The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 80,333 9,880,999 SH   DFND 0 9,880,999 0 0
AEROHIVE NETWORKS INC COM 007786106 23,360 4,681,455 SH   DFND 0 4,681,455 0 0
AGILE THERAPEUTICS INC COM 00847L100 829 133,488 SH   DFND 0 133,488 0 0
AKARI THERAPEUTICS PLC ADR 009726108 6,143 438,780 SH   DFND 0 438,780 0 0
ARCA BIOPHARMA INC COM PAR $.001 00211Y407 5,067 1,460,209 SH   DFND 0 1,460,209 0 0
ARDELYX INC COM 039697107 91,629 11,792,631 SH   DFND 0 11,792,631 0 0
ARQULE INC COM 04269E107 4,033 2,520,316 SH   DFND 0 2,520,316 0 0
AURINA PHARMACEUTICALS INC COM 05156V102 7,411 2,546,843 SH   DFND 0 2,546,843 0 0
CARE COM INC COM 141633107 20,055 3,260,989 SH   DFND 0 3,260,989 0 0
CATALYST BIOSCIENCES INC COM 14888D109 1,096 652,380 SH   DFND 0 652,380 0 0
CERECOR INC COM 15671L109 2,221 595,435 SH   DFND 0 595,435 0 0
CHAMPIONS ONCOLOGY INC COM 15870P307 5,688 1,562,500 SH   DFND 0 1,562,500 0 0
CLOVIS ONCOLOGY INC COM 189464100 21,886 1,139,890 SH   DFND 0 1,139,890 0 0
DERMIRA INC COM 24983L104 72,518 3,506,649 SH   DFND 0 3,506,649 0 0
ENDOLOGIX INC COM 29266S106 20,818 2,490,204 SH   DFND 0 2,490,204 0 0
EPIZYME INC COM 29428V104 75,882 6,260,851 SH   DFND 0 6,260,851 0 0
EXELIXIS INC COM 30161Q104 8,828 2,207,000 SH   DFND 0 2,207,000 0 0
GLYCOMIMETICS INC COM 38000Q102 51,161 8,584,128 SH   DFND 0 8,584,128 0 0
GROUPON INC COM CL A 399473107 176,250 44,172,953 SH   DFND 0 44,172,953 0 0
LEXICON PHARMACEUTICALS INC COM 528872302 28,468 2,382,286 SH   DFND 0 2,382,286 0 0
LOXO ONCOLOGY INC COM 548862101 48,999 1,792,207 SH   DFND 0 1,792,207 0 0
MIRNA THERAPEUTICS INC COM 60470J103 13,000 2,974,811 SH   DFND 0 2,974,811 0 0
NEVRO CORP COM 64157F103 37,156 660,428 SH   DFND 0 660,428 0 0
OPOWER INC COM 68375Y109 61,272 8,997,290 SH   DFND 0 8,997,290 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 2,077 3,709,000 SH   DFND 0 3,709,000 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,896 125,004 SH   DFND 0 125,004 0 0
RIGEL PHARMACEUTICALS INC COM 766559603 6,746 3,243,150 SH   DFND 0 3,243,150 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 29,838 3,095,240 SH   DFND 0 3,095,240 0 0
ROKA BIOSCIENCE INC COM 775431109 2,222 3,220,433 SH   DFND 0 3,220,433 0 0
SENSEONICS HOLDINGS INC COM 81727U105 75,227 26,303,189 SH   DFND 0 26,303,189 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 9,764 2,141,308 SH   DFND 0 2,141,308 0 0
SUNESIS PHARMACEUTICALS INC COM 867328601 4,206 7,789,644 SH   DFND 0 7,789,644 0 0
TESARO INC COM 881569107 452,413 10,275,113 SH   DFND 0 10,275,113 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 13,209 1,889,652 SH   DFND 0 1,889,652 0 0
TREVENA INC COM 89532E109 31,523 3,811,691 SH   DFND 0 3,811,691 0 0
ZHONE TECHNOLOGIES INC COM 98950P884 7,650 4,781,290 SH   DFND 0 4,781,290 0 0
ZOSANO PHARMA CORP COM 98979H103 4,965 2,158,543 SH   DFND 0 2,158,543 0 0