0001172661-11-000387.txt : 20110516 0001172661-11-000387.hdr.sgml : 20110516 20110516144510 ACCESSION NUMBER: 0001172661-11-000387 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20110331 FILED AS OF DATE: 20110516 DATE AS OF CHANGE: 20110516 EFFECTIVENESS DATE: 20110516 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 11845812 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb1q11.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2011 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY May 16, 2011 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 118 Form13F Information Table Value Total: $2,965,719 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 OrbiMed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- 3SBIO INC SPONSORED ADR 88575Y105 22007 1272800 SH DEFINED 1 1229300 0 43500 ABBOTT LABS COM 002824100 18173 370500 SH SOLE 237000 0 133500 ACHILLION PHARMACEUTICALS IN COM 00448Q201 2839 397100 SH DEFINED 1 266600 0 130500 AETNA INC NEW COM 00817Y108 23903 638600 SH DEFINED 1 504600 0 134000 AFFYMETRIX INC NOTE 3.500% 1/1 00826TAG3 13677 2625200 PRN DEFINED 1 2143800 0 481400 AGILENT TECHNOLOGIES INC COM 00846U101 5598 125000 SH SOLE 0 0 125000 ALEXION PHARMACEUTICALS INC COM 015351109 6019 61000 SH DEFINED 1 61000 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 9896 100000 SH CALL DEFINED 1 100000 0 0 ALIGN TECHNOLOGY INC COM 016255101 20769 1014100 SH DEFINED 1 1014100 0 0 ALLERGAN INC COM 018490102 111175 1565400 SH DEFINED 1 1252400 0 313000 ALLOS THERAPEUTICS INC COM 019777101 30265 9577600 SH DEFINED 1 8176600 0 1401000 AMARIN CORP PLC SPONS ADR NEW 023111206 47450 6500000 SH SOLE 6500000 0 0 AMGEN INC COM 031162100 19547 365700 SH DEFINED 1 160700 0 205000 AMYLIN PHARMACEUTICALS INC COM 032346108 2843 250000 SH PUT DEFINED 1 250000 0 0 ANADYS PHARMACEUTICALS INC COM 03252Q408 6229 5369900 SH DEFINED 1 4519900 0 850000 ANTARES PHARMA INC COM 036642106 11594 6441100 SH DEFINED 1 3952800 0 2488300 ANTHERA PHARMACEUTICALS INC COM 03674U102 23286 3449734 SH SOLE 3449734 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 3374 448700 SH DEFINED 1 448700 0 0 ARQULE INC COM 04269E107 13277 1859500 SH DEFINED 1 1689500 0 170000 ATHERSYS INC COM 04744L106 5126 1805100 SH SOLE 1805100 0 0 AVEO PHARMACEUTICALS INC COM 053588109 5400 405400 SH DEFINED 1 297800 0 107600 BAXTER INTL INC COM 071813109 60023 1116300 SH DEFINED 1 751300 0 365000 BIOGEN IDEC INC COM 09062X103 13210 179800 SH DEFINED 1 99800 0 80000 BIOMARIN PHARMACEUTICAL INC COM 09061G101 67600 2690000 SH DEFINED 1 2361000 0 329000 BOSTON SCIENTIFIC CORP COM 101137107 8628 1200000 SH SOLE 0 0 1200000 BOSTON SCIENTIFIC CORP COM 101137107 3595 500000 SH PUT SOLE 500000 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 19823 750000 SH CALL DEFINED 1 750000 0 0 BRISTOL MYERS SQUIBB CO COM 110122108 136067 5148200 SH DEFINED 1 4123200 0 1025000 CARDINAL HEALTH INC COM 14149Y108 17780 432300 SH DEFINED 1 297300 0 135000 CAREFUSION CORP COM 14170T101 8883 315000 SH SOLE 215000 0 100000 CELGENE CORP COM 151020104 28237 490400 SH DEFINED 1 395400 0 95000 CEPHALON INC COM 156708109 2305 30300 SH