0000909012-12-000373.txt : 20120815 0000909012-12-000373.hdr.sgml : 20120815 20120815170133 ACCESSION NUMBER: 0000909012-12-000373 CONFORMED SUBMISSION TYPE: 13F-HR/A PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20120630 FILED AS OF DATE: 20120815 DATE AS OF CHANGE: 20120815 EFFECTIVENESS DATE: 20120815 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PERCEPTIVE ADVISORS LLC CENTRAL INDEX KEY: 0001224962 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR/A SEC ACT: 1934 Act SEC FILE NUMBER: 028-10438 FILM NUMBER: 121037710 BUSINESS ADDRESS: STREET 1: 499 PARK AVENUE, 25TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: 646-205-5340 MAIL ADDRESS: STREET 1: 499 PARK AVENUE, 25TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR/A 1 t306878.txt PERCEP 13F-A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F-HR Form 13F COVER PAGE Report for the Calendar Year of Quarter Ended: June 30, 2012 Check here if Amendment [X]; Amendment Number: 1 This Amendment (Check only one.): [X] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: Perceptive Advisors LLC Address: 499 Park Ave, 25th Floor New York, NY 10022 Form 13F File Number: 28-10438 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Joseph Edelman Title: Managing Member Phone: (646) 205-5342 Signature, Place, and Date of Signing: /s/ Joseph Edelman New York, NY August 15, 2012 [Signature] [City, State] [Date] Report Type (Check only one.): [ X ] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) [ ] 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) [ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).) Form 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 70 Form 13F Information Table Value Total: $404,210 (thousands) List of Other Included Managers: {None}

Title of Value Shs or Sh/ Put/ Investment Other Voting Authority Name of Issuer Class CUSIP (x1000) Prn Amt Prn Call Discretion Managers Sole Shared None JAZZ PHARMACEUTICALS PLC SHS USD G50871105 225 5,000 SH 5,000 WARNER CHILCOTT PLC IRELAND SHS A G94368100 1,345 75,000 SH 75,000 SYNERON MEDICAL LTD ORD SHS M87245102 1,758 169,400 SH 169,400 AVI BIOPHARMA INC COM 2346104 1,816 2,901,209 SH 2,901,209 AEGERION PHARMACEUTICALS INC COM 7.67E+104 24,533 1,653,181 SH 1,653,181 AFFYMAX INC COM 00826A109 2,318 180,000 SH 180,000 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 2,761 237,017 SH 237,017 AMGEN INC COM 31162100 3,646 50,000 SH 50,000 ANGEION CORP COM 03462H404 584 102,306 SH 102,306 ANTHERA PHARMACEUTICALS INC COM 03674U102 41 60,000 SH 60,000 ARENA PHARMACEUTICALS INC COM 40047102 1,995 200,000 Call 200,000 ARENA PHARMACEUTICALS INC COM 40047102 7,980 80,000 Put 80,000 ARENA PHARMACEUTICALS INC COM 40047102 6,334 635,000 SH 635,000 ARIAD PHARMACEUTICALS INC COM 04033A100 13,684 795,100 SH 795,100 ARRAY BIOPHARMA INC COM 04269X105 347 100,000 SH 100,000 ATHERSYS INC COM 04744L106 2,345 1,456,797 SH 1,456,797 BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,979 50,000 SH 50,000 BIOGEN IDEC INC COM 09062X103 1,444 10,000 SH 10,000 BIOMIMETIC THERAPEUTICS INC COM 09064X101 263 100,000 SH 100,000 CAPITAL SR LIVING CORP COM 140475104 16,685 1,574,041 