The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 3,398 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
AEGERION PHARMACEUTICALS INC COM 00767E102 1,490 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
AGENUS INC COM NEW 00847G705 4,050 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
AGENUS INC COM NEW 00847G705 2,025 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 15,711 375,000 SH   DFND 1,2,3,4,5 375,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 31,812 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 39,398 710,000 SH   DFND 1,2,3,4,5 710,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 16,647 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
ALPHABET INC CAP STK CL A 02079K305 28,141 40,000 SH Call DFND 1,2,3,4,5 40,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 6,825 1,250,000 SH   DFND 1,2,3,4,5 1,250,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 13,777 3,870,000 SH   DFND 1,2,3,4,5 3,870,000 0 0
AVEXIS INC COM 05366U100 6,155 161,900 SH   DFND 1,2,3,4,5 161,900 0 0
BANK AMER CORP COM 060505104 14,597 1,100,000 SH   DFND 1,2,3,4,5 1,100,000 0 0
BANK AMER CORP COM 060505104 66,350 5,000,000 SH Call DFND 1,2,3,4,5 5,000,000 0 0
BIOGEN INC COM 09062X103 36,273 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 27,230 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
BIOTIME INC COM 09066L105 3,346 1,282,050 SH   DFND 1,2,3,4,5 1,282,050 0 0
BLUEBIRD BIO INC COM 09609G100 19,481 450,000 SH   DFND 1,2,3,4,5 450,000 0 0
BLUEBIRD BIO INC COM 09609G100 4,329 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 2,683,809 114,987,547 SH   DFND 1,2,3,4 114,987,547 0 0
CELGENE CORP COM 151020104 19,726 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 2,963 675,000 SH   DFND 1,2,3,4,5 675,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 5,584 210,000 SH   DFND 1,2,3,4,5 210,000 0 0
CEMPRA INC COM 15130J109 1,649 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CERES INC COM NEW 156773400 400 1,024,020 SH   DFND 1,2,3,4 1,024,020 0 0
CHEMOCENTRYX INC COM 16383L106 4,041 900,000 SH   DFND 1,2,3,4,5 900,000 0 0
CITIGROUP INC COM NEW 172967424 10,598 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 46 5,575 SH   DFND 1,2,3,4 5,575 0 0
DELPHI AUTOMOTIVE PLC SHS G27823106 17,215 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 1,650 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 2,074 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 29,716 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 185,725 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
HORIZON PHARMA PLC SHS G4617B105 5,765 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
IGNYTA INC COM 451731103 4,065 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
INCYTE CORP COM 45337C102 49,988 625,000 SH   DFND 1,2,3,4,5 625,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 4,804 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 15,178 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,836 216,879 SH   DFND 1,2,3,4 216,879 0 0
JD COM INC SPON ADR CL A 47215P106 5,308 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
JPMORGAN CHASE & CO COM 46625H100 15,535 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 7,688 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 1,922 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
KITE PHARMA INC COM 49803L109 16,250 325,000 SH   DFND 1,2,3,4,5 325,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 11,384 793,327 SH   DFND 1,2,3,4,5 793,327 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 813,999 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
METLIFE INC COM 59156R108 9,958 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
METLIFE INC COM 59156R108 19,915 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
MORGAN STANLEY COM NEW 617446448 10,392 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
NANTKWEST INC COM 63016Q102 1,400 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
NEKTAR THERAPEUTICS COM 640268108 19,922 1,400,000 SH   DFND 1,2,3,4,5 1,400,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,318 95,000 SH   DFND 1,2,3,4,5 95,000 0 0
ONCOCYTE CORPORATION COM 68235C107 228 64,102 SH   DFND 1,2,3,4,5 64,102 0 0
OPHTHOTECH CORP COM 683745103 2,552 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
RADIUS HEALTH INC COM NEW 750469207 3,675 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
RADIUS HEALTH INC COM NEW 750469207 3,675 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 17,462 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 41,908 120,000 SH Call DFND 1,2,3,4,5 120,000 0 0
REGENXBIO INC COM 75901B107 1,600 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 3,013 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,907 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
SERES THERAPEUTICS INC COM 81750R102 9,006 310,000 SH   DFND 1,2,3,4,5 310,000 0 0
SPARK THERAPEUTICS INC COM 84652J103 2,557 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
SPECTRANETICS CORP COM 84760C107 6,549 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
TESLA MTRS INC COM 88160R101 15,921 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,668 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
US FOODS HLDG CORP COM 912008109 12,120 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,903 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
WAL-MART STORES INC COM 931142103 36,510 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 342,426 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0