DEFINED 1 30300 0 0 CIGNA CORP COM 125509109 43815 989500 SH DEFINED 1 654500 0 335000 COMPLETE GENOMICS INC COM 20454K104 64176 4156270 SH SOLE 4156270 0 0 COVANCE INC COM 222816100 2627 48000 SH SOLE 0 0 48000 COVIDIEN PLC SHS G2554F105 6752 130000 SH SOLE 0 0 130000 CUBIST PHARMACEUTICALS INC NOTE 2.500%11/0 229678AD9 7647 3173700 PRN SOLE 1173700 0 2000000 CUBIST PHARMACEUTICALS INC COM 229678107 4384 173700 SH DEFINED 1 173700 0 0 CUBIST PHARMACEUTICALS INC COM 229678107 2524 100000 SH CALL DEFINED 1 100000 0 0 CYNOSURE INC CL A 232577205 2499 179900 SH DEFINED 1 139600 0 40300 CYTOKINETICS INC COM 23282W100 1636 1098100 SH DEFINED 1 1098100 0 0 DAVITA INC COM 23918K108 5558 65000 SH SOLE 0 0 65000 DENDREON CORP NOTE 4.750% 6/1 24823QAB3 1000 1000000 PRN SOLE 1000000 0 0 DENDREON CORP COM 24823Q107 50568 1351000 SH DEFINED 1 1142900 0 208100 EDWARDS LIFESCIENCES CORP COM 28176E108 2132 24500 SH PUT DEFINED 1 24500 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 2132 24500 SH CALL DEFINED 1 24500 0 0 EXACT SCIENCES CORP COM 30063P105 10582 1441700 SH SOLE 1222500 0 219200 EXPRESS SCRIPTS INC COM 302182100 66771 1200700 SH SOLE 900700 0 300000 FLUIDIGM CORP DEL COM 34385P108 4624 323100 SH DEFINED 1 213100 0 110000 FOREST LABS INC COM 345838106 5749 178000 SH SOLE 0 0 178000 FOREST LABS INC COM 345838106 6460 200000 SH CALL DEFINED 1 200000 0 0 GENZYME CORP COM 372917104 26070 342300 SH DEFINED 1 342300 0 0 GENZYME CORP COM 372917104 133925 2500000 SH CALL DEFINED 1 2500000 0 0 GILEAD SCIENCES INC COM 375558103 134044 3156200 SH DEFINED 1 2586200 0 570000 GIVEN IMAGING ORD SHS M52020100 27436 1392000 SH DEFINED 1 1149000 0 243000 HCA HOLDINGS INC COM 40412C101 6774 200000 SH DEFINED 1 152400 0 47600 HOLOGIC INC COM 436440101 5550 250000 SH SOLE 0 0 250000 HOSPIRA INC COM 441060100 5520 100000 SH CALL DEFINED 1 100000 0 0 HOSPIRA INC COM 441060100 60913 1103500 SH DEFINED 1 913500 0 190000 HUMAN GENOME SCIENCES INC COM 444903108 58076 2115700 SH DEFINED 1 1778800 0 336900 HUMANA INC COM 444859102 46951 671300 SH DEFINED 1 492300 0 179000 IDENIX PHARMACEUTICALS INC COM 45166R204 958 288700 SH DEFINED 1 182200 0 106500 ILLUMINA INC COM 452327109 59763 852900 SH DEFINED 1 730900 0 122000 INCYTE CORP COM 45337C102 46369 2925500 SH DEFINED 1 2375500 0 550000 INCYTE CORP NOTE 4.750%10/0 45337CAJ1 7720 7720000 PRN DEFINED 1 7720000 0 0 INHIBITEX INC COM 45719T103 8960 2475000 SH SOLE 2475000 0 0 INSULET CORP COM 45784P101 30081 1458803 SH SOLE 1458803 0 0 INTERMUNE INC COM 45884X103 3492 74000 SH DEFINED 1 74000 0 0 INTERMUNE INC COM 45884X103 7079 150000 SH PUT DEFINED 1 150000 0 0 JOHNSON & JOHNSON COM 478160104 34424 581000 SH SOLE 425000 0 156000 K V PHARMACEUTICAL CO CL A 482740206 21030 3510900 SH DEFINED 1 2765400 0 745500 K V PHARMACEUTICAL CO CL A 482740206 1498 250000 SH CALL DEFINED 1 250000 0 0 LIFE TECHNOLOGIES CORP COM 53217V109 39955 762200 SH SOLE 547200 0 215000 LIGAND PHARMACEUTICALS INC COM NEW 53220K504 13 12833 PRN SOLE 12833 0 0 MAP PHARMACEUTICALS INC COM 56509R108 20941 1518600 SH DEFINED 1 1008600 0 510000 MCKESSON CORP COM 58155Q103 24284 307200 SH SOLE 157200 0 