SOLE   136,547 0 0
Galapagos NV Sponsored ADR 36315X101 8,195 147,738 SH   SOLE   147,738 0 0
GenMark Diagnostics, Inc. Common 372309104 812 93,349 SH   SOLE   93,349 0 0
Gilead Sciences, Inc. Common 375558103 209,529 2,511,731 SH   SOLE   2,511,731 0 0
Gilead Sciences, Inc. Common 375558103 4,788 57,400 SH Call SOLE   57,400 0 0
GlaxoSmithKline plc Common 37733W105 3,259 75,200 SH Call SOLE   75,200 0 0
GlaxoSmithKline plc Sponsored ADR 37733W105 18,818 434,200 SH   SOLE   434,200 0 0
Global Blood Therapeutics, Inc. Common 37890U108 2,074 125,000 SH   SOLE   125,000 0 0
Grifols SA Sponsored ADR 398438408 2,767 166,000 SH   SOLE   166,000 0 0
Halozyme Therapeutics, Inc. Common 40637H109 1,726 200,000 SH   SOLE   200,000 0 0
HCA Holdings, Inc. Common 40412C101 25,798 334,998 SH   SOLE   334,998 0 0
Heron Therapeutics, Inc. Common 427746102 8,886 492,303 SH   SOLE   492,303 0 0
Horizon Pharma plc Shares G4617B105 12,351 749,900 SH   SOLE   749,900 0 0
Humana Inc. Common 444859102 23,258 129,300 SH   SOLE   129,300 0 0
ICON plc Shares G4705A100 5,041 72,000 SH   SOLE   72,000 0 0
IDEXX Laboratories, Inc. Common 45168D104 12,290 132,352 SH   SOLE   132,352 0 0
Illumina Inc. Common 452327109 52,132 371,364 SH   SOLE   371,364 0 0
Immunomedics, Inc. Note 4.75% 2/15/20 452907AK4 2,715 4,000,000 PRN   SOLE   4,000,000 0 0
Impax Laboratories, Inc. Common 45256B101 3,583 124,335 SH   SOLE   124,335 0 0
Incyte Corporation Common 45337C102 70,419 880,461 SH   SOLE   880,461 0 0
Inotek Pharmaceuticals Corporation Common 45780V102 1,345 180,762 SH   SOLE   180,762 0 0
Intellia Therapeutics, Inc. Common 45826J105 1,854 86,842 SH   SOLE   86,842 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 7,290 187,800 SH   SOLE   187,800 0 0
Ishares Nasdaq Biotechnology ETF ETF 464287556 14,841 57,670 SH   SOLE   57,670 0 0
Jazz Pharmaceuticals plc Shares G50871105 22,108 156,451 SH   SOLE   156,451 0 0
Johnson & Johnson Common 478160104 40,916 337,312 SH   SOLE   337,312 0 0
Juno Therapeutics, Inc. Common 48205A109 6,996 182,000 SH   SOLE   182,000 0 0
Karyopharm Therapeutics, Inc. Common 48576U106 3,357 500,324 SH   SOLE   500,324 0 0
Kite Pharma, Inc. Common 49803L109 2,050 41,000 SH   SOLE   41,000 0 0
LTC Properties Inc. Common 502175102 5,494 106,212 SH   SOLE   106,212 0 0
Mallinckrodt plc Shares G5785G107 13,609 223,900 SH   SOLE   223,900 0 0
McKesson Corporation Common 58155Q103 2,800 15,000 SH   SOLE   15,000 0 0
Medical Properties Trust, Inc. Common 58463J304 13,999 920,393 SH   SOLE   920,393 0 0
The Medicines Company Common 584668105 9,403 279,600 SH Call SOLE   279,600 0 0
The Medicines Company Common 584688105 23,684 704,238 SH   SOLE   704,238 0 0
Medivation, Inc. Common 58501N101 15,475 256,638 SH   SOLE   256,638 0 0
Medivation, Inc. Common 58501N101 3,618 60,000 SH Call SOLE   60,000 0 0
Medtronic plc Shares G5960L103 59,325 683,704 SH   SOLE   683,704 0 0
Merck & Co., Inc. Common 58933Y105 45,950 797,597 SH   SOLE   797,597 0 0
Merrimack Pharmaceuticals, Inc. Note 4.50% 7/15/20 590328AA8 1,654 1,485,000 PRN   SOLE   1,485,000 0 0
Merrimack Pharmaceuticals, Inc. Common 590328100 1,542 286,000 SH   SOLE   286,000 0 0
Merus B.V. Common N5749R100 2,113 260,000 SH   SOLE   260,000 0 0
Molina Healthcare, Inc. Common 60855R100 26,841 537,901 SH   SOLE   537,901 0 0
Momenta Pharmaceuticals, Inc. Common 60877T100 1,660 153,700 SH   SOLE   153,700 0 0
Mylan NV Shares N59465109 31,243 722,552 SH   SOLE   722,552 0 0
Mylan NV Shares N59465109 4,523 104,600 SH Call SOLE   104,600 0 0
Natera, Inc. Common 632307104 10,646 882,358 SH   SOLE   882,358 0 0