SH 1,574,041 CELGENE CORP COM 151020104 5,774 90,000 SH 90,000 CELSION CORPORATION COM NEW 15117N305 192 62,600 SH 62,600 CHEMOCENTRYX INC COM 16383L106 309 20,600 SH 20,600 CLOVIS ONCOLOGY INC COM 189464100 2,729 125,881 SH 125,881 COMBIMATRIX CORPORATION *W EXP 05/01/201 20009T113 5 50,000 SH 50,000 CONCEPTUS INC COM 206016107 4,231 213,454 SH 213,454 CUTERA INC COM 232109108 2,430 337,775 SH 337,775 JAZZ PHARMACEUTICALS PLC SHS USD 249908104 3,699 650,000 SH 650,000 DYAX CORP COM 2.67E+107 1,970 924,957 SH 924,957 ENDO HEALTH SOLUTIONS INC COM 29264F205 10,616 342,672 SH 342,672 EXACT SCIENCES CORP COM 30063P105 2,144 200,000 SH 200,000 GENVEC INC COM NEW 37246C307 33 13,964 SH 13,964 IDENIX PHARMACEUTICALS INC COM 45166R204 514 50,000 Put 50,000 ILLUMINA INC COM 452327109 11,915 295,000 SH 295,000 IMMUNOMEDICS INC COM 452907108 651 182,856 SH 182,856 INFINITY PHARMACEUTICALS INC COM 45665G303 29,021 2,140,168 SH 2,140,168 LEXICON PHARMACEUTICALS INC COM 528872104 893 397,700 SH 397,700 LIGAND PHARMACEUTICALS INC COM NEW 53220K504 783 46,225 SH 46,225 MAKO SURGICAL CORP COM 560879108 2,561 100,000 Call 100,000 MEDICIS PHARMACEUTICAL CORP CL A NEW 584690309 6,813 199,500 Call 199,500 MEDIVATION INC COM 58501N101 16,099 176,143 SH 176,143 MYLAN INC COM 628530107 15,600 730,000 SH 730,000 NPS PHARMACEUTICALS INC COM 62936P103 8,837 1,026,400 SH 1,026,400 NEOSTEM INC COM NEW 640650305 1,614 3,292,838 SH 3,292,838 NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 13,735 2,897,690 SH 2,897,690 NEUROCRINE BIOSCIENCES INC COM 64125C109 29,243 3,704,037 SH 3,704,037 ONYX PHARMACEUTICALS INC COM 683399109 6,645 100,000 Put 100,000 ONYX PHARMACEUTICALS INC COM 683399109 3,987 60,000 SH 60,000 OPTIMER PHARMACEUTICALS INC COM 68401H104 1,546 100,000 Call 100,000 PHARMACYCLICS INC COM 716933106 1,092 20,000 SH 20,000 PROLOR BIOTECH INC COM 74344F106 4,859 970,000 SH 970,000 PROTALIX BIOTHERAPEUTICS INC COM 74365A101 3,274 571,449 SH 571,449 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 2,662 50,000 Put 50,000 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 26,620 500,000 SH 500,000 RAPTOR PHARMACEUTICAL CORP COM 75382F106 349 62,500 SH 62,500 REGENERON PHARMACEUTICALS COM 75886F107 28,555 250,000 Call 250,000 REPROS THERAPEUTICS INC COM NEW 76028H209 25,992 2,862,560 SH 2,862,560 SAGENT PHARMACEUTICALS INC COM 786692103 685 37,899 SH 37,899 SEATTLE GENETICS INC COM 812578102 5,078 200,000 Call 200,000 SENESCO TECHNOLOGIES INC COM NEW 817208408 139 669,642 SH 669,642 SUNRISE SENIOR LIVING INC COM 86768K106 3,666 502,900 SH 502,900 SYNTA PHARMACEUTICALS CORP COM 87162T206 4,057 741,636 SH 741,636 SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 1,188 250,000 SH 250,000 TRANSGENOMIC INC COM 89365K206 2,222 2,000,000 SH 1,900,000 TRINITY BIOTECH PLC SPON ADR NEW 896438306 444 36,960 SH 36,960 TRIUS THERAPEUTICS INC COM 89685K100 1 175 SH 175 UNITED THERAPEUTICS CORP DEL COM 91307C102 8,395 170,000 SH 170,000 UROPLASTY INC COM NEW 917277204 2,191 477,300 SH 477,300 VALEANT PHARMACEUTICALS INTL COM 91911K102 4,489 100,000 Call 100,000 XOMA CORP DEL COM 98419J107 1,580 530,303 SH 530,303 404,210