150000 MEDCO HEALTH SOLUTIONS INC COM 58405U102 4100 73000 SH DEFINED 1 0 0 73000 MEDIVATION INC COM 58501N101 1398 75000 SH CALL DEFINED 1 75000 0 0 MEDTRONIC INC COM 585055106 45434 1154600 SH SOLE 594600 0 560000 MERCK & CO INC NEW COM 58933Y105 82690 2505000 SH DEFINED 1 1562000 0 943000 NPS PHARMACEUTICALS INC COM 62936P103 37415 3905500 SH DEFINED 1 3580500 0 325000 NXSTAGE MEDICAL INC COM 67072V103 59137 2690476 SH SOLE 2690476 0 0 ONYX PHARMACEUTICALS INC COM 683399109 2821 80200 SH DEFINED 1 80200 0 0 ORASURE TECHNOLOGIES INC COM 68554V108 13794 1755000 SH DEFINED 1 1129700 0 625300 OREXIGEN THERAPEUTICS INC COM 686164104 284 100000 SH DEFINED 1 100000 0 0 OREXIGEN THERAPEUTICS INC COM 686164104 284 100000 SH CALL DEFINED 1 100000 0 0 OREXIGEN THERAPEUTICS INC COM 686164104 284 100000 SH PUT DEFINED 1 100000 0 0 PACIFIC BIOSCIENCES CALIF IN COM 69404D108 2248 160000 SH SOLE 160000 0 0 PACIRA PHARMACEUTICALS INC COM 695127100 20085 2828942 SH SOLE 2828942 0 0 PERRIGO CO COM 714290103 30480 383300 SH DEFINED 1 383300 0 0 PERRIGO CO COM 714290103 7952 100000 SH CALL DEFINED 1 100000 0 0 PFIZER INC COM 717081103 125983 6203000 SH DEFINED 1 4453000 0 1750000 PHARMACYCLICS INC COM 716933106 31246 5305000 SH DEFINED 1 4055000 0 1250000 PHARMACYCLICS INC CALL 716933906 1473 250000 SH CALL DEFINED 1 250000 0 0 PHARMASSET INC COM 71715N106 34506 438400 SH DEFINED 1 286400 0 152000 PHARMASSET INC CALL 71715N906 7871 100000 SH CALL DEFINED 1 100000 0 0 QUEST DIAGNOSTICS INC COM 74834L100 5772 100000 SH SOLE 0 0 100000 REGENERON PHARMACEUTICALS COM 75886F107 3460 77000 SH DEFINED 1 77000 0 0 SEQUENOM INC COM NEW 817337405 2536 400000 SH DEFINED 1 400000 0 0 SEQUENOM INC CALL 817337905 3804 600000 SH CALL DEFINED 1 600000 0 0 SHIRE PLC SPONSORED ADR 82481R106 105367 1210700 SH DEFINED 1 1100700 0 110000 SOLTA MED INC COM 83438K103 1627 492900 SH DEFINED 1 320000 0 172900 STRYKER CORP COM 863667101 22916 376900 SH DEFINED 1 244500 0 132400 SYNERON MEDICAL LTD ORD SHS M87245102 4752 364400 SH DEFINED 1 225400 0 139000 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 7229 144100 SH DEFINED 1 144100 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 59972 1079600 SH DEFINED 1 889600 0 190000 UNITED THERAPEUTICS CORP DEL COM 91307C102 5938 88600 SH DEFINED 1 88600 0 0 UNITEDHEALTH GROUP INC COM 91324P102 63235 1399000 SH DEFINED 1 959000 0 440000 UROPLASTY INC COM NEW 917277204 2509 379600 SH DEFINED 1 379600 0 0 VALEANT PHARMACEUTICALS INTL COM 91911K102 6874 138000 SH SOLE 0 0 138000 VOLCANO CORPORATION COM 928645100 8919 348400 SH DEFINED 1 348400 0 0 VOLCANO CORPORATION NOTE 2.875% 9/0 928645AA8 1500 1500000 PRN SOLE 1500000 0 0 WARNER CHILCOTT PLC IRELAND SHS A G94368100 72036 3097000 SH DEFINED 1 2697000 0 400000 WATSON PHARMACEUTICALS INC COM 942683103 50835 907600 SH DEFINED 1 757600 0 150000 WATSON PHARMACEUTICALS INC CALL 942683903 140 250000 SH CALL DEFINED 1 250000 0 0 WELLPOINT INC COM 94973V107 127199 1822600 SH DEFINED 1 1389100 0 433500 YM BIOSCIENCES INC COM 984238105 1145 433900 SH DEFINED 1 287400 0 146500 ZIMMER HLDGS INC COM 98956P102 26409 436300 SH DEFINED 1 334800 0 101500