Neurocrine Biosciences, Inc. Common 64125C109 34,861 767,022 SH   SOLE   767,022 0 0
Neurocrine Biosciences, Inc. Common 64125C109 5,018 110,400 SH Call SOLE   110,400 0 0
Nevro Corp. Common 64157F103 3,673 49,800 SH   SOLE   49,800 0 0
Novartis AG Sponsored ADR 66987V109 14,035 170,100 SH   SOLE   170,100 0 0
Novavax, Inc. Common 670002104 2,603 358,000 SH   SOLE   358,000 0 0
Omega Healthcare Investors Inc. Common 681936100 14,025 413,116 SH   SOLE   413,116 0 0
Paratek Pharmaceuticals, Inc. Common 699374302 10,608 762,581 SH   SOLE   762,581 0 0
Perrigo Company plc Shares G97822103 3,382 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 52,227 1,483,291 SH   SOLE   1,483,291 0 0
Physicians Realty Trust Common 71943U104 11,149 530,672 SH   SOLE   530,672 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 6,196 3,848,191 SH   SOLE   3,848,191 0 0
PRA Health Sciences, Inc. Common 69354M108 4,260 102,000 SH   SOLE   102,000 0 0
Puma Biotechnology, Inc. Common 74587V107 7,751 260,200 SH   SOLE   260,200 0 0
Quorum Health Corp. Common 74909E106 815 76,118 SH   SOLE   76,118 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 53,874 154,266 SH   SOLE   154,266 0 0
Retrophin, Inc. Common 761299106 5,876 329,949 SH   SOLE   329,949 0 0
Revance Therapeutics, Inc. Common 761330109 1,020 75,000 SH   SOLE   75,000 0 0
The RMR Group Inc., Class A Class A 74967R106 230 7,441 SH   SOLE   7,441 0 0
Sabra Health Care REIT Inc. Common 78573L106 9,413 456,190 SH   SOLE   456,190 0 0
Sage Therapeutics, Inc. Common 78667J108 4,423 146,800 SH   SOLE   146,800 0 0
Sagent Pharmaceuticals, Inc. Common 786692103 4,294 286,650 SH   SOLE   286,650 0 0
Sanofi Sponsored ADR 80105N105 12,764 305,000 SH   SOLE   305,000 0 0
Senior Housing Properties Trust Shares 81721M109 13,967 670,504 SH   SOLE   670,504 0 0
Shire plc Sponsored ADR 82481R106 37,131 201,713 SH   SOLE   201,713 0 0
SPDR S&P Biotech ETF S&P Biotech 78464A870 15,902 294,000 SH   SOLE   294,000 0 0
St. Jude Medical, Inc. Common 790849103 12,387 158,805 SH   SOLE   158,805 0 0
Supernus Pharmaceuticals, Inc. Note 7.50% 5/1/19 868459AB4 7,688 2,000,000 PRN   SOLE   2,000,000 0 0
Tenet Healthcare Corporation Common 88033G407 4,547 164,500 SH   SOLE   164,500 0 0
Tetraphase Pharmaceuticals Inc. Common 88165N105 827 192,322 SH   SOLE   192,322 0 0
Teva Pharmaceutical Industries Ltd. ADR 881624209 33,752 671,958 SH   SOLE   671,958 0 0
Thermo Fisher Scientific Inc. Common 883556102 12,766 86,395 SH   SOLE   86,395 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 4,324 88,400 SH   SOLE   88,400 0 0
UniQure NV Shares N90064101 1,776 241,021 SH   SOLE   241,021 0 0
United Therapeutics Corporation Common 91307C102 9,861 93,100 SH   SOLE   93,100 0 0
UnitedHealth Group, Inc. Common 91324P102 46,751 331,100 SH   SOLE   331,100 0 0
Universal Health Services, Inc. Class B 913903100 18,061 134,680 SH   SOLE   134,680 0 0
Valeant Pharmaceuticals International, Inc. Common 91911K102 3,867 192,000 SH   SOLE   192,000 0 0
Ventas, Inc. Common 92276F100 11,104 152,491 SH   SOLE   152,491 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 88,902 1,033,503 SH   SOLE   1,033,503 0 0
Welltower, Inc. Preferred Convertible 95040Q203 13,560 200,000 SH   SOLE   200,000 0 0
Wright Medical Group NV Ordinary Shares N96617118 6,999 402,950 SH   SOLE   402,950 0 0
Wright Medical Group NV Ordinary Shares N96617118 2,936 169,000 SH Call SOLE   169,000 0 0
Xencor, Inc. Common 98401F105 380 20,000 SH   SOLE   20,000 0 0
Zafgen, Inc. Common 98885E103 80 13,307 SH   SOLE   13,307 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 12,315 102,300 SH   SOLE   102,300 0 0